Generating new neurons to circumvent your fears: the role of IGF signaling.

Agis-Balboa RC, Fischer A. Cell Mol Life Sci. 2013 Mar 30. [Epub ahead of print]


open PubMed Abstract

ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.

Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro T, Looger L, Bähr M, Zweckstetter M, Kügler S. Ann Neurol. 2013 Mar 28. doi: 10.1002/ana.23905. [Epub ahead of print]


open PubMed Abstract

Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice.

Kerimoglu C, Agis-Balboa RC, Kranz A, Stilling R, Bahari-Javan S, Benito-Garagorri E, Halder R, Burkhardt S, Stewart AF, Fischer A. J Neurosci. 2013 Feb 20;33(8):3452-64. doi: 10.1523/JNEUROSCI.3356-12.2013.


open PubMed Abstract

Conserved amyloid core structure of stop mutants of the human prion protein.

Zweckstetter M. Prion. 2013 May 1;7(3):193-7. doi: 10.4161/pri.23956. Epub 2013 Feb 13.


open PubMed Abstract

Mechanistic Basis of Phenothiazine-Driven Inhibition of Tau Aggregation.

Akoury E, Pickhardt M, Gajda M, Biernat J, Mandelkow E, Zweckstetter M. Angew Chem Int Ed Engl. 2013 Mar 18;52(12):3511-5. doi: 10.1002/anie.201208290. Epub 2013 Feb 11.


open PubMed Abstract

Cold denaturation of a protein dimer monitored at atomic resolution

Jaremko M, Jaremko L, Kim HY, Cho MK, Schwieters CD, Giller K, Becker S, Zweckstetter M. Nat Chem Biol. 2013 Apr;9(4):264-70. doi: 10.1038/nchembio.1181. Epub 2013 Feb 10.


open PubMed Abstract

N-h spin-spin couplings: probing hydrogen bonds in proteins.

Xiang SQ, Narayanan RL, Becker S, Zweckstetter M. Angew Chem Int Ed Engl. 2013 Mar 18;52(12):3525-8. doi: 10.1002/anie.201209641. Epub 2013 Feb 10.


open PubMed Abstract

Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors

Hasan A, Mitchell A, Schneider A, Halene T, Akbarian S. Eur Arch Psychiatry Clin Neurosci. 2013 Feb 5. [Epub ahead of print]


open PubMed Abstract

Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors.

Hasan A, Mitchell A, Schneider A, Halene T, Akbarian S. Eur Arch Psychiatry Clin Neurosci. 2013 Jun;263(4):273-84. doi: 10.1007/s00406-013-0395-2. Epub 2013 Feb 5.


open PubMed Abstract

Inhibition of tau filament formation by conformational modulation.

Akoury E, Gajda M, Pickhardt M, Biernat J, Soraya P, Griesinger C, Mandelkow E, Zweckstetter M. J Am Chem Soc. 2013 Feb 20;135(7):2853-62. doi: 10.1021/ja312471h. Epub 2013 Feb 5.


open PubMed Abstract

Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants.

Skora L, Fonseca-Ornelas L, Hofele RV, Riedel D, Giller K, Watzlawik J, Schulz-Schaeffer WJ, Urlaub H, Becker S, Zweckstetter M. J Biol Chem. 2013 Feb 1;288(5):2994-3002. doi: 10.1074/jbc.M112.423715. Epub 2012 Dec 3.


open PubMed Abstract

Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients

Banigan MG, Kao PF, Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, Delalle I. PLoS One. 2013;8(1):e48814. doi: 10.1371/journal.pone.0048814. Epub 2013 Jan 30.


open PubMed Abstract

Loss of HDAC5 impairs memory function: Implications for Alzheimer's disease

Agis-Balboa RC, Pavelka Z, Kerimoglu C, Fischer A. J Alzheimers Dis. 2013;33(1):35-44. doi: 10.3233/JAD-2012-121009.


open PubMed Abstract

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schlüter OM, Bradke F, Lu J, Fischer A. EMBO Mol Med. 2013 Jan;5(1):52-63. doi: 10.1002/emmm.201201923. Epub 2012 Nov 26.


open PubMed Abstract

Imbalance of Hsp70 family variants fosters tau accumulation.

Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. FASEB J. 2013 Apr;27(4):1450-9. doi: 10.1096/fj.12-220889. Epub 2012 Dec 27.


open PubMed Abstract

Neurobiology of severe psychiatric disorders - New approaches in the molecular research landscape.

Reich-Erkelenz D, Schmitt A, Gruber O, Dechent P, Brockmöller J, Tzvetkov M, Fischer A, Bickeböller H, Rossner M, Nave K, Falkai P, Schulze TG. Psychatrie. 2012; 9 (1) pp. 14-24.


open Abstract

Determination of amyloid core structure using chemical shifts

Skora L, Zweckstetter M. Protein Sci. 2012 Dec;21(12):1948-53. doi: 10.1002/pro.2170. Epub 2012 Oct 26.


open PubMed Abstract

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation.

Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, López-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, Schrader T, Zweckstetter M, Pfeifer A, Lashuel HA, Muhs A. J Biol Chem. 2012 Oct 5;287(41):34786-800. doi: 10.1074/jbc.M112.357665. Epub 2012 Aug 13.


open PubMed Abstract

Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H. PLoS One. 2012;7(9):e45024. doi: 10.1371/journal.pone.0045024. Epub 2012 Sep 21.


open PubMed Abstract

Mapping the potential energy landscape of intrinsically disordered proteins at amino Acid resolution.

Ozenne V, Schneider R, Yao M, Huang JR, Salmon L, Zweckstetter M, Jensen MR, Blackledge M. J Am Chem Soc. 2012 Sep 12;134(36):15138-48. Epub 2012 Aug 28.


open PubMed Abstract

Methylation of Lysine 9 in Histone H3 Directs Alternative Modes of Highly Dynamic Interaction of Heterochromatin Protein hHP1β with the Nucleosome.

Munari F, Soeroes S, Zenn HM, Schomburg A, Kost N, Schröder S, Klingberg R, Rezaei-Ghaleh N, Stützer A, Gelato KA, Walla PJ, Becker S, Schwarzer D, Zimmermann B, Fischle W, Zweckstetter M. J Biol Chem. 2012 Sep 28;287(40):33756-65. Epub 2012 Jul 19.


open PubMed Abstract

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

Daebel V, Chinnathambi S, Biernat J, Schwalbe M, Habenstein B, Loquet A, Akoury E, Tepper K, Müller H, Baldus M, Griesinger C, Zweckstetter M, Mandelkow E, Vijayan V, Lange A. J Am Chem Soc. 2012 Aug 29;134(34):13982-9. doi: 10.1021/ja305470p. Epub 2012 Aug 15.


open PubMed Abstract

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders.

Schneider A, Simons M. Cell Tissue Res. 2013 Apr;352(1):33-47. doi: 10.1007/s00441-012-1428-2. Epub 2012 May 19.


open PubMed Abstract

HDAC1 Regulates Fear Extinction in Mice.

Bahari-Javan S, Maddalena A, Kerimoglu C, Wittnam J, Held T, Bähr M, Burkhardt S, Delalle I, Kügler S, Fischer A, Sananbenesi F. J Neurosci. 2012 Apr 11;32(15):5062-5073.


open PubMed Abstract

Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statins.

Schneider A, Simons M. J Neurochem. 2012 Jan;120(1):1-3. doi: 10.1111/j.1471-4159.2011.07548.x.


open PubMed Abstract