Microglia and Neuroinflammation
Dr. Annett Halle
Group Leader
Venusberg-Campus 1/99
53127  Bonn

 +49 228 43302-475


The complete list of publications is found here.

Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, Fuhrmann M, Henneberger C, Halle A, Petzold GC. P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model. J Exp Med. 2018 May 03; pii: jem.20171487 [Epub ahead of print] doi: 10.1084/jem.20171487
Plescher M, Seifert G, Hansen JN, Bedner P, Steinhäuser C, Halle A. Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model. Glia. 2018 Mar 01; [Epub ahead of print] doi: 10.1002/glia.23318
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M Ransohoff, Karl Herrup, Sally A Frautschy, Bente Finsen, Guy C Brown, Alexei Verkhratsky, Koji Yamanaka, Jari Koistinaho, Eicke Latz, Annett Halle, Gabor C Petzold, Terrence Town, Dave Morgan, Mari L Shinohara, V Hugh Perry, Clive Holmes, Nicolas G Bazan, David J Brooks, Stéphane Hunot, Bertrand Joseph, Nikolaus Deigendesch, Olga Garaschuk, Erik Boddeke, Charles A Dinarello, John C Breitner, Greg M Cole, Douglas T Golenbock, Markus P Kummer. Neuroinflammation in Alzheimer's disease. The Lancet Neurology. 2014 Dec 31; 14:388-405. doi: 10.1016/S1474-4422(15)70016-5
Schnaars M, Beckert H, Halle A. Assessing beta-amyloid-induced NLRP3 inflammasome activation in primary microglia. Methods in molecular biology. 2013 Jan 01; 1040:1-8. doi: 10.1007/978-1-62703-523-1_1
Krabbe G*, Halle A*, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, et al. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PloS one. 2013 Jan 01; 8:e60921. doi: 10.1371/journal.pone.0060921
Michael T. Heneka, Markus P. Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T. Golenbock. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Feb 06; 494:674-678.
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010 Jan 01; 11:155-61. doi: 10.1038/ni.1836
Zhou S*, Halle A*, Kurt-Jones EA, Cerny AM, Porpiglia E, Rogers M, et al. Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses. J Neuroimmunol. 2008 Jan 01; 194:70-82. doi: 10.1016/j.jneuroim.2007.11.018
Jain V, Halle A, Halmen KA, Lien E, Charrel-Dennis M, Ram S, et al. Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling. Blood. 2008 Jan 01; 111:4637-45. doi: 10.1182/blood-2007-11-126862
Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008 Jan 01; 9:847-56. doi: 10.1038/ni.1631
Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008 Jan 01; 9:857-65. doi: 10.1038/ni.1636
Bermpohl D*, Halle A*, Freyer D, Dagand E, Braun JS, Bechmann I, et al. Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest. 2005 Jan 01; 115:1607-15. doi: 10.1172/jci23223


Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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