Natalia Rodriguez-Muela
Selective Neuronal Vulnerability in Neurodegenerative Diseases
Dr. Natalia Rodriguez-Muela
Group Leader
Tatzberg 41
01307  Dresden


The complete list of publications can be found here.

Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs R, Norabuena E, Perrimon N, Singh R, Rubin LL. Blocking p62/SQSTM1- dependent SMN degradation ameliorates the Spinal Muscular Atrophy disease phenotype. J Clin Invest. 2018 Jul 02; 127:3008-3023. doi: 10.1172/JCI95231
Boya P, Codogno P, Rodriguez-Muela N. Autophagy in stem cells: repair, remodeling, and metabolic reprogramming. Development. 2018 Feb 26; 145 doi: 10.1242/dev.146506
Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem Cell Reports. 2017 Aug 08; 9:667-680. doi: 10.1016/j.stemcr.2017.06.008
Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez A. Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 2017 Jun 22; 60:4983-5001. doi: 10.1021/acs.jmedchem.7b00395
Rodriguez-Muela N1*, Litterman NK1, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LL. Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease. Cell Reports. 2017 Feb 07; 18:1484-1498. doi: 10.1016/j.celrep.2017.01.035
Ng SY1, Soh BS1, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LL. Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell. 2015 Nov 05; 17:569-84. doi: 10.1016/j.stem.2015.08.003
Rodríguez-Muela N, Hernández-Pinto AM, et al. Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa. Cell Death Differ. 2015 Mar 01; 22:476-87. doi: 10.1038/cdd.2014.203
Rodríguez-Muela N, Koga H, et al. Balance between autophagic pathways preserves retinal homeostasis. Aging Cell. 2019 Aug 02; 12:478-88. doi: 10.1111/acel.12072
Rodríguez-Muela N, Germain F, et al. Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice. Cell Death Differ. 2019 Aug 02; 19:162-9. doi: 10.1038/cdd.2011.88
Dehay B, Bové J, Rodríguez-Muela N, et al. Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci. 2010 Sep 15; 30:12535-44. doi: 10.1523/JNEUROSCI.1920-10.2010


Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

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