Markus Zweckstetter
Translationale strukturelle Biologie der Demenz
Prof. Dr. Markus Zweckstetter
Gruppenleiter
Von-Siebold-Str. 3a
37075 Göttingen

markus.zweckstetter@dzne.de
 +49 551 39-61181

Publikationen

Die vollständige Publikationsliste findet man hier.

Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D, Zweckstetter M. Lysine/RNA-interactions drive and regulate biomolecular condensation. Nat Commun. 2019 Jul 02; 10:2909. doi: 10.1038/s41467-019-10792-y
Javier Oroz, Bliss J. Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V. Hofele, Jeremy D. Baker, Laura J. Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A. Dickey, Markus Zweckstetter. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature communications. 2018 Nov 30; 9 doi: 10.1038/s41467-018-06880-0
Marc Boehning, Claire Dugast-Darzacq, Marija Rankovic, Anders S. Hansen, Taekyung Yu, Herve Marie-Nelly, David T. McSwiggen, Goran Kokic, Gina M. Dailey, Patrick Cramer, Xavier Darzacq, Markus Zweckstetter. RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology. 2018 Aug 31; 25:833-840. doi: 10.1038/s41594-018-0112-y
Javier Oroz, Jin Hae Kim, Bliss J Chang, Markus Zweckstetter. Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology. 2017 Mar 31; 24:407-413. doi: 10.1038/nsmb.3380
Garima Jaipuria, Andrei Leonov, Karin Giller, Suresh Kumar Vasa, Áukasz Jaremko, Mariusz Jaremko, Rasmus Linser, Stefan Becker, Markus Zweckstetter. Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure. Nature Communications. 2017 Mar 29; 8 doi: 10.1038/ncomms14893
Susmitha Ambadipudi, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstetter. Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications. 2017 Nov 30; 8 doi: 10.1038/s41467-017-00480-0
Nasrollah Rezaei-Ghaleh, Mehriar Amininasab, Sathish Kumar, Jochen Walter, Markus Zweckstetter. Phosphorylation modifies the molecular stability of β-amyloid deposits. Nature Communications. 2016 Apr 12; 7 doi: 10.1038/ncomms11359
Kadavath H, Hofele RV, Biernat J, Kumar S, Tepper K, Urlaub H, et al. Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proc Natl Acad Sci U S A. 2015 Jan 01; 112:7501-6. doi: 10.1073/pnas.1504081112
Piotr Wysoczanski, Cornelius Schneider, Shengqi Xiang, Francesca Munari, Simon Trowitzsch, Markus C. Wahl, Reinhard Lührmann, Stefan Becker, Markus Zweckstetter. Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology. 2013 Dec 31; 21:911-918. doi: 10.1038/nsmb.2889
G. Elif Karagöz, Afonso M.S. Duarte, Elias Akoury, Hans Ippel, Jacek Biernat, Tania Morán Luengo, Martina Radli, Tatiana Didenko, Bryce A. Nordhues, Dmitry B. Veprintsev, Chad A. Dickey, Eckhard Mandelkow, Markus Zweckstetter, Rolf Boelens, Tobias Madl, Stefan G.D. Rüdiger. Hsp90-tau complex reveals molecular basis for specificity in chaperone action. Cell. 2014 Feb 26; 156:963-974. doi: 10.1016/j.cell.2014.01.037
Jaremko L, Jaremko M, Giller K, Becker S, Zweckstetter M. Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science. 2014 Jan 01; 343:1363-6. doi: 10.1126/science.1248725
Luis Fonseca-Ornelas, Sybille E. Eisbach, Maria Paulat, Karin Giller, Claudio O. Fernández, Tiago F. Outeiro, Stefan Becker, Markus Zweckstetter. Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation. Nature communications. 2013 Dec 31; 5:5857. doi: 10.1038/ncomms6857
Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Zweckstetter M, et al. Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol. 2009 Jan 01; 7:e34. doi: 10.1371/journal.pbio.1000034
Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, Zweckstetter M,et al. Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A. 2008 Jan 01; 105:15370-5. doi: 10.1073/pnas.0808115105
Mariusz Jaremko, Łukasz Jaremko, Hai-Young Kim, Min-Kyu Cho, Charles D Schwieters, Karin Giller, Stefan Becker, Markus Zweckstetter. Cold denaturation of a protein dimer monitored at atomic resolution. Nature Chemical Biology. 2013 Mar 31; 9:264-270. doi: 10.1038/nchembio.1181

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