Prof. Dr. Regina Fluhrer
Signal Peptide Peptidases a Models for γ-Secretase
Prof. Dr. Regina Fluhrer
Cooperation Unit Leader
Prof. Fluhrer is group leader at the Biomedical Center Munich at the LMU Munich
Feodor-Lynen-Str. 17
81377 München

regina.fluhrer@dzne.de
 +49 89 4400-46505

Publications

The complete list of publications is found here.

Fluhrer R. Intramembrane Proteases in Neurodegenerative Diseases. Open Access Government. 2019 Jul 01; ISSN 2516-3817:162-164.
Alkmini A Papadopoulou, Stephan A Müller, Torben Mentrup, Merav D Shmueli, Johannes Niemeyer, Martina Haug-Kröper, Julia von Blume, Artur Mayerhofer, Regina Feederle, Bernd Schröder, Stefan F Lichtenthaler, Regina Fluhrer. Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Reports. 2018 Dec 31; doi: 10.15252/embr.201846451
Johannes Niemeyer, Torben Mentrup, Ronny Heidasch, Stephan A Müller, Uddipta Biswas, Rieke Meyer, Alkmini A Papadopoulou, Verena Dederer, Martina Haug-Kröper, Vivian Adamski, Renate Lüllmann-Rauch, Martin Bergmann, Artur Mayerhofer, Paul Saftig, Gunther Wennemuth, Rolf Jessberger, Regina Fluhrer, Stefan F Lichtenthaler, Marius K Lemberg, Bernd Schröder. The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Reports. 2018 Dec 31; doi: 10.15252/embr.201846449
Lichtenthaler SF, Lemberg MK, Fluhrer R. Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments. EMBO J. 2018 Aug 01; 37 doi: 10.15252/embj.201899456
Torben Mentrup, Ann-Christine Loock, Regina Fluhrer, Bernd Schröder. Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?. Biochimica et Biophysica Acta - Molecular Cell Research. 2017 Oct 31; 1864:2169-2182. doi: 10.1016/j.bbamcr.2017.06.007
Torben Mentrup, Regina Fluhrer, Bernd Schröder. Latest emerging functions of SPP/SPPL intramembrane proteases. European Journal of Cell Biology. 2017 Jul 31; 96:372-382. doi: 10.1016/j.ejcb.2017.03.002
Daniel Fleck, Matthias Voss, Ben Brankatschk, Camilla Giudici, Heike Hampel, Benjamin Schwenk, Dieter Edbauer, Akio Fukumori, Harald Steiner, Elisabeth Kremmer, Martina Haug-Kröper, Moritz J. Rossner, Regina Fluhrer, Michael Willem, Christian Haass. Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases. Journal of Biological Chemistry. 2015 Dec 31; 291:318-333. doi: 10.1074/jbc.M115.697995
Peer-Hendrik Kuhn, Matthias Voss, Martina Haug-Kröper, Bernd Schröder, Ute Scheperse, Stefan Bräse, Christian Haass, Stefan F. Lichtenthaler, Regina Fluhrer. Secretome analysis identifies novel signal peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple golgi glycosylation pathways. Molecular and Cellular Proteomics. 2014 Dec 31; 14:1584-1598. doi: 10.1074/mcp.M115.048298
Frits Kamp, Edith Winkler, Johannes Trambauer, Amelie Ebke, Regina Fluhrer, Harald Steiner. Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process. Biophysical Journal. 2015 Mar 09; 108:1229-1237. doi: 10.1016/j.bpj.2014.12.045
Matthias Voss, Ulrike Künzel, Fabian Higel, Peer-Hendrik Kuhn, Alessio Colombo, Akio Fukumori, Martina Haug-Kröper, Bärbel Klier, Gudula Grammer, Andreas Seidl, Bernd Schröder, Reinhard Obst, Harald Steiner, Stefan F. Lichtenthaler, Christian Haass, Regina Fluhrer. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO Journal. 2013 Dec 31; 33:2890-2905. doi: 10.15252/embj.201488375
Matthias Voss, Akio Fukumori, Peer-Hendrik Kuhn, Ulrike Künzel, Bärbel Klier, Gudula Grammer, Martina Haug-Kröper, Elisabeth Kremmer, Stefan F. Lichtenthaler, Harald Steiner, Bernd Schröder, Christian Haass, Regina Fluhrer. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). Journal of Biological Chemistry. 2012 Dec 20; 287:43401-43409. doi: 10.1074/jbc.M112.371369
Regina Fluhrer, Lucas Martin, Bärbel Klier, Martina Haug-Kröper, Gudula Grammer, Brigitte Nuscher, Christian Haass. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). Journal of Biological Chemistry. 2012 Feb 09; 287:5156-5163. doi: 10.1074/jbc.M111.328104
Regina Fluhrer, Frits Kamp, Gudula Grammer, Brigitte Nuscher, Harald Steiner, Klaus Beyer, Christian Haass. The Nicastrin ectodomain adopts a highly thermostable structure. Biological Chemistry. 2011 Oct 31; 392:995-1001. doi: 10.1515/BC.2011.169
Martin L, Fluhrer R, Haass C. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. J Biol Chem. 2009 Feb 27; 284:5662-70. doi: 10.1074/jbc.M807485200
Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C. Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. J Biol Chem. 2008 Oct 31; 283:30121-8. doi: 10.1074/jbc.M806092200

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