Zebrafish Models

Dr. Bettina Schmid


the complete list of publications is found here.

Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid. Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. Molecular Neurodegeneration. 2017 Jan 13; 12:1-11. doi: 10.1186/s13024-016-0146-8
Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid. Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. PLoS ONE. 2015 Mar 17; 10 doi: 10.1371/journal.pone.0118956
Alexander Hruscha, Bettina Schmid. Generation of zebrafish models by CRISPR/Cas9 genome editing 2014.
Alexander Hruscha, Peter Krawitz, Alexandra Rechenberg, Verena Heinrich, Jochen Hecht, Christian Haass, Bettina Schmid. Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development (Cambridge). 2013 Dec 14; 140:4982-4987. doi: 10.1242/dev.099085
Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proc Natl Acad Sci U S A. 2013 Mar 26; 110:4986-91. doi: 10.1073/pnas.1218311110
Sebastian Hogl, Frauke Van Bebber, Bastian Dislich, Peer-Hendrik Kuhn, Christian Haass, Bettina Schmid, Stefan F. Lichtenthaler. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 2013 Apr 30; 13:1519-1527. doi: 10.1002/pmic.201200582
Plucińska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T.. In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. Journal of Neuroscience. 2012 Nov 13; 32:16203-16212. doi: 10.1523/JNEUROSCI.1327-12.2012
Mareike E. Fett, Anna Pilsl, Dominik Paquet, Frauke van Bebber, Christian Haass, JöRg Tatzelt, Bettina Schmid, Konstanze F. Winklhofer. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE. 2010 Aug 19; 5 doi: 10.1371/journal.pone.0011783
Dominik Paquet, Ratan Bhat, Astrid Sydow, Eva-Maria Mandelkow, Stefan Berg, Sven Hellberg, Johanna Fälting, Martin Distel, Reinhard W. Köster, Bettina Schmid, Christian Haass. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. Journal of Clinical Investigation. 2009 Apr 30; 119:1382-1395. doi: 10.1172/JCI37537
Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. J Biol Chem. 2008 Jan 18; 283:1744-53.
Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. J Biol Chem. 2005 Nov 25; 280:39515-23.

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