Alpha-FIT

Isolated REM sleep behavior disorder is considered a possible early sign of Parkinson's disease and is associated with an increased risk of developing this disease. Since there is currently no proven preventive treatment, studies suggest that an active lifestyle—especially regular physical exercise—can reduce the risk of Parkinson's disease and cognitive decline.

With this in mind, research is being conducted to investigate how increasing everyday physical activity affects physical and mental health.

The aim of the study is to examine whether a smartphone-based exercise intervention has positive effects on cognitive performance in people with isolated REM sleep behavior disorder. The success of the intervention will be assessed based on changes in physical activity and mental functions (e.g., memory and attention). In addition, further clinical data, blood markers, and brain imaging techniques will be evaluated.

During a four-week eligibility phase, movement parameters are recorded using the Fitbit smartwatch and app to check suitability for the study.
This is followed by three study appointments over a period of approximately one year, during which cognitive and motor tests, clinical examinations including blood samples, MRI-based brain imaging, and a sleep study in the home environment are carried out.

In addition, participants' cognitive abilities will be digitally recorded every two weeks using the NeuroNation app on their smartphones.

You can download all further information and details on participation here (in German only): Flyer Alpha-FIT

We are looking for participants aged between 50 and 80 with a confirmed clinical diagnosis of isolated REM sleep behavior disorder who are willing to use a digital exercise program via an app and a free Fitbit smartwatch for a period of around one year. There will be three accompanying clinic appointments.

If you would like to participate in this study, please contact RBDStudie(at)ukbonn.de.

Start of the study: December 2025
Status: monocentric (DZNE + University Hospital Bonn), recuitment active

Principal Investigator: 
PD Dr. Michael Sommerauer
Universitätsklinikum Bonn - Klinik für Parkinson, Schlaf- und Bewegungsstörungen
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.

Study coordination / Project management:
Martin Rodemann, Emily Fitzgibbon, Claudia Koopmann