Impaired implicit learning and feedback processing after stroke

Lam JM, Globas C, Hosp JA, Karnath HO, Wächter T, Luft AR.

Neuroscience. 2016 Feb 9;314:116-24. doi: 10.1016/j.neuroscience.2015.11.051. Epub 2015 Nov 27.


open Pubmed abstract

Health-Related Quality of Life in patients with Parkinson's disease-A systematic review based on the ICF model

van Uem JM, Marinus J, Canning C, van Lummel R, Dodel R, Liepelt-Scarfone I, Berg D, Morris ME, Maetzler W.

Neurosci Biobehav Rev. 2016 Feb;61:26-34. doi: 10.1016/j.neubiorev.2015.11.014. Epub 2015 Dec 2. Review.


open Pubmed abstract

Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease

Blauwendraat C, Wilke C, Jansen IE, Schulte C, Simón-Sánchez J, Metzger FG, Bender B, Gasser T, Maetzler W, Rizzu P, Heutink P, Synofzik M.

Neurobiol Aging. 2016 Jan;37:208.e11-7. doi: 10.1016/j.neurobiolaging.2015.09.016. Epub 2015 Sep 30.


open Pubmed abstract

Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants

Blauwendraat C, Wilke C, Jansen IE, Schulte C, Simón-Sánchez J, Metzger FG, Bender B, Gasser T, Maetzler W, Rizzu P, Heutink P, Synofzik M.

Neurobiol Aging. 2016 Jan;37:208.e11-7. doi: 10.1016/j.neurobiolaging.2015.09.016. Epub 2015 Sep 30.


open Pubmed abstract

The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling

Drusenheimer N, Migdal B, Jäckel S, Tveriakhina L, Scheider K, Schulz K, Gröper J, Köhrer K, Klein T.

PLoS Genet. 2015 Dec 31;11(12):e1005749. doi: 10.1371/journal.pgen.1005749. eCollection 2015 Dec.


open Pubmed abstract

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus

Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Heutink P, Singleton AB, Brice A, Wood NW, Hardy J, Martinez M, Choi SH, DeStefano A, Ikram MA, Bis JC, Smith A, Fitzpatrick AL, Launer L, van Duijn C, Seshadri S, Ulstein ID, Aarsland D, Fladby T, Djurovic S, Hyman BT, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen OA, Dale AM; ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators.

Mol Psychiatry. 2015 Dec;20(12):1588-95. doi: 10.1038/mp.2015.6. Epub 2015 Feb 17.


open Pubmed abstract

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.

Mackenzie IR, Frick P, Grässer FA, Gendron TF, Petrucelli L, Cashman NR, Edbauer D, Kremmer E, Prudlo J, Troost D, Neumann M.

Acta Neuropathol. 2015 Dec;130(6):845-61. doi: 10.1007/s00401-015-1476-2. Epub 2015 Sep 15.


open Pubmed abstract

The spectrum of KIAA0196 variants, and characterization of a murine knockout: Implications for the mutational mechanism in hereditary spastic paraplegia type SPG8 Rare neurological diseases

Jahic A, Khundadze M, Jaenisch N, Schüle R, Klimpe S, Klebe S, Frahm C, Kassubek J, Stevanin G, Schöls L, Brice A, Hübner CA, Beetz C.

Orphanet J Rare Dis. 2015 Nov 16;10:147. doi: 10.1186/s13023-015-0359-x.


open Pubmed abstract

CSF biomarkers for the differential diagnosis of Alzheimer's disease. A large-scale international multicenter study

Ewers M, Mattsson N, Minthon L, Molinuevo JL, Antonell A, Popp J, Jessen F, Herukka SK, Soininen H, Maetzler W, Leyhe T, Bürger K, Taniguchi M, Urakami K, Lista S, Dubois B, Blennow K, Hampel H.

Alzheimers Dement. 2015 Nov;11(11):1306-15. doi: 10.1016/j.jalz.2014.12.006. Epub 2015 Mar 21.


open Pubmed Abstract

No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra

Schöls L, Reimold M, Seidel K, Globas C, Brockmann K, Hauser TK, Auburger G, Bürk K, den Dunnen W, Reischl G, Korf HW, Brunt ER, Rüb U.

Brain. 2015 Nov;138(Pt 11):3316-26. doi: 10.1093/brain/awv255. Epub 2015 Sep 11.


open Pubmed abstract

An Unsupervised Online Spike-Sorting Framework.

Knieling S, Sridharan KS, Belardinelli P, Naros G, Weiss D, Mormann F, Gharabaghi A.

Int J Neural Syst. 2015 Oct 27:1550042. [Epub ahead of print]


open Pubmed abstract

Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy

Osk Snorradottir A, Isaksson HJ, Kaeser SA, Skodras AA, Olafsson E, Palsdottir A, Thor Bragason B.

