Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease

Zou C, Shi Y, Ohli J, Schüller U, Dorostkar MM, Herms J.

Acta Neuropathol. 2016 Feb;131(2):235-46. doi: 10.1007/s00401-015-1527-8. Epub 2016 Jan 2.


open Pubmed abstract

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD

Edbauer D, Haass C.

Curr Opin Neurobiol. 2016 Feb;36:99-106. doi: 10.1016/j.conb.2015.10.009. Epub 2015 Nov 8. Review.


open Pubmed abstract

Loss of DJ-impairs antioxidant response by altered glutamine and serine metabolism

Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, d'Herouel AF, Dong X, Weindl D, Stautner C, Nonnenmacher Y, Michelucci A, Popp O, Giesert F, Schildknecht S, Krämer L, Schneider JG, Woitalla D, Wurst W, Skupin A, Weisenhorn DM, Krüger R, Leist M, Hiller K.

Neurobiol Dis. 2016 May;89:112-25. doi: 10.1016/j.nbd.2016.01.019. Epub 2016 Feb 1.


open Pubmed Abstract

Mechanisms of Alzheimer’s disease: Neuronal hyperactivity and hypoactivity as new therapeutic targets

Busche MA, Staufenbiel M, Willem M, Haass C, Förstl H.

Nervenarzt. 2016 Jan 19. [Epub ahead of print] German.


open Pubmed abstract

Creatine for neuroprotection in neurodegenerative disease: end of story?

Bender A, Klopstock T.

Amino Acids. 2016 Jan 9. [Epub ahead of print]


open Pubmed abstract

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S.

Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23


open Pubmed abstract

Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases

Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.

J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16.


open Pubmed abstract

Interaction of α-synuclein with biomembranes in Parkinson's disease - Role of cardiolipin

Ghio S, Kamp F, Cauchi R, Giese A, Vassallo N.

Prog Lipid Res. 2016 Jan;61:73-82. doi: 10.1016/j.plipres.2015.10.005. Epub 2015 Dec 15. Review.


open Pubmed abstract

DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

Halder R, Hennion M, Vidal RO, Shomroni O, Rahman RU, Rajput A, Centeno TP, van Bebber F, Capece V, Vizcaino JC, Schuetz AL, Burkhardt S, Benito E, Sala MN, Javan SB, Haass C, Schmid B, Fischer A, Bonn S.

Nat Neurosci. 2016 Jan;19(1):102-10. doi: 10.1038/nn.4194. Epub 2015 Dec 14.


open pubmed abstract

The phenotypic spectrum of progressive supranuclear palsy: A retrospective multicenter study of 100 definite cases

Respondek G, Stamelou M, Kurz C, Ferguson LW, Rajput A, Chiu WZ, van Swieten JC, Troakes C, Al Sarraj S, Gelpi E, Gaig C, Tolosa E, Oertel WH, Giese A, Roeber S, Arzberger T, Wagenpfeil S, Höglinger GU; Movement Disorder Society-endorsed PSP Study Group.

Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S34-6. doi: 10.1016/j.parkreldis.2015.09.041. Epub 2015 Sep 25.


open Pubmed Abstract

Three novel presenilin 1 mutations marking the wide spectrum of age at onset and clinical patterns in familial Alzheimer’s disease

Roeber S, Müller-Sarnowski F, Kress J, Edbauer D, Kuhlmann T, Tüttelmann F, Schindler C, Winter P, Arzberger T, Müller U, Danek A, Kretzschmar HA.

J Neural Transm (Vienna). 2015 Dec;122(12):1715-9. doi: 10.1007/s00702-015-1450-0. Epub 2015 Sep 8.


open Pubmed abstract

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

Saftig P, Lichtenthaler SF.

Prog Neurobiol. 2015 Dec;135:1-20. doi: 10.1016/j.pneurobio.2015.10.003. Epub 2015 Oct 29. Review.


open Pubmed abstract

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.

Mackenzie IR, Frick P, Grässer FA, Gendron TF, Petrucelli L, Cashman NR, Edbauer D, Kremmer E, Prudlo J, Troost D, Neumann M.

Acta Neuropathol. 2015 Dec;130(6):845-61. doi: 10.1007/s00401-015-1476-2. Epub 2015 Sep 15.


open Pubmed abstract

Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72

van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Boylan KB, Dickson DW, Rademakers R.

