Angeborene Immunität in Neurodegeneration

Prof. Dr. Eicke Latz

Forschungsschwerpunkte

Many common diseases in modern societies are associated with an overactive innate immune system and chronic inflammation is part of the pathogenesis of the majority of non-communicable diseases.  Our major research aims are:

  • We focus on deciphering the molecular mechanisms of innate immune receptor activation using pharmacologic, biochemical and structural approaches.
  • We are particularly interested in understanding how innate receptors interact with their ligands leading to the most proximal signaling events.
  • We study the mechanisms by which cells sense nucleic acids and sterile danger signals by intracellular multi-molecular signaling complexes, termed inflammasomes.
  • We are investigating how innate immune activation contributes to the inflammatory responses in various conditions, such as atherosclerosis, Alzheimer’s disease, chronic eye diseases as well as metabolic diseases.
  • We perform a deep immune phenotyping analysis of the human immune system and perform functional genomics studies to elucidate novel mechanisms of immune activation and susceptibility to major inflammatory diseases.

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