Genom-Biologie neurodegenerativer Erkrankungen
Prof. Dr. Peter Heutink
Gruppenleiter und Standortsprecher
Professor für Genombiologie der neurodegenerativen Erkrankungen, Hertie-Institut für klinische Hirnforschung, Tübingen & Gastwissenschaftler am RIKEN-Zentrum für Life Science Technologies, Yokohama, Japan
Otfried-Müller-Str. 23
72076 Tübingen

peter.heutink@dzne.de
 +49 7071 9254-050

Publikationen

Die vollständige Publikationsliste findet man hier.

Iris E. Jansen, Hui Ye, Sasja Heetveld, Marie C. Lechler, Helen Michels, Renée I. Seinstra, Steven J. Lubbe, Valérie Drouet, Suzanne Lesage, Elisa Majounie, J.Raphael Gibbs, Mike A. Nalls, Mina Ryten, Juan A. Botia, Jana Vandrovcova, Javier Simon-Sanchez, Melissa Castillo-Lizardo, Patrizia Rizzu, Cornelis Blauwendraat, Amit K. Chouhan, Yarong Li, Puja Yogi, Najaf Amin, Cornelia M. van Duijn, Huw R. Morris, Alexis Brice, Andrew B. Singleton, Della C. David, Ellen A. Nollen, Shushant Jain, Joshua M. Shulman, Peter Heutink, Dena G. Hernandez, Sampath Arepalli, Janet Brooks, Ryan Price, Aude Nicolas, Sean Chong, Mark R. Cookson, Allissa Dillman, Matthew Moore, Bryan J. Traynor, Andrew B. Singleton, Vincent Plagnol, Nicholas W Wood, Una-Marie Sheerin, Jose M Bras, Gavin Charlesworth, Michelle Gardner, Rita Guerreiro, Daniah Trabzuni, John Hardy, Manu Sharma, Mohamad Saad, Javier Simón-Sánchez, Claudia Schulte, Jean Christophe Corvol, Alexandra Dürr, Marie Vidailhet, Sigurlaug Sveinbjörnsdóttir, Roger Barker, Caroline H Williams-Gray, Yoav Ben-Shlomo, Henk W. Berendse, Karin D. van Dijk, Daniela Berg, Kathrin Brockmann, Isabel Wurster, Walter Mätzler, Thomas Gasser, Maria Martinez, Rob M. A. de Bie, Alessandro Biffi, Daan Velseboer, Bas Bloem, Bart Post, Mirdhu Wickremaratchi, Bart van de Warrenburg, Zoltan Bochdanovits, Michael Bonin, Hjörvar Pétursson, Olaf Riess, David J. Burn, Steven Lubbe, J Mark Cooper, Alisdair McNeill, Anthony Schapira, Codrin Lungu, Honglei Chen, Jing Dong, Patrick F. Chinnery, Gavin Hudson, Carl E. Clarke, Catriona Moorby, Carl Counsell, Philippe Damier, Jean-François Dartigues, Panos Deloukas, Emma Gray, Sarah Edkins, Sarah E. Hunt, Simon Potter, Avazeh Tashakkori-Ghanbaria, Günther Deuschl, Delia Lorenz, David T. Dexter, Frank Durif, Jonathan R. Evans, Cordelia Langford, Thomas Foltynie, Alison Goate, Clare Harris, Jacobus J. van Hilten, Albert Hofman, Albert Hollenbeck, Janice Holton, Michele Hu, Xuemei Huang, Thomas Illig, Pálmi V. Jónsson, Jean-Charles Lambert, Sean S. O'Sullivan, Tamas Revesz, Karen Shaw, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Valentina Escott-Price, Justin Pearson, Nigel Williams, Ese Mudanohwo, Joel S. Perlmutter, Pierre Pollak, Fernando Rivadeneira, André G. Uitterlinden, Stephen Sawcer, Hans Scheffer, Ira Shoulson, Joshua Shulman, Colin Smith, Robert Walker, Chris C. A. Spencer, Amy Strange, Hreinn Stefánsson, Francesco Bettella, Kári Stefánsson, Joanna D. Stockton, Kevin Talbot, Carlie M. Tanner, François Tison, Sophie Winder-Rhodes, Kailash Bhatia. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology. 2017 Jan 29; 18 doi: 10.1186/s13059-017-1147-9
