Synaptic Connectivity and Neurodegeneration
Prof. Dr. Dr. Pierluigi Nicotera
Scientific Director and Group Leader
Sigmund-Freud-Str. 27
Gebäude 99
53127 Bonn
 +49 228 43302-602


The complete list of publications is found here.

Valeria Amodeo, Deli, Joanne Betts, Stefano Bartesaghi, Ying Zhang, Angela Richard-Londt, Matthew Ellis, Rozita Roshani, Mikaella Vouri, Sara Galavotti, Sarah Oberndorfer, Ana Paula Leite, Alan Mackay, Aikaterini Lampada, Eva Wessel Stratford, Ningning Li, David Dinsdale, David Grimwade, Chris Jones, Pierluigi Nicotera, David Michod, Sebastian Brandner, Paolo Salomoni. A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS. Cell Reports. 2017 Jul 10; 20:411-426. doi: 10.1016/j.celrep.2017.06.047
Piazzesi A, Papić D, Bertan F, Salomoni P, Nicotera P, Bano D. Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. Cell Rep. 2016 Oct 18; 17:987-996. doi: 10.1016/j.celrep.2016.09.074
Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P. Loss of apoptosis-inducing factor critically affects MIA40 function. Cell Death Dis. 2015 Jul 09; 6:e1814. doi: 10.1038/cddis.2015.170
Bartesaghi S, Graziano V, Galavotti S, Henriquez N, Betts J, Saxena J, Karlsson A, Martins LM, Capasso M, Nicotera P, Brandner S, De Laurenzi V, Salomoni P. Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. Proc Natl Acad Sci USA. ; 112:1059-1064. doi: 10.1073/pnas.1413165112
Roberta Tufi, Sonia Gandhi, Inês P. De Castro, Susann Lehmann, Plamena R. Angelova, David Dinsdale, Emma Deas, Hélène Plun-Favreau, Pierluigi Nicotera, Andrey Y. Abramov, Anne E. Willis, Giovanna R. Mallucci, Samantha H. Y. Loh, L. Miguel Martins. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nature Cell Biology. 2014 Jan 31; 16:157-166. doi: 10.1038/ncb2901
David Michod, Stefano Bartesaghi, Amel Khelifi, Cristian Bellodi, Laura Berliocchi, Pierluigi Nicotera, Paolo Salomoni. Calcium-Dependent Dephosphorylation of the Histone Chaperone DAXX Regulates H3.3 Loading and Transcription upon Neuronal Activation. Neuron. 2012 Apr 11; 74:122-135. doi: 10.1016/j.neuron.2012.02.021
Elena Ziviani, Giordano Lippi, Daniele Bano, Eliana Munarriz, Stefania Guiducci, Michele Zoli, Kenneth W. Young, Pierluigi Nicotera. Ryanodine receptor-2 upregulation and nicotine-mediated plasticity. EMBO Journal. 2011 Jan 04; 30:194-204. doi: 10.1038/emboj.2010.279
Regad T, Bellodi C, Nicotera P, Salomoni P. The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci. 2009 Jan 01; 12:132-140. doi: 10.1038/nn.2251
Berliocchi L, Fava E, Leist M, Horvat V, Dinsdale D, Read D, Nicotera P. Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis. J Cell Biol. 2005 Feb 14; 168:607-18.
Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P. Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell. 2005 Jan 28; 120:275-85.
Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol. 2003 Jul 01; 4:552-65.
Schierle GS, Hansson O, Leist M, Nicotera P, Widner H, Brundin P. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nat Med. 1999 Jan 01; 5:97-100.
Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med. 1997 Apr 21; 185:1481-6.
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A. 1995 Aug 01; 92:7162-6.
Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 1995 Oct 01; 15:961-73.


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