Publikationen


Jackson WS, Tallaksen-Greene SJ, Albin RL, Detloff PJ. Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Hum Mol Genet. 2003 Jul 01; 12:1621-9.
Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol. 2003 Jul 01; 4:552-65.
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity. Nat Cell Biol. 2003 May 01; 5:486-8. doi: 10.1038/ncb960
Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MMB. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003 Mar 27; 348:1215-22. doi: 10.1056/NEJMoa022066
Bonifati, V, Rizzu, P, van Baren, MJ, Schaap, O, Breedveld, ..., Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003 Jan 01; 299:256-9. doi: 10.1126/science.1077209
Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D. Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest. 2003 Jan 01; 111:1537-45. doi: 10.1172/JCI16387
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of γ-secretase activity. Nat Cell Biol. 2003 Jan 01; 5:486-8. doi: 10.1038/ncb960
Vorberg I, Groschup MH, Pfaff E, Priola SA. Multiple amino acid residues within the rabbit prion protein inhibit formation of its abnormal isoform. J Virol. 2003 Jan 01; 77:2003-9.
David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG. Proteasomal degradation of tau protein. J Neurochem. 2002 Oct 01; 83:176-85.
Mellor J, Nicoll RA, Schmitz D. Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science. 2002 Jan 04; 295:143-7. doi: 10.1126/science.1064285
Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, ... , Priller J , et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. 2002 Jan 01; 8:831-40. doi: 10.1038/nm731
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, ..., Jucker M. Cerebral hemorrhage after passive anti-Aβ-immunotherapy. Science. 2002 Jan 01; 298:1379. doi: 10.1126/science.1078259
Mellor J, Nicoll RA, Schmitz D. Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science. 2002 Jan 01; 295:143-7. doi: 10.1126/science.1064285
Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, …, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production. Proc Natl Acad Sci U S A. 2002 Jan 01; 99:8025-30. doi: 10.1073/pnas.112686799
Vorberg I, Priola SA. Molecular basis of scrapie strain glycoform variation. J Biol Chem. 2002 Jan 01; 277:36775-81. doi: 10.1074/jbc.M206865200
in ‘t Veld, BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, Stijnen T, Breteler MMB, Stricker BHC. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s Disease. N Engl J Med. 2001 Nov 22; 345:1515-21. doi: 10.1056/NEJMoa010178
Zimprich A, Grabowski M, Asmus F, Naumann M, Berg D, Bertram M, Scheidtmann K, Kern P, Winkelmann J, Müller-Myhsok B, Riedel L, Bauer M, Müller T, Castro M, Meitinger T, Strom TM, Gasser T. Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus-dystonia syndrome. Nat Genet. 2001 Sep 01; 29:66-9. doi: 10.1038/ng709
Lin CH, Tallaksen-Greene S, Chien WM, Cearley JA, Jackson WS, Crouse AB, Ren S, Li XJ, Albin RL, Detloff PJ. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum Mol Genet. 2001 Jan 15; 10:137-44.
Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, et al. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med. 2001 Jan 01; 7:1356-61. doi: 10.1038/nm1201 -1356
Zhai R, Friedmon HV, Cases-Langhoff C, Beckers B, Gundelfinger ED, Ziv N, Garner CC. Assemblying the presynaptic active zone: Characterization of an Active zone precursor vesicle. Neuron. 2001 Jan 01; 29:131-143.
Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner CJ, Bauer M, Marto JA, Ampe C, Kinkl N, Ueffing M. QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Molecular & cellular proteomics. 2001 Jan 01; 10:M110 001172. doi: 10.1074/mcp.M110.001172
Heppner FL, Musahl C, Arrighi I, Klein MA, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science. 2001 Jan 01; 294:178-182. doi: 10.1126/science.1063093
Heppner FL, Christ AD, Klein MA, Prinz M, Fried M, Kraehenbuhl JP, Aguzzi A. Transepithelial prion transport by M cells. Nature Medicine. 2001 Jan 01; 9:976-977. doi: 10.1038/nm0901-976
Vorberg I, Chan K, Priola SA. Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform. J Virol. 2001 Jan 01; 75:10024-32. doi: 10.1128/JVI.75.21.10024-10032.2001
Rizzu P, Joosse M, Ravid R, Hoogeveen A, Kamphorst W, van Swieten JC, Willemsen R, Heutink P. Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients. Hum Mol Genet. 2000 Dec 12; 9:3075-82.
Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol. 2000 Nov 01; 2:848-51. doi: 10.1038/35041097
Dityatev A, Dityateva G, Schachner M. Synaptic strength as a function of post- versus presynaptic expression of the neural cell adhesion molecule NCAM. Neuron. 2000 Jan 01; 26:207-17. doi: 10.1016/S0896-6273(00)81151-4
von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow E-M, Mandelkow E. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif (306-VQIVYK-311) forming beta structure. Proc Natl Acad Sci USA. 2000 Jan 01; 97:5129-34. doi: 10.1073/pnas.97.10.5129
Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nat Cell Biol. 2000 Jan 01; 2:205-11. doi: 10.1038/35008626
Schmid B, Furthauer M, Connors SA, Trout J, Thisse B, Thisse C, et al. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development. 2000 Jan 01; 127:957-67.

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