Acta Neuropathol. 2015 Dec;130(6):863-76. doi: 10.1007/s00401-015-1480-6. Epub 2015 Oct 5.


open Pubmed abstract

From a single nucleotide polymorphism to tau pathology: Appoptosin is the missing link

Respondek G, Höglinger GU, Stamelou M.

Mov Disord. 2015 Dec;30(14):1871-2. doi: 10.1002/mds.26464. Epub 2015 Nov 14. Review. No abstract available.


open Pubmed abstract

Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors

Garrett L, Zhang J, Zimprich A, Niedermeier KM, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Vogt Weisenhorn D, Wurst W, Hölter SM.

Front Behav Neurosci. 2015 Nov 12;9:302. doi: 10.3389/fnbeh.2015.00302. eCollection 2015.


open Pubmed abstract

Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons

Beck K, Ehmann N, Andlauer TF, Ljaschenko D, Strecker K, Fischer M, Kittel RJ, Raabe T.

Dis Model Mech. 2015 Nov;8(11):1389-400. doi: 10.1242/dmm.021246. Epub 2015 Sep 3.


open Pubmed abstract

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.

Gendron TF, van Blitterswijk M, Bieniek KF, Daughrity LM, Jiang J, Rush BK, Pedraza O, Lucas JA, Murray ME, Desaro P, Robertson A, Overstreet K, Thomas CS, Crook JE, Castanedes-Casey M, Rousseau L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Graff-Radford NR, Rademakers R, Lagier-Tourenne C, Edbauer D, Cleveland DW, Dickson DW, Petrucelli L, Boylan KB.

Acta Neuropathol. 2015 Oct;130(4):559-73. doi: 10.1007/s00401-015-1474-4. Epub 2015 Sep 8.


open Pubmed abstract

Label-free quantitative proteomics of mouse cerebrospinal fluid detects β-site APP cleaving enzyme (BACE1) protease substrates in vivo.

Dislich B, Wohlrab F, Bachhuber T, Müller SA, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF.

Mol Cell Proteomics. 2015 Oct;14(10):2550-63. doi: 10.1074/mcp.M114.041533. Epub 2015 Jul 2.


open PubMed abstract

Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse

Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W, Prakash N.

J Neurosci. 2015 Sep 30;35(39):13385-401. doi: 10.1523/JNEUROSCI.1722-15.2015.


open Pubmed abstract

Fingolimod induces neuroprotective factors in human astrocytes

Hoffmann FS, Hofereiter J, Rübsamen H, Melms J, Schwarz S, Faber H, Weber P, Pütz B, Loleit V, Weber F, Hohlfeld R, Meinl E, Krumbholz M.

J Neuroinflammation. 2015 Sep 30;12:184. doi: 10.1186/s12974-015-0393-6.


open Pubmed abstract

A new dopaminergic nigro-olfactory projection

Höglinger GU, Alvarez-Fischer D, Arias-Carrión O, Djufri M, Windolph A, Keber U, Borta A, Ries V, Schwarting RK, Scheller D, Oertel WH.

Acta Neuropathol. 2015 Sep;130(3):333-48. doi: 10.1007/s00401-015-1451-y. Epub 2015 Jun 14.


open Pubmed Abstract

Early Neurodegeneration in the Brain of a Child Without Functional PKR-like Endoplasmic Reticulum Kinase

Bruch J, Kurz C, Vasiljevic A, Nicolino M, Arzberger T, Höglinger GU.

J Neuropathol Exp Neurol. 2015 Aug;74(8):850-7. doi: 10.1097/NEN.0000000000000224.


open Pubmed abstract

Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy

Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick JA.

Hum Gene Ther Methods. 2015 Aug;26(4):107-22. doi: 10.1089/hgtb.2014.152. Epub 2015 Jul 29.


open Pucmed abstract

Correlation of two-photon in vivo imaging and FIB/SEM microscopy

Blazquez-Llorca L, Hummel E, Zimmerman H, Zou C, Burgold S, Rietdorf J, Herms J.

J Microsc. 2015 Aug;259(2):129-36. doi: 10.1111/jmi.12231. Epub 2015 Mar 18.

PMID: 25786682


open Pubmed Abstract