Michela Deleidi
Mitochondria and Inflammation in Neurodegenerative Diseases
Jun.-Prof. Dr. Michela Deleidi
Group Leader
Otfried-Müller-Str. 23
72076  Tübingen

michela.deleidi@dzne.de
 +49 7071 9254-105

Publications

The complete list of publications is found here.

Ivanyuk D, Perez MJ, Panagiotakopoulou V, Di Napoli G, Brunetti D, Al-Shaana R, Kaeser S, Jucker M, Zeviani M, Viscomi C, Deleidi M. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids. In revision. ;
De Cicco S, Ivanyuk D, Yu C, Haq W, Panagiotakopoulou V, Arsic A, Schöndorf DC, Nikic I, Gasser T, Deleidi M. Interferon-gamma signaling synergizes with LRRK2 in human neurons and microglia. In revision. ;
Pascale Baden, Cong Yu, Michela Deleidi. Insights into GBA Parkinson's disease pathology and therapy with induced pluripotent stem cell model systems. Neurobiology of Disease. 2019 Jun 30; 127:1-12. doi: 10.1016/j.nbd.2019.01.023
Compagnoni GM, Kleiner G, Samarani M, Aureli M, Faustini G, Bellucci A, Ronchi D, Bordoni A, Garbellini M, Salani S, Fortunato F, Frattini E, Abati E, Bergamini C, Fato R, Tabano S, Miozzo M, Serratto G, Passafaro M, Deleidi M, Silipigni R, Nizzardo M, Bresolin N, Comi GP, Corti S, Quinzii CM, Di Fonzo A. Impaired autophagy and mitochondrial dysfunction in iPSC-derived dopaminergic neurons of Multiple System Atrophy. Stem Cell Rep. 2018 Nov 13; 11:1185-1198. doi: 10.1016/j.stemcr.2018.09.007
David C. Schöndorf, Dina Ivanyuk, Pascale Baden, Alvaro Sanchez-Martinez, Silvia De Cicco, Cong Yu, Ivana Giunta, Lukas K. Schwarz, Gabriele Di Napoli, Vasiliki Panagiotakopoulou, Sigrun Nestel, Marcus Keatinge, Jan Pruszak, Oliver Bandmann, Bernd Heimrich, Thomas Gasser, Alexander J. Whitworth, Michela Deleidi. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. Cell Reports. 2018 Jun 04; 23:2976-2988. doi: 10.1016/j.celrep.2018.05.009
Marrone L, Bus C, Schöndorf D, Fitzgerald F, Kübler M, Schmid B, Reinhardt P, Deleidi M, Levin T, Meixner A, Klink B, Glatza M, Gloeckner CJ, Gasser T, Sterneckert J. Generation of iPSCs stratified for a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease. PLoS One. 2018 Mar 04; 13:e0192497. doi: 10.1371/journal.pone.0192497
Straniero L, Soldà G, Rimoldi V, Samarani M, Goldwurm S, Di Fonzo A, Kruger R, Deleidi M, Aureli M, Duga S, Asselta R. The GBAP1 pseudogene acts as a competing endogenous RNA for the Parkinson-related gene GBA by sponging miR-22-3p. Sci Rep. 2017 Oct 05; 7:12702. doi: 10.1038/s41598-017-12973-5
Letizia Straniero, Valeria Rimoldi, Maura Samarani, Stefano Goldwurm, Alessio Di Fonzo, Rejko Krüger, Michela Deleidi, Massimo Aureli, Giulia Soldà, Stefano Duga, Rosanna Asselta. The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p. Scientific Reports. 2017 Nov 30; 7 doi: 10.1038/s41598-017-12973-5
Vikram Khurana, Jian Peng, Chee Yeun Chung, Pavan K. Auluck, Saranna Fanning, Daniel F. Tardiff, Theresa Bartels, Martina Koeva, Stephen W. Eichhorn, Hadar Benyamini, Yali Lou, Andy Nutter-Upham, Valeriya Baru, Yelena Freyzon, Nurcan Tuncbag, Michael Costanzo, Bryan-Joseph San Luis, David C. Schöndorf, M. Inmaculada Barrasa, Sepehr Ehsani, Neville Sanjana, Quan Zhong, Thomas Gasser, David P. Bartel, Marc Vidal, Michela Deleidi, Charles Boone, Ernest Fraenkel, Bonnie Berger, Susan Lindquist. Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. Cell Systems. 2017 Feb 21; 4:157-170.e14. doi: 10.1016/j.cels.2016.12.011
Michela Deleidi, Madeline Jäggle, Graziella Rubino. Immune ageing, dysmetabolism and inflammation in neurological diseases. Frontiers in Neuroscience. 2015 Apr 27; 9 doi: 10.3389/fnins.2015.00172
Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson's Disease. Cell Stem Cell. 2015 Mar 05; 16:269-74. doi: 10.1016/j.stem.2015.01.018
David C. Schöndorf, Massimo Aureli, Fiona E. McAllister, Christopher J. Hindley, Florian Mayer, Benjamin Schmid, S. Pablo Sardi, Manuela Valsecchi, Susanna Hoffmann, Lukas Kristoffer Schwarz, Ulrike Hedrich, Daniela Berg, Lamya S. Shihabuddin, Jing Hu, Jan Pruszak, Steven P. Gygi, Sandro Sonnino, Thomas Gasser, Michela Deleidi. IPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nature Communications. 2014 Jun 05; 5 doi: 10.1038/ncomms5028

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