Caghan Kizil
Mechanisms of induced plasticity of the vertebrate brain
Dr. Caghan Kizil
Group Leader
Tatzberg 41
01307  Dresden
 +49 351 210 463-603


The complete list of publications is found here.

Bhattarai, P., Cosacak, M.I., Mashkaryan, V., Demir, S., Popova, S., Govindarajan, N., Brandt, K., Zhang, Y., Chang, W., Ampatzis, K., Kizil C. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain. PLoS Biol. 2020 Jan 06; 18:e3000585. doi: 10.1371/journal.pbio.3000585
Celikkaya H, Cosacak MI, Papadimitriou C, Popova S, Bhattarai P, Biswas SN, et al. GATA3 Promotes the Neural Progenitor State but Not Neurogenesis in 3D Traumatic Injury Model of Primary Human Cortical Astrocytes. Front Cell Neurosci. 2019 Jan 01; 13:23. doi: 10.3389/fncel.2019.00023
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Hannes C.A. Drexler, Sascha Menninger, Gunther Zischinsky, Jan Eickhoff, Claudia Fröb, Prabesh Bhattarai, Guruchandar Arulmozhivarman, Lara Marrone, Antje Janosch, Kenjiro Adachi, Martin Stehling, Eric N. Anderson, Masin Abo-Rady, Marc Bickle, Udai Bhan Pandey, Michell M. Reimer, Caghan Kizil, Hans R. Schöler, Peter Nussbaumer, Bert Klebl, Jared L. Sterneckert. Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo. Stem Cell Reports. 2019 Mar 04; 12:502-517. doi: 10.1016/j.stemcr.2019.01.015
Cosacak MI, Bhattarai P, Reinhardt S, Petzold A, Dahl A, Zhang Y, et al. Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Rep. 2019 Jan 01; 27:1307-18 e3. doi: 10.1016/j.celrep.2019.03.090
Kizil C. Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain. Current Pathobiology Reports. 2018 Jan 01; 6:71-7. doi: 10.1007/s40139-018-0158-x
Christos Papadimitriou, Hilal Celikkaya, Mehmet I. Cosacak, Violeta Mashkaryan, Laura Bray, Prabesh Bhattarai, Kerstin Brandt, Heike Hollak, Xin Chen, Shuijin He, Christopher L. Antos, Weilin Lin, Alvin Kuriakose Thomas, Andreas Dahl, Thomas Kurth, Jens Friedrichs, Yixin Zhang, Uwe Freudenberg, Carsten Werner, Caghan Kizil. 3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity. Developmental Cell. 2018 Jul 01; 46:85-101.e8. doi: 10.1016/j.devcel.2018.06.005
Kizil C, Bhattarai P. Is Alzheimer’s also a stem cell disease? – The zebrafish perspective. Front Cell Dev Biol. 2018 Jan 01; 6:159. doi: 10.3389/fcell.2018.00159
Bhattarai P, Thomas AK, Zhang Y, Kizil C. The effects of ageing on Amyloid-42-induced neurodegeneration and regeneration in adult zebrafish brain. Neurogenesis. 2017 Jan 01; 4:e1322666.
Mehmet I. Cosacak, Prabesh Bhattarai, Ledio Bocova, Tim Dzewas, Violeta Mashkaryan, Christos Papadimitriou, Kerstin Brandt, Heike Hollak, Christopher L. Antos, Caghan Kizil. Human TAU P301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain. Scientific Reports. 2017 Nov 30; 7 doi: 10.1038/s41598-017-13311-5
Prabesh Bhattarai, Alvin Kuriakose Thomas, Mehmet Ilyas Cosacak, Christos Papadimitriou, Violeta Mashkaryan, Cynthia Froc, Susanne Reinhardt, Thomas Kurth, Andreas Dahl, Yixin Zhang, Caghan Kizil. IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain. Cell Reports. 2016 Oct 17; 17:941-948. doi: 10.1016/j.celrep.2016.09.075
Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand M. The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Development. 2012 Jan 01; 7:27.
Kizil C, Kaslin J, Kroehne V, Brand M. Adult neurogenesis and brain regeneration in zebrafish. Developmental Neurobiology. 2012 Jan 01; 72:429-461.
Kizil C, Kyritsis N, Dudczig S, Kroehne V, Freudenreich F, Kaslin J, Brand M. Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Developmental Cell. 2012 Jan 01; 23:1230-1237.
Kizil C, Otto GW, Geisler R, Nüsslein-Volhard C, Antos CL. Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Developmental Biology. 2009 Jan 01; 352:329-40.
Verdugo CD, Myren-Svelstad S, Aydin E, van Hoeymissen E, Deneubourg C, Vanderhaeghe S, et al. Glia-neuron interactions underlie state transitions to generalized seizures. Nat Commun. 2019 Jan 01; in press


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