Michael Heneka
Neuroinflammation
Prof. Dr. Michael T. Heneka
Cooperation Unit Leader
Director of the Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn
c/o Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie
Venusberg-Campus 1, Gebäude 82
53127 Bonn

michael.heneka@dzne.de
 +49 228 287-13091

Publications

The complete list of publications is found here.

Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. EMBO J. 2019 Sep 02; 38:e101064. doi: 10.15252/embj.2018101064
Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock D, Geyer M, Walter J, Latz E & Heneka MT. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease. Nature. 2017 Dec 20; 552:355-361. doi: 10.1038/nature25158
Hannah Scheiblich, Anna Schlütter, Douglas T. Golenbock, Eicke Latz, Pilar Martinez-Martinez, Michael T. Heneka. Activation of the NLRP3 inflammasome in microglia: the role of ceramide. Journal of Neurochemistry. 2017 Nov 30; 143:534-550. doi: 10.1111/jnc.14225
Heela Sarlus, Michael T. Heneka. Microglia in Alzheimer's disease. Journal of Clinical Investigation. 2017 Aug 31; 127:3240-3249. doi: 10.1172/JCI90606
Teodora Stella Wijasa, Marc Sylvester, Nahal Brocke-Ahmadinejad, Markus P. Kummer, Frederic Brosseron, Volkmar Gieselmann, Michael T. Heneka. Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags. Journal of Neuroscience Methods. 2017 Oct 31; 291:95-100. doi: 10.1016/j.jneumeth.2017.08.005
Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, Santarelli F, Gieselmann V, Klockgether T, Brosseron F, Heneka MT. Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease. J Neurochem. 2019 Sep 14; doi: 10.1111/jnc.14870
Frederic Brosseron, Andreas Traschütz, Catherine N. Widmann, Markus P. Kummer, Pawel Tacik, Francesco Santarelli, Frank Jessen, Michael T. Heneka. Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease. Alzheimer's Research and Therapy. 2018 Feb 25; 10 doi: 10.1186/s13195-018-0353-3
Róisín M. McManus, Michael T. Heneka. Role of neuroinflammation in neurodegeneration: New insights. Alzheimer's Research and Therapy. 2017 Mar 03; 9 doi: 10.1186/s13195-017-0241-2
Tejera D, Heneka MT. Microglia in Alzheimer’s disease: the good, the bad and the ugly. Curr Alzheimer Res. 2016 Jan 01; 13:370-80. doi: 10.2174/1567205013666151116125012
Michael T. Heneka, Anne Fink, Gabriele Doblhammer. Effect of pioglitazone medication on the incidence of dementia. Annals of Neurology. 2014 Dec 31; 78:284-294. doi: 10.1002/ana.24439
Michael T Heneka, Monica J Carson, Joseph El Khoury, Gary E Landreth, Frederic Brosseron, Douglas L Feinstein, Andreas H Jacobs, Tony Wyss-Coray, Javier Vitorica, Richard M Ransohoff, Karl Herrup, Sally A Frautschy, Bente Finsen, Guy C Brown, Alexei Verkhratsky, Koji Yamanaka, Jari Koistinaho, Eicke Latz, Annett Halle, Gabor C Petzold, Terrence Town, Dave Morgan, Mari L Shinohara, V Hugh Perry, Clive Holmes, Nicolas G Bazan, David J Brooks, Stéphane Hunot, Bertrand Joseph, Nikolaus Deigendesch, Olga Garaschuk, Erik Boddeke, Charles A Dinarello, John C Breitner, Greg M Cole, Douglas T Golenbock, Markus P Kummer. Neuroinflammation in Alzheimer's disease. The Lancet Neurology. 2014 Dec 31; 14:388-405. doi: 10.1016/S1474-4422(15)70016-5
Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer’s disease. Nat Immunol. 2015 Jan 01; 16:229-36. doi: 10.1038/ni.3102
Michael T. Heneka, Markus P. Kummer, Eicke Latz. Innate immune activation in neurodegenerative disease. Nature Reviews Immunology. 2013 Dec 31; 14:463-477. doi: 10.1038/nri3705
Michael T. Heneka, Markus P. Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng, Ellen Gelpi, Annett Halle, Martin Korte, Eicke Latz, Douglas T. Golenbock. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013 Feb 06; 494:674-678.
Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT. Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron. 2011 Sep 08; 71:833-44. doi: 10.1016/j.neuron.2011.07.001
Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, Kummer MP. Locus ceruleus controls Alzheimer’s disease pathology by modulatin microglia functions through norepinephrine. Proc Natl Acad Sci U S A. 2010 Mar 30; 107:6058-63. doi: 10.1073/pnas.0909586107
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci USA. 2006 Jan 10; 103:443-8. doi: 10.1073/pnas.0503839103

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