TracInflam - Transition from acute to chronic neuroinflammation

Mission Statement

Neuroinflammation is the reaction of the immune system of the brain that occurs during various diseases of the central nervous system. Acute activation of microglia and astrocytes may harbour beneficial effects.Under circumstances not yet well understood, an acute/focal neuroinflammatory reaction turns into a chronic and spread type of immune activation. This transition from acute/focal to chronic and spread immune reaction is likely to have detrimental consequences for the brain and likely to contribute to the progression of exactly the disease, which initially had stimulated the immune reaction. Alternatively, chronic and spread inflammation may be self-originated. The present proposal will discriminate between these possibilities and study the mechanisms of transition between various stages of immune activation in preclinical models acrossvarious diseases that possess an inflammatory component. Moreover, we aim to identify gene network hubs that mark key steps of this transition in order to find points of intervention. Interference with such key steps will be tested. Moreover, we will validate our findings using human cerebrospinal fluid and brain tissue from intermediate phases of the respective disease. We strongly suggest that the results of this study will have wider implications for additional CNS disorders, which harbour an inflammatory component.

The internal workspace for consortium members can be found here.

Partners

Bertrand Joseph
Karolinska Institutet
Dept. of Oncology-Pathology
Stockholm, Sweden

Eran Segal
Weizmann Institute
Dept. of Computer Science and
Applied Mathematics
Rehovot, Israel

Severine Boillee
Ìnstitut du Cerveau et de la Moelle epinière
(ICM, brain and spinal cord institute)
Paris, France

Marie-Eve Tremblay
Laval University
Dept. of Molecular Medicine
CHU de Quebec Research Center
Quebec, Canada

Coordinator
Michael T. Heneka
German Center for Neurodegenerative Diseases and
University of Bonn
Dept. of Neurology
Bonn, Germany

This is a European Research Area Network (ERA-NET) NEURON project. The project is supported through the following organisations under the aegis of ERA-NET NEURON: Canada, Canadian Institutes of Health Research; France, Agence National de la Recherche; Germany, Federal Ministry of Education and Research (BMBF; funding code 01EW1508); Israel, Ministry of Health; Sweden, Swedish Research Council (VR).

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