Proteinaggregation und Altern
Dr. Della David
Gruppenleiterin
Otfried-Müller-Str. 23
72076 Tübingen

della.david@dzne.de
 +49 7071 9254-150

Publikationen

Die vollständige Publikationsliste findet man hier.

Groh N, Gallotta I, Lechler MC, Huang C, Jung R, David DC. Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans. J Vis Exp. 2017 Jan 01; 129:e56464. doi: 10.3791/56464
Marie C. Lechler, Della C. David. More stressed out with age? Check your RNA granule aggregation. Prion. 2017 Sep 02; 11:313-322. doi: 10.1080/19336896.2017.1356559
Groh N, Bühler A, Huang C, Li KW, van Nierop P, Smit AB, Fändrich M, Baumann F, David DC. Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation. Front Aging Neurosci. 2017 May 17; 9:138. doi: 10.3389/fnagi.2017.00138
Iris E. Jansen, Hui Ye, Sasja Heetveld, Marie C. Lechler, Helen Michels, Renée I. Seinstra, Steven J. Lubbe, Valérie Drouet, Suzanne Lesage, Elisa Majounie, J.Raphael Gibbs, Mike A. Nalls, Mina Ryten, Juan A. Botia, Jana Vandrovcova, Javier Simon-Sanchez, Melissa Castillo-Lizardo, Patrizia Rizzu, Cornelis Blauwendraat, Amit K. Chouhan, Yarong Li, Puja Yogi, Najaf Amin, Cornelia M. van Duijn, Huw R. Morris, Alexis Brice, Andrew B. Singleton, Della C. David, Ellen A. Nollen, Shushant Jain, Joshua M. Shulman, Peter Heutink, Dena G. Hernandez, Sampath Arepalli, Janet Brooks, Ryan Price, Aude Nicolas, Sean Chong, Mark R. Cookson, Allissa Dillman, Matthew Moore, Bryan J. Traynor, Andrew B. Singleton, Vincent Plagnol, Nicholas W Wood, Una-Marie Sheerin, Jose M Bras, Gavin Charlesworth, Michelle Gardner, Rita Guerreiro, Daniah Trabzuni, John Hardy, Manu Sharma, Mohamad Saad, Javier Simón-Sánchez, Claudia Schulte, Jean Christophe Corvol, Alexandra Dürr, Marie Vidailhet, Sigurlaug Sveinbjörnsdóttir, Roger Barker, Caroline H Williams-Gray, Yoav Ben-Shlomo, Henk W. Berendse, Karin D. van Dijk, Daniela Berg, Kathrin Brockmann, Isabel Wurster, Walter Mätzler, Thomas Gasser, Maria Martinez, Rob M. A. de Bie, Alessandro Biffi, Daan Velseboer, Bas Bloem, Bart Post, Mirdhu Wickremaratchi, Bart van de Warrenburg, Zoltan Bochdanovits, Michael Bonin, Hjörvar Pétursson, Olaf Riess, David J. Burn, Steven Lubbe, J Mark Cooper, Alisdair McNeill, Anthony Schapira, Codrin Lungu, Honglei Chen, Jing Dong, Patrick F. Chinnery, Gavin Hudson, Carl E. Clarke, Catriona Moorby, Carl Counsell, Philippe Damier, Jean-François Dartigues, Panos Deloukas, Emma Gray, Sarah Edkins, Sarah E. Hunt, Simon Potter, Avazeh Tashakkori-Ghanbaria, Günther Deuschl, Delia Lorenz, David T. Dexter, Frank Durif, Jonathan R. Evans, Cordelia Langford, Thomas Foltynie, Alison Goate, Clare Harris, Jacobus J. van Hilten, Albert Hofman, Albert Hollenbeck, Janice Holton, Michele Hu, Xuemei Huang, Thomas Illig, Pálmi V. Jónsson, Jean-Charles Lambert, Sean S. O'Sullivan, Tamas Revesz, Karen Shaw, Andrew Lees, Peter Lichtner, Patricia Limousin, Grisel Lopez, Valentina Escott-Price, Justin Pearson, Nigel Williams, Ese Mudanohwo, Joel S. Perlmutter, Pierre Pollak, Fernando Rivadeneira, André G. Uitterlinden, Stephen Sawcer, Hans Scheffer, Ira Shoulson, Joshua Shulman, Colin Smith, Robert Walker, Chris C. A. Spencer, Amy Strange, Hreinn Stefánsson, Francesco Bettella, Kári Stefánsson, Joanna D. Stockton, Kevin Talbot, Carlie M. Tanner, François Tison, Sophie Winder-Rhodes, Kailash Bhatia. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology. 2017 Jan 29; 18 doi: 10.1186/s13059-017-1147-9
Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC. Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. Cell Rep. 2017 Jan 10; 18:454-467. doi: 10.1016/j.celrep.2016.12.033
Della C. David. Aging and the aggregating proteome. Frontiers in Genetics. 2012 Nov 30; 3 doi: 10.3389/fgene.2012.00247
David DC, Ollikainen N, Trinidad JC, Cary MP, Burlingame AL, Kenyon C. Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol. 2010 Aug 10; 8:e1000450. doi: 10.1371/journal.pbio.1000450
David DC, Ittner LM, Gehrig P, Nergenau D, Shepherd C, Halliday G, Götz J. Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes. Proteomics. 2006 Dec 01; 6:6566-77.
David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dröse S, Brandt U, Müller WE, Eckert A, Götz J. Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem. 2005 Jun 24; 280:23802-14.
David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG. Proteasomal degradation of tau protein. J Neurochem. 2002 Oct 01; 83:176-85.

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