Observational Study on Adult Onset Sporadic Ataxias

The clinical picture of sporadic degenerative ataxias is divided into cerebellar-type multiple system atrophy (MSA) and "sporadic adult onset ataxia of unknown aetiology" (SAOA). The aims of the SPORTAX study are to precisely characterize the two forms of the disease and to compare their courses. In addition, it will seek to identify factors that can influence the development of the disease and that can be used to precisely diagnose it, at early stages.

Further information is available  here.

Principle Investigator: Prof. Dr. Thomas Klockgether
Start of the study: 2010
Status: multi centric, ongoing, recruiting active

Study coordination / Project management

Demet Önder
Dr. Jennifer Faber (Vertretung)


Faber J, Giordano I, Jiang X, Kindler C, Spottke A, Acosta-Cabronero J, Nestor PJ, Machts J, Düzel E, Vielhaber S, Speck O, Dudesek A, Kamm C, Scheef L, Klockgether T. Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type. Mov Disord. 2020 May 15; 35 (5); 816-824. doi: 10.1002/mds.27987.

Giordano I, Harmuth F, Jacobi H, Paap B, Vielhaber S, Machts J, Schöls L, Synofzik M, Sturm M, Tallaksen C, Wedding IM, Boesch S, Eigentler A, van de Warrenburg B, van Gaalen J, Kamm C, Dudesek A, Kang JS, Timmann D, Silvestri G, Masciullo M, Klopstock T, Neuhofer C, Ganos C, Filla A, Bauer P, Tezenas du Montcel S, Klockgether T. Clinical and genetic characteristics of sporadic adult-onset degenerative ataxia. Neurology. 2017 Sep 05; 89(10). doi: 10.1212/WNL.0000000000004311.

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