Mitochondria and Inflammation in Neurodegenerative Diseases
Jun.-Prof. Dr. Michela Deleidi
Group Leader
Otfried-Müller-Str. 23
72076 Tübingen

michela.deleidi@dzne.de
 +49 7071 9254-105

Research areas/focus

Research in our laboratory concentrates on the molecular mechanisms of neurodegeneration, with a special emphasis on the role of inflammation in Parkinson's disease. Neuroinflammatory genes have been associated with several neurodegenerative diseases, including Parkinson's disease. Our aim is to understand, at the molecular level, how disease-associated genetic variants affect immune cell metabolism, and how immune responses within or outside the brain contribute to neurodegeneration.

Another line of research concentrates on the role of GBA1 mutations in Parkinson's disease. GBA1 mutations represent the most common risk factor for Parkinson’s disease identified to date. Ongoing research in our laboratory focuses on the mechanistic pathways involved in GBA1-linked neurodegeneration, with a particular interest in mitochondrial function and autophagy. In parallel, the laboratory is exploring novel strategies to increase glucocerebrosidase activity.

We do that by combining patient neurons derived from induced pluripotent stem cells (iPSCs) and CRISPR-Cas9 genome editing techniques.

Key Publications

Vikram Khurana, Jian Peng, Chee Yeun Chung, Pavan K. Auluck, Saranna Fanning, Daniel F. Tardiff, Theresa Bartels, Martina Koeva, Stephen W. Eichhorn, Hadar Benyamini, Yali Lou, Andy Nutter-Upham, Valeriya Baru, Yelena Freyzon, Nurcan Tuncbag, Michael Costanzo, Bryan-Joseph San Luis, David C. Schöndorf, M. Inmaculada Barrasa, Sepehr Ehsani, Neville Sanjana, Quan Zhong, Thomas Gasser, David P. Bartel, Marc Vidal, Michela Deleidi, Charles Boone, Ernest Fraenkel, Bonnie Berger, Susan Lindquist. Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. Cell Systems. 2017 Feb 21; 4:157-170.e14. doi: 10.1016/j.cels.2016.12.011
Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson's Disease. Cell Stem Cell. 2015 Mar 05; 16:269-74. doi: 10.1016/j.stem.2015.01.018
David C. Schöndorf, Massimo Aureli, Fiona E. McAllister, Christopher J. Hindley, Florian Mayer, Benjamin Schmid, S. Pablo Sardi, Manuela Valsecchi, Susanna Hoffmann, Lukas Kristoffer Schwarz, Ulrike Hedrich, Daniela Berg, Lamya S. Shihabuddin, Jing Hu, Jan Pruszak, Steven P. Gygi, Sandro Sonnino, Thomas Gasser, Michela Deleidi. IPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nature Communications. 2014 Jun 05; 5 doi: 10.1038/ncomms5028
Deleidi M, Cooper O, Hargus G, Hallett PJ, Osborn T, Isacson O. Development of histocompatible primate induced pluripotent stem cells for neural transplantation. Stem Cells. 2011 Jan 01; 29:1052-63. doi: 10.1002/stem.662
Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O. The Toll-like receptor-3 agonist poly(I:C) triggers nigrostriatal dopaminergic degeneration. J Neurosci. 2010 Jan 01; 30:16091-101. doi: 10.1523/JNEUROSCI.2400-10.2010

Info-Hotline

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