Cornelis Blauwendraat, Margherita Francescatto, J.Raphael Gibbs, Iris E. Jansen, Javier Simón-Sánchez, Dena G. Hernandez, Allissa A. Dillman, Andrew B. Singleton, Mark R. Cookson, Patrizia Rizzu, Peter Heutink. Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe. Genome Medicine. 2016 Jun 09; 8 doi: 10.1186/s13073-016-0320-1
Patrizia Rizzu, Cornelis Blauwendraat, Sasja Heetveld, Emily M. Lynes, Melissa Castillo-Lizardo, Ashutosh Dhingra, Elwira Pyz, Markus Hobert, Matthis Synofzik, Javier Simón-Sánchez, Margherita Francescatto, Peter Heutink. C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers. Acta neuropathologica communications. 2016 Apr 13; 4:37. doi: 10.1186/s40478-016-0306-7
Cornelis Blauwendraat, Carlo Wilke, Iris E. Jansen, Claudia Schulte, Javier Simón-Sánchez, Florian G. Metzger, Benjamin Bender, Thomas Gasser, Walter Maetzler, Patrizia Rizzu, Peter Heutink, Matthis Synofzik. Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants. Neurobiology of Aging. 2015 Dec 31; 37:208.e11-208.e17. doi: 10.1016/j.neurobiolaging.2015.09.016
Vavoulis DV, Francescatto M, Heutink P, Gough J. DGEclust: differential expression analysis of clustered count data. Genome Biol. 2015 Feb 20; 16:39. doi: 10.1186/s13059-015-0604-6
Mike A. Nalls, Nathan Pankratz, Christina M. Lill, Chuong B. Do, Dena G. Hernandez, Mohamad Saad, Anita L. Destefano, Eleanna Kara, Jose Bras, Manu Sharma, Claudia Schulte, Margaux F. Keller, Sampath Arepalli, Christopher Letson, Connor Edsall, Hreinn Stefansson, Xinmin Liu, Hannah Pliner, Joseph H. Lee, Rong Cheng, M. Arfan Ikram, John P.A. Ioannidis, Georgios M. Hadjigeorgiou, Joshua C. Bis, Maria Martinez, Joel S. Perlmutter, Alison Goate, Karen Marder, Brian Fiske, Margaret Sutherland, Georgia Xiromerisiou, Richard H. Myers, Lorraine N. Clark, Kari Stefansson, John A. Hardy, Peter Heutink, Honglei Chen, Nicholas W. Wood, Henry Houlden, Haydeh Payami, Alexis Brice, William K. Scott, Thomas Gasser, Lars Bertram, Nicholas Eriksson, Tatiana Foroud, Andrew B. Singleton. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics. 2013 Dec 31; 46:989-993. doi: 10.1038/ng.3043
Margherita Francescatto, Morana Vitezic, Peter Heutink, Alka Saxena. Brain-specific noncoding RNAs are likely to originate in repeats and may play a role in up-regulating genes in cis. International Journal of Biochemistry and Cell Biology. 2013 Dec 31; 54:331-337. doi: 10.1016/j.biocel.2014.06.014
Raffaele Ferrari, Dena G. Hernandez, Michael A. Nalls, Jonathan D. Rohrer, Adaikalavan Ramasamy, John B. J. Kwok, Carol Dobson-Stone, W.S. Brooks William S., Peter R. Schofield, Glenda M. Halliday, John R. Hodges, Olivier Piguet, Lauren Bartley, Elizabeth Thompson, Eric Haan, Isabel Hernández, Agustín Ruiz, Mercè Boada, Barbara Borroni, Alessandro Padovani, Carlos Cruchaga, Nigel J. Cairns, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Gianluigi Forloni, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Elio Scarpini, Jordi Clarimón, Alberto Lleó, Rafael Blesa, Maria Landqvist Waldö, Karin Nilsson, Christer Nilsson, Ian R. A. Mackenzie, Ging-Yuek R. Hsiung, David M. A. Mann, Jordan Grafman, Christopher M. Morris, Johannes Attems, Timothy D. Griffiths, Ian