Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

Hampel H, Lista S, Teipel SJ, Garaci F, Nisticò R, Blennow K, Zetterberg H, Bertram L, Duyckaerts C, Bakardjian H, Drzezga A, Colliot O, Epelbaum S, Broich K, Lehéricy S, Brice A, Khachaturian ZS, Aisen PS, Dubois B. Biochem Pharmacol. 2014 Apr 15;88(4):426-49. doi: 10.1016/j.bcp.2013.11.009. Epub 2013 Nov 22.


open PubMed Abstract

Minor cognitive disturbances in X-linked spinal and bulbar muscular atrophy, Kennedy's disease

Kasper E, Wegrzyn M, Marx I, Korp C, Kress W, Benecke R, Teipel SJ, Prudlo J.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Mar;15(1-2):15-20. doi: 10.3109/21678421.2013.837927. Epub 2013 Nov 8.

 


open Pubmed Abstract

Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease.

Morgen K, Ramirez A, Frölich L, Tost H, Plichta MM, Kölsch H, Rakebrandt F, Rienhoff O, Jessen F, Peters O, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Hampel H, Teipel SJ, Pantel J, Heuser I, Wiltfang J, Rüther E, Kornhuber J, Maier W, Meyer-Lindenberg A.

Alzheimers Dement. 2014 Mar 6. pii: S1552-5260(13)02912-9. doi: 10.1016/j.jalz.2013.11.001. [Epub ahead of print]

 


open Pubmed Abstract

Diffusion tensor imaging in Alzheimer's disease and affective disorders.

Teipel SJ, Walter M, Likitjaroen Y, Schönknecht P, Gruber O.

Eur Arch Psychiatry Clin Neurosci. 2014 Mar 5. [Epub ahead of print]

 


open Pubmed Abstract

Chronic diseases in pregnant women: Prevalence and birth outcomes based on the SNiP-study

Kersten I, Lange AE, Haas JP, Fusch C, Lode H, Hoffmann W, Thyrian JR.

BMC Pregnancy Childbirth. 2014 Feb 19;14:75. doi: 10.1186/1471-2393-14-75.

 


open Pubmed Abstract

Dementia care management: going new ways in ambulant dementia care within a GP-based randomized controlled intervention trial

Eichler T, Thyrian JR, Dreier A, Wucherer D, Köhler L, Fiß T, Böwing G, Michalowsky B, Hoffmann W.

Int Psychogeriatr. 2014 Feb


open Pubmed abstract

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.

Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME, Bauer M, Bearden CE, Bergmann O, Binder EB, Blangero J, Bockholt HJ, Bøen E, Bois C, Boomsma DI, Booth T, Bowman IJ, Bralten J, Brouwer RM, Brunner HG, Brohawn DG, Buckner RL, Buitelaar J, Bulayeva K, Bustillo JR, Calhoun VD, Cannon DM, Cantor RM, Carless MA, Caseras X, Cavalleri GL, Chakravarty MM, Chang KD, Ching CR, Christoforou A, Cichon S, Clark VP, Conrod P, Coppola G, Crespo-Facorro B, Curran JE, Czisch M, Deary IJ, de Geus EJ, den Braber A, Delvecchio G, Depondt C, de Haan L, de Zubicaray GI, Dima D, Dimitrova R, Djurovic S, Dong H, Donohoe G, Duggirala R, Dyer TD, Ehrlich S, Ekman CJ, Elvsåshagen T, Emsell L, Erk S, Espeseth T, Fagerness J, Fears S, Fedko I, Fernández G, Fisher SE, Foroud T, Fox PT, Francks C, Frangou S, Frey EM, Frodl T, Frouin V, Garavan H, Giddaluru S, Glahn DC, Godlewska B, Goldstein RZ, Gollub RL, Grabe HJ, Grimm O, Gruber O, Guadalupe T, Gur RE, Gur RC, Göring HH, Hagenaars S, Hajek T, Hall GB, Hall J, Hardy J, Hartman CA, Hass J, Hatton SN, Haukvik UK, Hegenscheid K, Heinz A, Hickie IB, Ho BC, Hoehn D, Hoekstra PJ, Hollinshead M, Holmes AJ, Homuth G, Hoogman M, Hong LE, Hosten N, Hottenga JJ, Hulshoff Pol HE, Hwang KS, Jack CR Jr, Jenkinson M, Johnston C, Jönsson EG, Kahn RS, Kasperaviciute D, Kelly S, Kim S, Kochunov P, Koenders L, Krämer B, Kwok JB, Lagopoulos J, Laje G, Landen M, Landman BA, Lauriello J, Lawrie SM, Lee PH, Le Hellard S, Lemaître H, Leonardo CD, Li CS, Liberg B, Liewald DC, Liu X, Lopez LM, Loth E, Lourdusamy A, Luciano M, Macciardi F, Machielsen MW, Macqueen GM, Malt UF, Mandl R, Manoach DS, Martinot JL, Matarin M, Mather KA, Mattheisen M, Mattingsdal M, Meyer-Lindenberg A, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meisenzahl E, Melle I, Milaneschi Y, Mohnke S, Montgomery GW, Morris DW, Moses EK, Mueller BA, Muñoz Maniega S, Mühleisen TW, Müller-Myhsok B, Mwangi B, Nauck M, Nho K, Nichols TE, Nilsson LG, Nugent AC, Nyberg L, Olvera RL, Oosterlaan J, Ophoff RA, Pandolfo M, Papalampropoulou-Tsiridou M, Papmeyer M, Paus T, Pausova Z, Pearlson GD, Penninx BW, Peterson CP, Pfennig A, Phillips M, Pike GB, Poline JB, Potkin SG, Pütz B, Ramasamy A, Rasmussen J, Rietschel M, Rijpkema M, Risacher SL, Roffman JL, Roiz-Santiañez R, Romanczuk-Seiferth N, Rose EJ, Royle NA, Rujescu D, Ryten M, Sachdev PS, Salami A, Satterthwaite TD, Savitz J, Saykin AJ, Scanlon C, Schmaal L, Schnack HG, Schork AJ, Schulz SC, Schür R, Seidman L, Shen L, Shoemaker JM, Simmons A, Sisodiya SM, Smith C, Smoller JW, Soares JC, Sponheim SR, Sprooten E, Starr JM, Steen VM, Strakowski S, Strike L, Sussmann J, Sämann PG, Teumer A, Toga AW, Tordesillas-Gutierrez D, Trabzuni D, Trost S, Turner J, Van den Heuvel M, van der Wee NJ, van Eijk K, van Erp TG, van Haren NE, van 't Ent D, van Tol MJ, Valdés Hernández MC, Veltman DJ, Versace A, Völzke H, Walker R, Walter H, Wang L, Wardlaw JM, Weale ME, Weiner MW, Wen W, Westlye LT, Whalley HC, Whelan CD, White T, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Zilles D, Zwiers MP, Thalamuthu A, Schofield PR, Freimer NB, Lawrence NS, Drevets W; the Alzheimer’s Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group. Brain Imaging Behav. 2014 Jan 8. [Epub ahead of print]


open PubMed Abstract

Ethical and legal issues when dealing with genetic incidental findings-challenges and possible solutions

Rudnik-Schöneborn S, Langanke M, Erdmann P, Robienski J. Ethik in der Medizin 26 (2)pp.105-119 (2014).


Detecting the effect of Alzheimer's disease on everyday motion behavior.

Kirste T, Hoffmeyer A, Koldrack P, Bauer A, Schubert S, Schröder S, Teipel S. J Alzheimers Dis. 2014 Jan 1;38(1):121-32. doi: 10.3233/JAD-130272.


open PubMed Abstract

Does an interdisciplinary network improve dementia care? Results from the IDemUck-Study

Köhler L, Meinke-Franze C, Hein J, Fendrich K, Heymann R, Thyrian JR, Hoffmann W.

Curr Alzheimer Res. 2014;11(6):538-48.

 


open Pubmed Abstract

Rates of formal diagnosis in people screened positive for dementia in primary care: Results of the DelpHi-trial

Eichler T, Thyrian JR, Hertel J, Köhler L, Wucherer D, Dreier A, Michalowsky B, Teipel S, Hoffmann W.

J Alzheimers Dis. 2014;42(2):451-8. doi: 10.3233/JAD-140354.

 


open Pubmed Abstract

Medication cost of persons with dementia in primary care in Germany

Michalowsky B, Eichler T, Thyrian JR, Hertel J, Wucherer D, Laufs S, Fleßa S, Hoffmann W.

J Alzheimers Dis. 2014 Jan 1;42(3):949-58. doi: 10.3233/JAD-140804.

 


open Pubmed Abstract

Screening for hypopituitarism in 509 patients with traumatic brain injury or subarachnoid hemorrhage.

