Publikationen


Schmid B, Furthauer M, Connors SA, Trout J, Thisse B, Thisse C, et al. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development. 2000 Jan 01; 127:957-67.
Ott A, Stolk RP, van Harskamp F, Pols HAP, Hofman A, Breteler MMB. Diabetes mellitus and the risk of dementia – The Rotterdam Study. Neurology. 1999 Dec 10; 53:1937-42. doi: 10.1212/WNL.53.9.1937
van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.. Nat Neurosci. 1999 Mar 01; 2:266-70. doi: 10.1038/6368
Rizzu P, Van Swieten JC, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer MF, Hillebrand M, Ravid R, Oostra BA, Goedert M, van Duijn CM, Heutink P. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. Am J Hum Genet. 1999 Feb 02; 64:414-21.
Endres M, Fink K, Zhu J, Stagliano NE, Bondada V, Geddes JW, et al. Neuroprotective effects of gelsolin during murine stroke. J Clin Invest. 1999 Jan 01; 103:347-54. doi: 10.1172/JCI4953
Boecker H, Ceballos-Baumann A, Bartenstein P, Weindl A, Siebner HR, Fassbender T, et al. Sensory processing in Parkinson's and Huntington's disease: in-vestigations with 3D H(2)(15)O-PET. Brain. 1999 Jan 01; 122:1651-1665. doi: 10.1093/brain/122.9.1651
Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. Mechanism of the cleavage specificity of Alzheimer's disease gamma- secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc Natl Acad Sci USA. 1999 Jan 01; 96:3053-8.
Schierle GS, Hansson O, Leist M, Nicotera P, Widner H, Brundin P. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nat Med. 1999 Jan 01; 5:97-100.
Hutton M, Lendon CL, Rizzu P*, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd PR, Hayward N, Kwok JB, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P *joint first author. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998 Jun 18; 393:702-5.
Hutton, M, Lendon, CL, Rizzu, P, Baker, M, Froelich, S, ..., Heutink P. Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature. 1998 Jan 01; 393:702-5. doi: 10.1038/31508
Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, et al. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA. 1998 Jan 01; 95:8880-5.
Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med. 1997 Apr 21; 185:1481-6.
Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environment. Nature. 1997 Apr 03; 386:493-5. doi: 10.1038/386493a0
Kozielski F, Sack S, Marx A, Thormählen M, ..., Mandelkow E-M, Mandelkow E. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell. 1997 Jan 01; 91:985-94. doi: 10.1016/S0092-8674(00)80489-4
Boecker H, Wills AJ, Ceballos-Baumann A, Samuel M, Thomas DG, Marsden CD, et al. Stereotactic thalamotomy in tremor-dominant Parkinson's disease: an H2(15)O PET motor activation study. Ann Neurol. 1997 Jan 01; 41:108-111. doi: 10.1002/ana.410410118
Boecker H, Wills AJ, Ceballos-Baumann A, Samuel M, Thompson PD, Findley LJ, et al. The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann Neurol. 1996 Jan 01; 39:650-658. doi: 10.1002/ana.410390515
Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med. 1995 Dec 01; 1:1291-6.
Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 1995 Oct 01; 15:961-73.
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A. 1995 Aug 01; 92:7162-6.
Breteler MMB, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JHW, van Harskamp F, Tanghe HLJ, de Jong PTVM, van Gijn J, Hofman A. Cerebral white matter lesions, vascular risk factors and cognitive function in a population-based study. Neurology. 1994 Jul 01; 44:1246-52. doi: 10.1212/WNL.44.7.1246
Braak E, Braak H, Mandelkow E-M. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol. 1994 Jan 01; 87:554-67.
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, Selkoe DJ. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 1992 Nov 24; 359:322-5. doi: 10.1038/359322a0
Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 1992 Jun 22; 357:500-3. doi: 10.1038/357500a0
Gärtner J, Moser H, Valle D. Mutations in the 70 k peroxisomal membrane protein gene in Zellweger syndrome.. Nat Genet. 1992 Jan 01; 1:16-22.
Wille H, Drewes G, Biernat J, Mandelkow E-M, Mandelkow E. Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. J Cell Biol. 1992 Jan 01; 118:573-84.
Mandelkow E-M, Mandelkow E, Milligan RA. Microtubule dynamics and microtubule caps: A time-resolved cryo-electron microscopy study. J Cell Biol. 1991 Jan 01; 114:977-91.
Klockgether T, Turski L. NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats. Ann Neurol. 1990 Jan 01; 28:539-46. doi: 10.1002/ana.410280411
Mandelkow E, Mandelkow E-M, Hotani H, Hess B, Müller SC. Spatial patterns from oscillating microtubules. Science. 1989 Jan 01; 246:1291-3.
Mandelkow E-M, Harmsen A, Mandelkow E, Bordas J. X-ray kinetic studies of microtubule assembly using synchrotron radiation. Nature. 1980 Jan 01; 287:595-9.
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