G. McKeith, Alan J. Thomas, Pietrini, Edward D. Huey, Eric M. Wassermann, Atik Baborie, Evelyn Jaros, Michael C. Tierney, Pau Pastor, Cristina Razquin, Sara Ortega-Cubero, Elena Alonso, Robert Perneczky, Janine Diehl-Schmid, Panagiotis Alexopoulos, Alexander Kurz, Innocenzo Rainero, Elisa Rubino, Lorenzo Pinessi, Ekaterina Rogaeva, Peter St George-Hyslop, Giacomina Rossi, Fabrizio Tagliavini, Giorgio Giaccone, James B. Rowe, Johannes C. M. Schlachetzki, James Uphill, John Collinge, Simon Mead, Adrian Danek, Vivianna M. Van Deerlin, Murray Grossman, John Q. Trojanowski, Julie Van der Zee, William Deschamps, Tim Van Langenhove, Marc Cruts, Christine Van Broeckhoven, Stefano F. Cappa, Isabelle Le Ber, Didier Hannequin, Véronique Golfier, Martine Vercelletto, Alexis Brice, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Irene Piaceri, Jørgen E. Nielsen, Lena E. Hjermind, Matthias Riemenschneider, Manuel Mayhaus, Bernd Ibach, Gilles Gasparoni, Sabrina Pichler, Wei Gu, Martin N. Rossor, Nick C. Fox, Jason D. Warren, Maria Grazia Spillantini, Huw R. Morris, Patrizia Rizzu, Peter Heutink, Julie S. Snowden, Sara Rollinson, Anna Richardson, Alexander Gerhard, Amalia C. Bruni, Raffaele Maletta, Francesca Frangipane, Chiara Cupidi, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Nicoletta Smirne, Rosa Rademakers, Matt Baker, Dennis W. Dickson, Neill R. Graff-Radford, Ronald C. Petersen, David Knopman, Keith A. Josephs, Bradley F. Boeve, Joseph E. Parisi, William W. Seeley, Bruce L. Miller, Anna M. Karydas, Howard Rosen, John C. van Swieten, Elise G. P. Dopper, Harro Seelaar, Yolande A. L. Pijnenburg, Philip Scheltens, Giancarlo Logroscino, Rosa Capozzo, Valeria Novelli, Annibale A. Puca, Massimo Franceschi, Alfredo Postiglione, Graziella Milan, Paolo Sorrentino, Mark Kristiansen, Huei-Hsin Chiang, Caroline Graff, Florence Pasquier, Adeline Rollin, Vincent Deramecourt, Florence Lebert, Dimitrios Kapogiannis, Luigi Ferrucci, Stuart Pickering-Brown, Andrew B. Singleton, John Hardy, Parastoo Momeni. Frontotemporal dementia and its subtypes: A genome-wide association study. The Lancet Neurology. 2013 Dec 31; 13:686-699. doi: 10.1016/S1474-4422(14)70065-1
FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furino M, Furusawa J, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JF, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-Sim A, Manabe R, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Noma S, Noazaki T, Ogishima S, Ohkura N, Ohimiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JG, Rackham OJ, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PA, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyodo H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verado R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y. A promoter-level mammalian expression atlas. Nature. 2014 Mar 27; 507:462-70. doi: 10.1038/nature13182
Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium., Forrest AR, Carninci P, Rehli M, Sandelin A. An atlas of active enhancers across human cell types and tissues. Nature. 2014 Mar 27; 507:455-61. doi: 10.1038/nature12787

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