Camin Dean
Synaptic Dysfunction
Dr. Camin Dean
Group Leader
Charitéplatz 1
intern: Hufelandweg 14
10117  Berlin
 +49 30 450-539708


The full list of publications is found here.

Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, Wang YT, Fischer A, Dean C. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2020 Jan 04; 363:6422. doi: 10.1126/science.aav1483
Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF. Membrane binding, internalization, and sorting of alpha-synuclein in the cell. Acta Neuropathol Commun. 2018 Aug 14; 6:79. doi: 10.1186/s40478-018-0578-1
Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer. RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment. Cell Reports. 2018 Apr 09; 23:546-554. doi: 10.1016/j.celrep.2018.03.059
Bharat V, Siebrecht M, Burk K, Ahmed S, Reissner C, Kohansal-Nodehi M, Steubler V, Zweckstetter M, Ting JT, Dean C. Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of synaptotagmin-4. Cell Rep. 2017 Nov 21; 21:2118-2133. doi: 10.1016/j.celrep.2017.10.084
Benito, Ramachandran, Schroeder, Schmidt, Urbanke, Burkhardt, Capece, Dean, Fischer. The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice. Translational psychiatry. 2017 Sep 25; 7:e1239. doi: 10.1038/tp.2017.202
Hurtado-Zavala JI, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, Stahlberg MA, Wagener RJ, Anderson K, Drenan RM, Lester HA, Miwa JM, Staiger JF, Fischer A, Dean C. TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nat Commun. 2017 Jul 19; 19:8:15878. doi: 10.1038/ncomms15878
Katja Burk, John D. Murdoch, Siona Freytag, Melanie Koenig, Vinita Bharat, Ronja Markworth, Susanne Burkhardt, Andre Fischer, Camin Dean. EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons. Scientific Reports. 2017 Nov 30; 7 doi: 10.1038/s41598-017-02202-4
Burk K, Ramachandran B, Ahmed S, Hurtado-Zavala JI, Awasthi A, Benito E, Faram R, Ahmad H, Swaminathan A, McIlhinney J, Fischer A, Perestenko P, Dean C. Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6. Cereb Cortex. 2017 Feb 03; :1-18. doi: 10.1093/cercor/bhx009
Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017 Jan 01; 149:149-170. doi: 10.1085/jgp.201611607
Eva Benito, Hendrik Urbanke, Binu Ramachandran, Jonas Barth, Rashi Halder, Ankit Awasthi, Gaurav Jain, Vincenzo Capece, Susanne Burkhardt, Magdalena Navarro-Sala, Sankari Nagarajan, Anna-Lena Schötz, Steven A. Johnsen, Stefan Bonn, Reinhardt Löhrmann, Camin Dean, André Fischer. HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation. 2014 Dec 31; 125:3572-3584. doi: 10.1172/JCI79942
Ramachandran B, Ahmed S, Dean C. Long-term depression is differentially expressed in distinct lamina of hippocampal CA1 dendrites. Front Cellular Neurosci. 2015 Feb 05; 9:23. doi: 10.3389/fncel.2015.00023
Dean C, Liu H, Staudt T, Stahlberg MA, Vingill S, Bückers J, Kamin D, Engelhardt J, Jackson MB, Hell SW, Chapman ER. Distinct subsets of syt-IV/ BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity. J Neurosci. 2012 Apr 18; 32:5398-5413. doi: 10.1523/JNEUROSCI.4515-11.2012
Dean C, Dunning FM, Liu H, Bomba-Warczak E, Martens H, Bharat V, Ahmed S, Chapman ER. Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen. Mol Biol Cell. 2012 May 01; 23:1715-27. doi: 10.1091/mbc.E11-08-0707
Dean C, Liu H, Dunning FM, Chang PY, Jackson, MB, Chapman, ER. Synaptotagmin-IV modulates synaptic function and LTP by regulating BDNF release. Nature Neurosci. 0009 Jan 01; 12:767-76. doi: 10.1038/nn.2315
Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nature Neurosci. 0003 Jul 01; 6:708-16. doi: 10.1038/nn1074


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