Frank Heppner
Prof. Dr. Frank Heppner
Group Leader
Charitéplatz 1
10117  Berlin
 +49 30 450-536041


The complete list of publications is found here.

Prokop S, Miller KR, Drost N, Handrick S, Mathur V, Luo J, Wegner A, Wyss-Coray T, Heppner FL. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. J Exp Med. 2015 Jan 01; 212:1811-8. doi: 10.1084/jem.20150479
Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015 Jan 01; 16:358-72. doi: 10.1038/nrn3880
Krabbe G*, Halle A*, Matyash V, Rinnenthal JL, Eom GD, Bernhardt U, et al. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PloS one. 2013 Jan 01; 8:e60921. doi: 10.1371/journal.pone.0060921
Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nature Medicine. 2012 Jan 01; 18:1812-9. doi: 10.1038/nm.2965
Locatelli G, Wörtge S, Buch T, Ingold B, Frommer F, Sobottka B, Krüger M, Karram K, Bühlmann C, Bechmann I, Heppner FL, Waisman A, Becher B. Primary oligodendrocyte death does not elicit anti-CNS immunity. Nature Neuroscience. 2012 Jan 01; 15:543-50. doi: 10.1038/nn.3062
Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL*, Jucker M*. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 2009 Jan 01; 12:1361-3. doi: 10.1038/nn.2432
Falsig J, Julius C, Margalith I, Schwarz P, Heppner FL, Aguzzi A. A versatile prion replication assay in organotypic brain slices. Nature Neuroscience. 2008 Jan 01; 11:109-17. doi: 10.1038/nn2028
Buch T, Heppner FL, Tertilt C, Heinen TJAJ, Kremer M, Wunderlich FT, Jung S, Waisman A. A Cre-Inducible Toxin Receptor Mediates Cell Lineage Ablation Following Diphtheria Toxin Administration. Nature Methods. 2005 Jan 01; 2:419-26. doi: 10.1038/nmeth762
Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, Becher B, Aguzzi A. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nature Medicine. 2005 Jan 01; 11:146-152. doi: 10.1038/nm1177
Greter M, Heppner FL, Durell B, Lemos MP, Odermatt BM, Goebels N, Laufer T, Noelle RJ, Becher B. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nature Medicine. 2005 Jan 01; 11:328-334. doi: 10.1038/nm1197
Heppner FL, Christ AD, Klein MA, Prinz M, Fried M, Kraehenbuhl JP, Aguzzi A. Transepithelial prion transport by M cells. Nature Medicine. 2001 Jan 01; 9:976-977. doi: 10.1038/nm0901-976


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