Genome Dynamics in Neurodegenerative Diseases
Dr. Farahnaz Sananbenesi
Group leader
Von-Siebold-Str. 3
37075 Göttingen

farahnaz.sananbenesi@dzne.de
 +49 551 39-61213

Areas of investigation/research focus

Dr. Sananbenesi investigates the interplay of environmental and genetic factors in the pathogenesis of brain diseases. One line of research addresses the question why for example neuropsychiatric diseases such as post-traumatic stress disorder increase the risk to develop  dementia at old age.  The identification of biomarker for early detection of neurodegenerative diseases is another key aspect of her research. This approach is motivated by the hypothesis that even already available therapeutic approaches will be effective when applied at an early stage of the disease to well-stratified patients. The analysis of circulating small non coding RNAs is one promising line of research in this endeavor.

Key Publications

Roberto Carlos Agís-Balboa, Paulo S Pinheiro, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahari-Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer, Farahnaz Sananbenesi. Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia. EMBO Journal. 2017 Oct 01; 36:2815-2828. doi: 10.15252/embj.201796821
Bahari-Javan S, Varbanov H, Halder R, Benito E,…Sananbenesi F, Fischer A. Hdac1 as a target for individualized therapy of schizophrenia patients. Proc Natl Acad Sci U S A. 2017 Jan 01; 114:E4686-E469.
Sanaz Bahari-Javan, Andrea Maddalena, Cemil Kerimoglu, Jessica Wittnam, Torsten Held, Mathias Bähr, Susanne Burkhardt, Ivanna Delalle, Sebastian Kügler, Andre Fischer, Farahnaz Sananbenesi. HDAC1 regulates fear extinction in mice. Journal of Neuroscience. 2012 Apr 10; 32:5062-5073. doi: 10.1523/JNEUROSCI.0079-12.2012
Peleg S*, Sananbenesi F*, Zovoilis A*, Burkhardt S, Bahari-Javan S, Agis-Balboa, RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhoffer M, Farinelli L, Chen W, Fischer A (*equal contribution). Altered histone H4 lysine 12 acetylation is associated with age-dependent memory impairment in mice. Science. 2010 Jan 01; 328:753.
Sananbenesi F, Fischer A, Wang X, Schrick C, Neve R, Radulovic J, et al. A hippocampal Cdk5 pathway regulates the extinction of contextual fear. Nat Neurosci. 2007 Jan 01; 10:1012-9. doi: 10.1038/nn1943

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