Protein aggregation and neuroinflammation are two hallmarks of neurodegenerative diseases. Accumulating data indicate that peripheral immunity multifaceted interact with central nervous system (CNS) during disease pathogenesis and progression. We have observed a potential neurotoxic role of brain-infiltrating T cells in association with disease progression in a C9orf72 ALS/FTD animal model. However, the detailed function of these brain-infiltrating T cells and their multifaceted interactions with microglia and neurons in CNS are largely unknown. My group aim to a) characterize brain-infiltrating T cells, b) reveal alternation of their function and crosstalk with CNS resident cells such as microglia and neurons, and c) explore the therapeutical potential in the context of C9orf72 ALS/FTD using cutting edge flow cytometry analysis, cell culture models and transgenic animal models.