Susanne Wegmann
Protein Actions in Neurodegeneration
Susanne Wegmann, PhD, Dipl.-Ing.
Group Leader
c/o Charite Universitaetsmedizin Berlin
Chariteplatz 1
10117  Berlin
 +49 30 450-539834


The complete list of publications is found here.

Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Experimental evidence for the age dependence of tau protein spread in the brain. Sci Adv. 2019 Jun 26; 5:eaaw6404. doi: 10.1126/sciadv.aaw6404
Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstetter. Biomolecular condensation of the microtubule-associated protein tau. Semin Cell Dev Biol. 2020 Mar 01; 99:202-214. doi: 10.1016/j.semcdb.2019.06.007
Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, Alyssa Coyne, Julia Schiantarelli, Yari Carlomagno, Casey Cook, Sean J. Miller, Simon Dujardin, Ana S. Amaral, Jonathan C. Grima, Rachel E. Bennett, Katharina Tepper, Michael DeTure, Charles R. Vanderburgh, Bianca T. Corjuc, Sarah L. DeVos, Jose Antonio Gonzalez, Jeannie Chew, Svetlana Vidensky, Fred H. Gage, Jerome Mertens, Juan Troncoso, Eckhard Mandelkow, Xavier Salvatella, Roderick Y.H. Lim, Leonard Petrucelli, Susanne Wegmann, Jeffrey D. Rothstein, Bradley T. Hyman. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 Sep 04; 99:925-940.e7. doi: 10.1016/j.neuron.2018.07.039
Susanne Wegmann, Bahareh Eftekharzadeh, Katharina Tepper, Katarzyna M Zoltowska, Rachel E Bennett, Simon Dujardin, Pawel R Laskowski, Danny MacKenzie, Tarun Kamath, Caitlin Commins, Charles Vanderburg, Allyson D Roe, Zhanyun Fan, Amandine M Molliex, Amayra Hernandez-Vega, Daniel Muller, Anthony A Hyman, Eckhard Mandelkow, J Paul Taylor, Bradley T Hyman. Tau protein liquid–liquid phase separation can initiate tau aggregation. EMBO Journal. 2018 Apr 02; 37 doi: 10.15252/embj.201798049
Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher, Luc Buee. Atypical, non-standard functions of the microtubule associated Tau protein. Acta neuropathologica communications. 2017 Nov 28; 5:91. doi: 10.1186/s40478-017-0489-6
Wegmann S, Bennett RE, Amaral AS, Hyman BT. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods Cell Biol. 2017 Jan 01; 141:307-322. doi: 10.1016/bs.mcb.2017.06.014
Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase. Cell Rep. 2017 Sep 05; 20:2304-2312. doi: 10.1016/j.celrep.2017.08.042
Wegmann S, Nicholls S, Takeda S, Fan Z, Hyman BT. Formation, release, and internalization of stable tau oligomers in cells. J Neurochem. 2016 Dec 01; 139:1163-1174. doi: 10.1111/jnc.13866
Eftekharzadeh B, Hyman BT, Wegmann S. Structural studies on the mechanism of protein aggregation in age related neurodegenerative diseases. Mech Ageing Dev. 2016 Jun 01; 156:1-13. doi: 10.1016/j.mad.2016.03.001
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J. 2015 Dec 14; 34:3028-41. doi: 10.15252/embj.201592748
Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proc Natl Acad Sci U S A. 2014 Jan 07; 111:510-4. doi: 10.1073/pnas.1318807111
Wegmann S, Medalsy ID, Mandelkow E, Müller DJ. The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proc Natl Acad Sci U S A. 2013 Jan 22; 110:E313-21. doi: 10.1073/pnas.1212100110
Wegmann S, Jung YJ, Chinnathambi S, Mandelkow EM, Mandelkow E, Muller DJ. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem. 2010 Aug 27; 285:27302-13. doi: 10.1074/jbc.M110.145318


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