Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β

Munari F, Gajda MJ, Hiragami-Hamada K, Fischle W, Zweckstetter M.

FEBS Lett. 2014 Apr 2;588(7):1094-9. doi: 10.1016/j.febslet.2014.02.019. Epub 2014 Feb 20.

 


open Pubmed Abstract

Hsp90-tau complex reveals molecular basis for specificity in chaperone action

Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG.

Cell. 2014 Feb 27;156(5):963-74. doi: 10.1016/j.cell.2014.01.037.

 


open Pubmed Abstract

Loss of Prion Protein Leads to Age-Dependent Behavioral Abnormalities and Changes in Cytoskeletal Protein Expression.

Schmitz M, Greis C, Ottis P, Silva CJ, Schulz-Schaeffer WJ, Wrede A, Koppe K, Onisko B, Requena JR, Govindarajan N, Korth C, Fischer A, Zerr I.

Mol Neurobiol. 2014 Mar 7. [Epub ahead of print]

 


open Pubmed Abstract

Internalization routes of cell-penetrating melanoma antigen peptides into human dendritic cells.

Buhl T, Braun A, Forkel S, Möbius W, van Werven L, Jahn O, Rezaei-Ghaleh N, Zweckstetter M, Mempel M, Schön MP, Haenssle HA. Exp Dermatol. 2014 Jan;23(1):20-6. doi: 10.1111/exd.12285.


open PubMed Abstract

Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering.

Schwalbe M, Ozenne V, Bibow S, Jaremko M, Jaremko L, Gajda M, Jensen MR, Biernat J, Becker S, Mandelkow E, Zweckstetter M, Blackledge M. Structure. 2014 Feb 4;22(2):238-49. doi: 10.1016/j.str.2013.10.020. Epub 2013 Dec 19.


open PubMed Abstract

Phosphorylation of human tau protein by microtubule affinity-regulating kinase 2.

Schwalbe M, Biernat J, Bibow S, Ozenne V, Jensen MR, Kadavath H, Blackledge M, Mandelkow E, Zweckstetter M. Biochemistry. 2013 Dec 17;52(50):9068-79. doi: 10.1021/bi401266n. Epub 2013 Nov 22.


open PubMed Abstract

MicroRNAs as biomarkers for CNS disease.

Rao P, Benito E, Fischer A. Front Mol Neurosci. 2013 Nov 26;6:39.


open PubMed Abstract

Association of prion protein genotype and scrapie prion protein type with cellular prion protein charge isoform profiles in cerebrospinal fluid of humans with sporadic or familial prion diseases.

Schmitz M, Lüllmann K, Zafar S, Ebert E, Wohlhage M, Oikonomou P, Schlomm M, Mitrova E, Beekes M, Zerr I. Neurobiol Aging. 2014 May;35(5):1177-88. doi: 10.1016/j.neurobiolaging.2013.11.010. Epub 2013 Nov 16.


open PubMed Abstract

NMR structural studies of the first catalytic half-domain of ubiquitin activating enzyme.

Jaremko M, Jaremko L, Nowakowski M, Wojciechowski M, Szczepanowski RH, Panecka R, Zhukov I, Bochtler M, Ejchart A. J Struct Biol. 2013 Nov 6. pii: S1047-8477(13)00299-2. doi: 10.1016/j.jsb.2013.10.020. [Epub ahead of print]


open PubMed Abstract

The metallacrowns as templates for spontaneous self-assembly of polypeptides into a tetrahelical bundle.

Cal M, Jaremko L, Jaremko M, Stefanowicz P. New Journal of Chemistry; Volume 37, Issue 11, November 2013, Pages 3770-3777.


open Abstract

Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins.

Xiang S, Gapsys V, Kim HY, Bessonov S, Hsiao HH, Möhlmann S, Klaukien V, Ficner R, Becker S, Urlaub H, Lührmann R, de Groot B, Zweckstetter M. Structure. 2013 Oct 30. pii: S0969-2126(13)00365-1. doi: 10.1016/j.str.2013.09.014. [Epub ahead of print]


open PubMed Abstract

Predicting the rotational tumbling of dynamic multidomain proteins and supramolecular complexes.

