Translational Health Care Research
Prof. Dr. Wolfgang Hoffmann
Group Leader and Site Speaker
c/o Ellernholzst. 1-2
Institut für Community Medicine
Versorgnungsepidemiologie und Community Health
Universitätsmedizin Greifswald
17489 Greifswald
 +49 3834 86-7751

Areas of investigation/research focus

Dementia is one of the leading causes of disability among older people. There are currently 1.8 million people affected by dementia. This prevalence is estimated to double every 20 years. Worldwide healthcare cost valued one trillion US-dollar.

The needs of persons with dementia (PwD) and their caregivers are chronic, multimodal, and cumulative and thus, require support from both health and social care. Population-based dementia care research needs to address clinical and primary care, nursing care, social, economic and health system questions. Translational health care research include analyses of health care, development and maintenance of evidence-based qualifications for health professionals, development of complex modular interventions for optimizing dementia treatment and care, and the evaluation of the safety, efficacy and cost-effectiveness of innovative interventions in various settings as well as the translation of effective concepts or evidence in routine care.

The group´s main achievements and goals are (1) to establish a platform for interventional research in primary care, (2) integrate transdisciplinary topics in research, like health economy and research ethics, (3) to translate scientific results into routine care and (4) exchange with health policy and stakeholders.

 more Infos

Primary care is the health care setting where most of the people with dementia are diagnosed and treated. To achieve a high impact on the health care system, research is needed that addresses real world problems and that benefit the primary health care system. Furthermore, low-threshold access is needed to PwD and their caregivers to conduct relevant research and translate research findings from basic and clinical research into routine care and back. Therefore, we have established a primary care research platform, that will allow translational research close to routine care and that will be of significant value for further and future primary care research.

Health care research is trans- and interdisciplinary in its research questions and methodological approaches. Single disciplines like health economy, pharmacy, and ethics are important areas at the DZNE Rostock/Greifswald and various sites at DZNE can benefit from this. There is a need to increase the importance and visibility of transdisciplinary topics and challenges to integrate the DZNE more into the international health care research.

Translational research has become a priority over the last decades, including an effective translation of new knowledge generated by advances in science into practice. This translation from science to practice is important to improve patients’ health. Patients for whom a study intervention is intended need to be involved in the conceptualization, planning and all other stages of research process. Transparent communication with health policy and stakeholders in the health care system support that new approaches are ultimately implemented effectively.

Key Publications

Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Tilly Eichler, Bernhard Michalowsky, Adina Dreier-Wolfgramm, Ina Zwingmann, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann. Effectiveness and safety of dementia care management in primary care: A randomized clinical trial. JAMA Psychiatry. 2017 Sep 30; 74:996-1004. doi: 10.1001/jamapsychiatry.2017.2124
Diana Wucherer, Tilly Eichler, Johannes Hertel, Ingo Kilimann, Steffen Richter, Bernhard Michalowsky, Jochen René Thyrian, Stefan Teipel, Wolfgang Hoffmann. Potentially Inappropriate Medication in Community-Dwelling Primary Care Patients who were Screened Positive for Dementia. Journal of Alzheimer's Disease. 2016 Dec 31; 55:691-701. doi: 10.3233/JAD-160581
van den Berg N, Grabe HJ, Baumeister SE, Freyberger HJ, Hoffmann W. A Telephoneand Text Message-Based Telemedicine Concept for Patients with Mental Health Disorders: Results of a Randomized Controlled Trial. Psychother Psychosom. 2015 Jan 01; 84:82-89. doi: 10.1159/000369468
Tilly Eichler, Jochen René Thyrian, Johannes Hertel, Leonore Köhler, Diana Wucherer, Adina Dreier, Bernhard Michalowsky, Stefan Teipel, Wolfgang Hoffmann. Rates of formal diagnosis in people screened positive for dementia in primary care: Results of the DelpHi-trial. Journal of Alzheimer's Disease. 2013 Dec 31; 42:451-458. doi: 10.3233/JAD-140354
Bernhard Michalowsky, Tilly Eichler, Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Sebastian Laufs, Steffen Fleßa, Wolfgang Hoffmann. Medication cost of persons with dementia in primary care in Germany. Journal of Alzheimer's Disease. 2013 Dec 31; 42:949-958. doi: 10.3233/JAD-140804


Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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