Kopczak A, Kilimann I, von Rosen F, Krewer C, Schneider HJ, Stalla GK, Schneider M. J Neurotrauma. 2014 Jan 1;31(1):99-107. doi: 10.1089/neu.2013.3002. Epub 2013 Dec 11.


open PubMed Abstract

Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus.

Teipel SJ, Flatz W, Ackl N, Grothe M, Kilimann I, Bokde AL, Grinberg L, Amaro E Jr, Kljajevic V, Alho E, Knels C, Ebert A, Heinsen H, Danek A.

Psychiatry Res. 2014 Mar 30;221(3):187-94. doi: 10.1016/j.pscychresns.2013.10.003. Epub 2013 Dec 6.

 


open Pubmed Abstract

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020.

Hampel H, Lista S, Teipel SJ, Garaci F, Nisticò R, Blennow K, Zetterberg H, Bertram L, Duyckaerts C, Bakardjian H, Drzezga A, Colliot O, Epelbaum S, Broich K, Lehéricy S, Brice A, Khachaturian ZS, Aisen PS, Dubois B. Biochem Pharmacol. 2013 Nov 22. pii: S0006-2952(13)00740-5. doi: 10.1016/j.bcp.2013.11.009. [Epub ahead of print]


open PubMed Abstract

Association of basal forebrain volumes and cognition in normal aging.

Wolf D, Grothe M, Fischer FU, Heinsen H, Kilimann I, Teipel S, Fellgiebel A. Neuropsychologia. 2013 Nov 21;53C:54-63. doi: 10.1016/j.neuropsychologia.2013.11.002. [Epub ahead of print]


open PubMed Abstract

Decline of fiber tract integrity over the adult age range: A diffusion spectrum imaging study.

Teipel S.J, Lerche M, Kilimann I, O'Brien K, Grothe M, Meyer P, Li X, Sänger P, Hauenstein K. Journal of Magnetic Resonance Imaging 2013


open Abstract

Measurement and genetics of human subcortical and hippocampal asymmetries in large datasets.

Guadalupe T, Zwiers M.P, Teumer A, Wittfeld K, Vasquez A.A, Hoogman M, Hagoort P, Fernandez G, Buitelaar J, Hegenscheid K, Völzke H, Franke B, Fisher S.E, Grabe H.J, Francks C. Human Brain Mapping 2013.


open Abstract

Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study.

Schuster C, Kasper E, Machts J, Bittner D, Kaufmann J, Benecke R, Teipel S, Vielhaber S, Prudlo J. J Neurol. 2013 Nov;260(11):2856-64. doi: 10.1007/s00415-013-7083-z. Epub 2013 Aug 31.


open PubMed Abstract

Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease.

Teipel S, Heinsen H, Amaro E Jr, Grinberg LT, Krause B, Grothe M; Alzheimer's Disease Neuroimaging Initiative. Neurobiol Aging. 2013 Oct 28. pii: S0197-4580(13)00431-4. doi: 10.1016/j.neurobiolaging.2013.09.029. [Epub ahead of print]


open PubMed Abstract

Molekulare Bildgebung in der Diagnostik von Demenzen [Article in German]

Kurth J, Kilimann I, Krause B.J, Teipel S. Nervenheilkunde. Volume 32, Issue 10, 2013, Pages 725-732


open Abstract

Dementia Care Manager for patients with dementia : Determination of the requirements and qualifications contents for nurses in the DelpHi-MV study.

[Article in German]

Dreier A, Hoffmann W. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Oct;56(10):1398-409. doi: 10.1007/s00103-013-1796-0.


open PubMed Abstract

Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.

de Souza Silva MA, Lenz B, Rotter A, Biermann T, Peters O, Ramirez A, Jessen F, Maier W, Hüll M, Schröder J, Frölich L, Teipel S, Gruber O, Kornhuber J, Huston JP, Müller CP, Schäble S. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15097-102. doi: 10.1073/pnas.1306884110. Epub 2013 Aug 27.


open PubMed Abstract

Characterisation of Nuclear Architectural Alterations during In Vitro Differentiation of Human Stem Cells of Myogenic Origin.

Rozwadowska N, Kolanowski T, Wiland E, Siatkowski M, Pawlak P, Malcher A, Mietkiewski T, Olszewska M, Kurpisz M. PLoS One. 2013 Sep 3;8(9):e73231. doi: 10.1371/journal.pone.0073231.


open PubMed Abstract

Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study.

Schuster C, Kasper E, Machts J, Bittner D, Kaufmann J, Benecke R, Teipel S, Vielhaber S, Prudlo J. J Neurol. 2013 Aug 31. [Epub ahead of print]


open PubMed Abstract