Publikationen


Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2020 Dec 10; e105819 doi: 10.15252/embj.2020105819
Ruth E Uhlmann, Christine Rother, Jay Rasmussen, Juliane Schelle, Carina Bergmann, Emily M Ullrich Gavilanes, Sarah K Fritschi, Anika Buehler, Frank Baumann, Angelos Skodras, Rawaa Al-Shaana, Natalie Beschorner, Lan Ye, Stephan A Kaeser, Ulrike Obermüller, Søren Christensen, Fredrik Kartberg, Jeffrey B Stavenhagen, Jens-Ulrich Rahfeld, Holger Cynis, Fang Qian, Paul H Weinreb, Thierry Bussiere, Lary C Walker, Matthias Staufenbiel, Mathias Jucker. Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life. Nature Neuroscience. 2020 Dec 01; 23:1580-1588. doi: 10.1038/s41593-020-00737-w
Ferreira Castro A*, Baltruschat L, Stürner T, Bahrami A, Jedlicka P, Tavosanis G*, Cuntz H*. Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction. Elife. 2020 Nov 26; 9:e60920. doi: 10.7554/eLife.60920
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron. 2020 Oct 28; S0896-6273(20)30773-X doi: 0.1016/j.neuron.2020.10.005
Kreye J, Reincke SM, Kornau HC, Sánchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Höltje M, Dietert K, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Prüss H. A Therapeutic Non-self-reactive SARS- CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model. Cell. 2020 Sep 23; 183:1058-1069.e19. doi: 10.1016/j.cell.2020.09.049
Teipel SJ, Dyrba M, Chiesa PA, Sakr F, Jelistratova I, Lista S, et al. In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease. Neurobiology of aging. 2020 Sep 01; 93:98-108. doi: 10.1016/j.neurobiolaging.2020.03.011
Wolfsgruber S, Kleineidam L, Guski J, Polcher A, Frommann I, Roeske S, et al. Minor neuropsychological deficits in patients with subjective cognitive decline. Neurology. 2020 Sep 01; 95:e1134-43. doi: 10.1212/WNL.0000000000010142
Stoyanov S, Sun W, Düsedau HP, Cangalaya C, Choi I, Mirzapourdelavar H, Baidoe-Ansah D, Kaushik R, Neumann J, Dunay IR, Dityatev A. Attenuation of the extracellular matrix restores microglial activity during the early stage of amyloidosis. Glia. 2020 Aug 31; doi: 10.1002/glia.23894
Suzuki K, Elegheert J, Song I, Sasakura H, Senkov O, Matsuda K, Kakegawa W, Clayton AJ, Chang VT, Ferrer-Ferrer M, Miura E, Kaushik R, Ikeno M, Morioka Y, Takeuchi Y, Shimada T, Otsuka S, Stoyanov S, Watanabe M, Takeuchi K, Dityatev A, Aricescu AR, Yuzaki M. A synthetic synaptic organizer protein restores glutamatergic neuronal circuits. Science. 2020 Aug 28; 369::eabb4853. doi: 10.1126/science.abb4853
Labus J, Röhrs KF, Ackmann J, Varbanov H, Müller FE, Jia S, Jahreis K, Vollbrecht AL, Butzlaff M, Schill Y, Guseva D, Böhm K, Kaushik R, Bijata M, Marin P, Chaumont-Dubel S, Zeug A, Dityatev A, Ponimaskin E. Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor. Prog Neurobiol. 2020 Aug 22; 101900 doi: 10.1016/j.pneurobio.2020.101900
Cangalaya C, Stoyanov S, Fischer KD, Dityatev A. Light-induced engagement of microglia to focally remodel synapses in the adult brain. Elife. 2020 Aug 18; 9 doi: 10.7554/eLife.58435
Schulte-Schrepping J*, Reusch N*, Paclik D*, Baßler K*, Schlickeiser S*, Zhang B*, Krämer B*, Krammer T*, Brumhard S*, Bonaguro L*, De Domenico E*, Wendisch D*, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL+, Aschenbrenner AC+, Li Y+, Nattermann J+, Sawitzki B+, Saliba A-E+, Sander LE+, Deutsche COVID-19 OMICS Initiative (DeCOI). (*shared first, + senior author). Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell. 2020 Aug 01; doi: 10.1016/j.cell.2020.08.001
Heser K, Fink A, Reinke C, Wagner M, Doblhammer G. The temporal association between incident late‐life depression and incident dementia. Acta Psychiatrica Scandinavica. 2020 Jul 26; Online ahead of print doi: 10.3233/JAD-190770
Santos TE, Schaffran B, Broguière N, Meyn L, Zenobi-Wong M, Bradke F. Axon Growth of CNS Neurons in Three Dimensions Is Amoeboid and Independent of Adhesions. Cell Rep. 2020 Jul 21; 32:107907. doi: 10.1016/j.celrep.2020.107907