Brain Res. 2015 Oct 5;1622:149-62. doi: 10.1016/j.brainres.2015.06.019. Epub 2015 Jun 23.


open Pubmed abstract

Innovative genomic collaboration using the GENESIS (GEM.app) platform

Gonzalez M, Falk MJ, Gai X, Postrel R, Schüle R, Zuchner S.

Hum Mutat. 2015 Oct;36(10):950-6. doi: 10.1002/humu.22836. Epub 2015 Aug 12.


open Pubmed abstract

Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.

Simón-Sánchez J, Heutink P, Gasser T; International Parkinson's Disease Genomics Consortium (IPDGC).

Neurobiol Aging. 2015 Oct;36(10):2907.e13-7. doi: 10.1016/j.neurobiolaging.2015.07.008. Epub 2015 Jul 10.


open Pubmed abstract

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study

Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB; Parkinson's Disease Biomarkers Program and Parkinson's Progression Marker Initiative investigators.

Lancet Neurol. 2015 Oct;14(10):1002-9. doi: 10.1016/S1474-4422(15)00178-7. Epub 2015 Aug 10


open Pubmed abstract

α-Synuclein oligomers pump it up!

Kahle PJ, Sugeno N, Skodras A.

EMBO J. 2015 Oct 1;34(19):2385-7. doi: 10.15252/embj.201592770. Epub 2015 Sep 15. No abstract available.


open Pubmed abstract

Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency

Heinzel S, Metzger FG, Ehlis AC, Korell R, Alboji A, Haeussinger FB, Wurster I, Brockmann K, Suenkel U, Eschweiler GW, Maetzler W, Berg D, Fallgatter AJ.

PLoS One. 2015 Sep 22;10(9):e0138863. doi: 10.1371/journal.pone.0138863. eCollection 2015.


open Pubmed abstract

Parkinson's disease: From human genetics to clinical trials.

van der Brug MP, Singleton A, Gasser T, Lewis PA.

Sci Transl Med. 2015 Sep 16;7(305):205ps20. doi: 10.1126/scitranslmed.aaa8280. Review.


open Pubmed abstract

Genetics of Neurodegenerative Diseases (Article) [Genetik neurodegenerativer Erkrankungen]

Gasser, T. , Berg, D. in Aktuelle Neurologie, Volume 42, Issue 7, 16 September 2015, Pages 385-392


no abstract available

The CACNA1B R1389H variant is not associated with myoclonus-dystonia in a large European multicentric cohort

Mencacci NE, R'bibo L, Bandres-Ciga S, Carecchio M, Zorzi G, Nardocci N, Garavaglia B, Batla A, Bhatia KP, Pittman AM, Hardy J, Weissbach A, Klein C, Gasser T, Lohmann E, Wood NW.

Hum Mol Genet. 2015 Sep 15


open Pubmed abstract

Long-term disease progression in spinocerebellar ataxia types 1, 2, 3, and 6: A longitudinal cohort study

Jacobi H, du Montcel ST, Bauer P, Giunti P, Cook A, Labrum R, Parkinson MH, Durr A, Brice A, Charles P, Marelli C, Mariotti C, Nanetti L, Panzeri M, Rakowicz M, Sulek A, Sobanska A, Schmitz-Hübsch T, Schöls L, Hengel H, Baliko L, Melegh B, Filla A, Antenora A, Infante J, Berciano J, van de Warrenburg BP, Timmann D, Szymanski S, Boesch S, Kang JS, Pandolfo M, Schulz JB, Molho S, Diallo A, Klockgether T.

Lancet Neurol. 2015 Nov;14(11):1101-8. doi: 10.1016/S1474-4422(15)00202-1. Epub 2015 Sep 13.


open Pubmed abstract

Lack of enzyme activity in GBA2 mutants associated with hereditary spastic paraplegia/cerebellar ataxia (SPG46)

Sultana S, Reichbauer J, Schüle R, Mochel F, Synofzik M, van der Spoel AC.

Biochem Biophys Res Commun. 2015 Sep 11;465(1):35-40. doi: 10.1016/j.bbrc.2015.07.112. Epub 2015 Jul 26.


open Pubmed abstract

Neurodegeneration: Amyloid-β pathology induced in humans

Jucker M, Walker LC.

Nature. 2015 Sep 10;525(7568):193-4. doi: 10.1038/525193a. No abstract available.


open Pubmed abstract

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes.

Rannikko EH, Weber SS, Kahle PJ.

BMC Neurosci. 2015 Sep 7;16:57. doi: 10.1186/s12868-015-0192-0.


open PubMed abstract

Contribution of the non-effector members of the HrpL regulon, iaaL and matE, to the virulence of Pseudomonas syringae pv. tomato DC3000 in tomato plants

Castillo-Lizardo MG, Aragón IM, Carvajal V, Matas IM, Pérez-Bueno ML, Gallegos MT, Barón M, Ramos C.

BMC Microbiol. 2015 Aug 19;15:165. doi: 10.1186/s12866-015-0503-8.


open Pubmed abstract