Marina Boccardi
Late translational dementia research
Dr. Marina Boccardi
Group Leader
Gehlsheimer Str. 20
18147  Rostock

marina.boccardi@dzne.de
 +49 381 4949-479

Research areas/focus

Similar to other diseases, also for neurocognitive disorders only a small portion of the research progress affects clinical practice. Hurdles are due to a variety of reasons, ranging from logistical, to methodological and cultural ones. The aim of the Late-Translational Dementia Research group consists of tackling these hurdles as systematically as possible, to increase translation effectiveness. Specific methods include methodological pipelines entailing all development phases (from basic research to implementation), like the 5-phase biomarker validation roadmap, consensus procedures, as well as structuring the involvement of pertinent stakeholders and end-users not only at the latest translational steps, but also from early clinical research. By keeping in mind how our research should impact clinical practice at all steps of the translational continuum, we can design better studies and increase cost-effectiveness of dementia research. The activities of the Late-Translational Dementia Research group are conceived in tight synergy with those of the Clinical Dementia Research and of the Translational Health Care Research groups at DZNE-Rostock-Greifswald.

Past work included taking neuropsychology-based rehabilitation techniques to caregivers of people with neurocognitive disorders, defining standard operating procedures and clinical guidelines for the use of diagnostic biomarkers in clinical research and practice, and importing from other medical fields the methodology for the systematic validation and implementation of diagnostic biomarkers. The next goals consist of adapting these validation methods to new biomarkers (e.g., markers of tauopathy), to harmonize specific portions of the diagnostic procedure (e.g., the neuropsychological assessment for the diagnosis of MCI) or adapting these methods to different contexts of use (e.g., case finding).

Effective implementation requires that the different actors involved in the different research steps be aware of the above issues and of the most effective methods. Thus, current research is also aimed to build and structure this kind of interdisciplinary collaboration.

Key Publications

Boccardi M, Nicolosi V, Festari C, Bianchetti A, Cappa S, Chiasserini D, Falini A, Guerra UP, Nobili F, Padovani A, Sancesario G, Morbelli S, Parnetti L, Tiraboschi P, Muscio C, Perani D, Pizzini FB, Beltramello A, Salvini Porro G, Ciaccio M, Schillaci O, Trabucchi M, Tagliavini F, Frisoni GB. Italian consensus recommendations for a biomarker-based aetiological diagnosis in mild cognitive impairment patients. Eur J Neurol. 2019 Nov 06; doi: 10.1111/ene.14117
F. Nobili, J. Arbizu, F. Bouwman, A. Drzezga, F. Agosta, P. Nestor, Z. Walker, Boccardi. European Association of Nuclear Medicine and European Academy of Neurology recommendations for the use of brain 18 F-fluorodeoxyglucose positron emission tomography in neurodegenerative cognitive impairment and dementia: Delphi consensus. European Journal of Neurology. 2018 Sep 30; 25:1201-1217. doi: 10.1111/ene.13728
Giovanni B Frisoni, Marina Boccardi, Frederik Barkhof, Kaj Blennow, Stefano Cappa, Konstantinos Chiotis, Jean-Francois Démonet, Valentina Garibotto, Panteleimon Giannakopoulos, Anton Gietl, Oskar Hansson, Karl Herholz, Clifford R Jack, Flavio Nobili, Agneta Nordberg, Heather M Snyder, Mara Ten Kate, Andrea Varrone, Emiliano Albanese, Stefanie Becker, Patrick Bossuyt, Maria C Carrillo, Chiara Cerami, Bruno Dubois, Valentina Gallo, Ezio Giacobini, Gabriel Gold, Samia Hurst, Anders Lönneborg, Karl-Olof Lovblad, Niklas Mattsson, José-Luis Molinuevo, Andreas U Monsch, Urs Mosimann, Alessandro Padovani, Agnese Picco, Corinna Porteri, Osman Ratib, Laure Saint-Aubert, Charles Scerri, Philip Scheltens, Jonathan M Schott, Ida Sonni, Stefan Teipel, Paolo Vineis, Pieter Jelle Visser, Yutaka Yasui, Bengt Winblad. Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers. The Lancet Neurology. 2017 Jul 31; 16:661-676. doi: 10.1016/S1474-4422(17)30159-X
Giovanni B. Frisoni, Clifford R. Jack, Martina Bocchetta, Corinna Bauer, Kristian S. Frederiksen, Yawu Liu, Gregory Preboske, Tim Swihart, Melanie Blair, Enrica Cavedo, Michel J. Grothe, Mariangela Lanfredi, Oliver Martinez, Masami Nishikawa, Marileen Portegies, Travis Stoub, Chadwich Ward, Liana G. Apostolova, Rossana Ganzola, Dominik Wolf, Frederik Barkhof, George Bartzokis, Charles DeCarli, John G. Csernansky, Leyla Detoledo-Morrell, Mirjam I. Geerlings, Jeffrey Kaye, Ronald J. Killiany, Stephane Lehericy, Hiroshi Matsuda, John O'Brien, Lisa C. Silbert, Philip Scheltens, Hilkka Soininen, Stefan Teipel, Gunhild Waldemar, Andreas Fellgiebel, Josephine Barnes, Michael Firbank, Lotte Gerritsen, Wouter Henneman, Nikolai Malykhin, Jens C. Pruessner, Lei Wang, Craig Watsonl, Henrike Wolf, Mony Deleon, Johannes Pantel, Clarissa Ferrari, Paolo Bosco, Patrizio Pasqualetti, Simon Duchesne, Henri Duvernoy, Marina Boccardi. The EADC-ADNI harmonized protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity. Alzheimer's and Dementia. 2014 Dec 31; 11:111-125. doi: 10.1016/j.jalz.2014.05.1756
Boccardi M, Bocchetta M, Apostolova LG, Barnes J, Bartzokis G, Corbetta G, DeCarli C, deToledo-Morrell L, Firbank M, Ganzola R, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pasqualetti P, Pruessner JC, Redolfi A, Robitaille N, Soininen H, Tolomeo D, Wang L, Watson C, Wolf H, Duvernoy H, Duchesne S, Jack CR Jr, Frisoni GB; EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. Alzheimers Dement. 2015 Feb 01; 11:126-38. doi: 10.1016/j.jalz.2014.02.009

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