Teipel SJ, Fritz HC, Grothe MJ, Alzheimer s Disease Neuroimaging I. Neuropathological features associated with basal forebrain atrophy in Alzheimer's disease. Neurology. 2020 Jul 06; doi: 10.1212/WNL.0000000000010192
Kaushik R, Lipachev N, Matuszko G, Kochneva A, Dvoeglazova A, Becker A, Paveliev M, Dityatev A. Fine structure analysis of perineuronal nets in the ketamine model of schizophrenia. Eur J Neurosci. 2020 Jun 08; doi: 10.1111/ejn.14853
Mukherjee C, Kling T, Russo B, Miebach K, Kess E, Schifferer M, Pedro LD, Weikert U, Fard MK, Kannaiyan N, Rossner M, Aicher ML, Goebbels S, Nave KA, Krämer-Albers EM, Schneider A*, Simons M*. *Shared Senior Authorship. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metabolism. 2020 Jun 01;
Kleineidam L, Chouraki V, Próchnicki T, van der Lee SJ, Madrid-Márquez L, Wagner-Thelen H, et al. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment. Acta Neuropathologica. 2020 Jun 01; 139:1025-44. doi: 10.1007/s00401-020-02138-6
Wesselman LMP, van Lent DM, Schröder A, van de Rest O, Peters O, Menne F, et al. Dietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease. European Journal of Nutrition. 2020 May 29; Online ahead of print doi: 10.1007/s00394-020-02257-6
Schlachetzki JCM, Toda T*, Mertens J*. (*Co-corresponding). When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron. Exp Gerontol. 2020 May 01; 133 doi: 10.1016/j.exger.2020.110876
Luck T, Pabst A, Roehr S, Wiese B, Eisele M, Heser K, et al. Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study. International Psychogeriatrics. 2020 May 01; 32:645-59. doi: 10.1017/S1041610219001935
Nitzan N, McKenzie S, Beed P, English DF, Oldani S, Tukker JJ, Buzsáki G, Schmitz D. Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway. Nat Commun. 2020 Apr 23; 11:1947. doi: 10.1038/s41467-020-15787-8
Dyrba M, Mohammadi R, Grothe MJ, Kirste T, Teipel SJ. Gaussian Graphical Models Reveal Inter-Modal and Inter-Regional Conditional Dependencies of Brain Alterations in Alzheimer's Disease. Frontiers in aging neuroscience. 2020 Apr 21; 12:99. doi: 10.3389/fnagi.2020.00099
Goerss D, Hein A, Bader S, Halek M, Kernebeck S, Kutschke A, et al. Automated sensor-based detection of challenging behaviors in advanced stages of dementia in nursing homes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Apr 16; 16:672-80. doi: 10.1016/j.jalz.2019.08.193
Taylor JA, Hasegawa M, Benoit CM, Freire JA, Theodore M, Ganea DA, Lu T, Gründemann J. Single cell plasticity and population coding stability in auditory thalamus upon associative learning. bioRxiv. 2020 Apr 06; doi: 10.1101/2020.04.06.026401
Heser K, Kleineidam L, Pabst A, Wiese B, Roehr S, Löbner M, et al. Sex-Specific Associations Between Depressive Symptoms and Risk for Subsequent Dementia. Journal of Alzheimer’s Disease. 2020 Mar 10; 74:151-61. doi: 10.1111/acps.13220
Kornau HC, Kreye J, Stumpf A, Fukata Y, Parthier D, Sammons RP, Imbrosci B, Kurpjuweit S, Kowski AB, Fukata M, Prüss H, Schmitz D. Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability. Ann Neurol. 2020 Mar 01; 87:405-418. doi: 10.1002/ana.25666
Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstetter. Biomolecular condensation of the microtubule-associated protein tau. Semin Cell Dev Biol. 2020 Mar 01; 99:202-214. doi: 10.1016/j.semcdb.2019.06.007
Jessen F, Amariglio RE, Buckley RF, van der Flier WM, Han Y, Molinuevo JL, et al. The characterisation of subjective cognitive decline. The Lancet Neurology. 2020 Mar 01; 19:271-8. doi: 10.1016/S1474-4422(19)30368-0
Cursano S, Battaglia CR, Urrutia-Ruiz C, Grabrucker S, Schön M, Bockmann J, Braumüller S, Radermacher P, Roselli F, Huber-Lang M, Boeckers TM. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry. 2020 Feb 12; [Epub ahead of print] doi: 10.1038/s41380-020-0659-y

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