Rezaei-Ghaleh N, Klama F, Munari F, Zweckstetter M. Angew Chem Int Ed Engl. 2013 Oct 18;52(43):11410-4. doi: 10.1002/anie.201305094. Epub 2013 Sep 2.


open PubMed Abstract

Insulin growth factor binding protein 7 is a novel target to treat dementia.

Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A. Neurobiol Dis. 2014 Feb;62:135-43. doi: 10.1016/j.nbd.2013.09.011. Epub 2013 Sep 25.


open PubMed Abstract

PrP mRNA and protein expression in brain and PrPc in CSF in Creutzfeldt-Jakob disease MM1 and VV2.

Llorens F, Ansoleaga B, Garcia-Esparcia P, Zafar S, Grau-Rivera O, López-González I, Blanco R, Carmona M, Yagüe J, Nos C, Del Río JA, Gelpí E, Zerr I, Ferrer I. Prion. 2013 Sep 18;7(5). [Epub ahead of print]


open PubMed Abstract

Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H. Mol Psychiatry. 2013 Sep 3. doi: 10.1038/mp.2013.110. [Epub ahead of print]


open PubMed Abstract

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition

Lopez-Atalaya JP, Ito S, Valor LM, Benito E, Barco A. Nucleic Acids Res. 2013 Sep 1;41(17):8072-84. doi: 10.1093/nar/gkt590. Epub 2013 Jul 1.


open PubMed Abstract

Spongiform encephalopathy in siblings with no evidence of protease-resistant prion protein or a mutation in the prion protein gene.

Varges D, Schulz-Schaeffer WJ, Wemheuer WM, Damman I, Schmitz M, Cramm M, Kallenberg K, Shirneshan K, Elkenani M, Markwort S, Faist M, Kohlhase J, Windl O, Zerr I. J Neurol. 2013 Jul;260(7):1871-9. doi: 10.1007/s00415-013-6897-z. Epub 2013 Apr 2.


open PubMed Abstract

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.

Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S. Ann Neurol. 2013 Jul;74(1):109-18. doi: 10.1002/ana.23905. Epub 2013 Aug 6.


open PubMed Abstract

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.

Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM. PLoS Biol. 2013 Jul;11(7):e1001604. doi: 10.1371/journal.pbio.1001604. Epub 2013 Jul 9.


open PubMed Abstract

Enhanced β-turn conformational stability of tripeptides containing ΔPhe in cis over trans configuration.

Jaremko M, Jaremko L, Mazur A, Makowski M, Lisowski M. Amino Acids. 2013 Jun 28. [Epub ahead of print]


open PubMed Abstract

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork.

Aggarwal S, Snaidero N, Pähler G, Frey S, Sánchez P, Zweckstetter M, Janshoff A, Schneider A, Weil MT, Schaap IA, Görlich D, Simons M. PLoS Biol. 2013 Jun;11(6):e1001577. doi: 10.1371/journal.pbio.1001577. Epub 2013 Jun 4.


open PubMed Abstract

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits.

Bouter Y, Dietrich K, Wittnam JL, Rezaei-Ghaleh N, Pillot T, Papot-Couturier S, Lefebvre T, Sprenger F, Wirths O, Zweckstetter M, Bayer TA. Acta Neuropathol. 2013 May 18. [Epub ahead of print]


open PubMed Abstract

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.

Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A. Acta Neuropathol. 2013 Jun;125(6):795-813. doi: 10.1007/s00401-013-1114-9. Epub 2013 Apr 19.


open PubMed Abstract

Structural plasticity in human heterochromatin protein 1β.

Munari F, Rezaei-Ghaleh N, Xiang S, Fischle W, Zweckstetter M. PLoS One. 2013 Apr 9;8(4):e60887. doi: 10.1371/journal.pone.0060887. Print 2013.


open PubMed Abstract

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog glia.

Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M. Cell Stem Cell. 2013 Apr 4;12(4):426-39. doi: 10.1016/j.stem.2013.01.019.


open PubMed Abstract