Melania Capasso
Immune Regulation
Dr. Melania Capasso
Group Leader
Venusberg-Campus 1/99
53127  Bonn
 +49 228 43302325


The complete list of publications is found here.


Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M, Haworth O. Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Rep. 2019 Apr 30; 27:1461-1471. doi: 10.1016/j.celrep.2019.04.014
Spear S, Candido JB, McDermott JR, Ghirelli C, Maniati E, Beers SA, Balkwill FR, Kocher HM, Capasso M. Discrepancies in the Tumor Microenvironment of Spontaneous and Orthotopic Murine Models of Pancreatic Cancer Uncover a New Immunostimulatory Phenotype for B Cells. Front Immunol. 2019 Mar 27; 10:542. doi: 10.3389/fimmu.2019.00542
Gabandé-Rodríguez E, Keane L, Capasso M. Microglial phagocytosis in aging and Alzheimer's disease. J Neurosci Res. 2019 Apr 03; doi: 10.1002/jnr.24419
Fu H, Jangani M, Parmar A, Wang G, Coe D, Spear S, Sandrock I, Capasso M, Coles M, Cornish G, Helmby H, Marelli-Berg FM. A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer. Front Immunol. 2019 Feb 25; 10:271. doi: 10.3389/fimmu.2019.00271
Arumugam P, Bhattacharya S, Chin-Aleong J, Capasso M, Kocher HM. Expression of polymeric immunoglobulin receptor and stromal activity in pancreatic ductal adenocarcinoma. Pancreatology. 2017 Mar 01; 17:295-302. doi: 10.1016/j.pan.2017.01.013
Montfort A, Pearce O, Maniati E, Vincent BG, Bixby L, …, Capasso M, et al. A Strong Bcell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases. Clin Cancer Res. 2017 Jan 01; 23:250-262. doi: 10.1158/1078-0432.CCR-16-0081
McClanahan F, Riches JC, Miller S, Day WP, Kotsiou E, Neuberg D, Croce CM, Capasso M, Gribben JG. Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model. Blood. 2015 Jan 01; 126:212-21.
Bartesaghi S, Graziano V, Galavotti S, Henriquez N, Betts J, Saxena J, Karlsson A, Martins LM, Capasso M, Nicotera P, Brandner S, De Laurenzi V, Salomoni P. Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. Proc Natl Acad Sci USA. ; 112:1059-1064. doi: 10.1073/pnas.1413165112
Hondares E, Brown MA, Musset B, Morgan D, Cherny VV,…, Capasso M. Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells. Proc Natl Acad Sci U S A. 2014 Jan 01; 111:18078-83. doi: 10.1073/pnas.1411390111
Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol. 2010 Jan 01; 11:265-72. doi: 10.1038/ni.1843
Morgan D, Capasso M, Musset B, Cherny VV, Ríos E, Dyer MJ, et al. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009 Jan 01; 106:18022-7. doi: 10.1073/pnas.0905565106
Russell LJ, Capasso M, Vater I, Akasaka T, Bernard OA, Calasanz MJ, et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood. 2009 Jan 01; 114:2688-98. doi: 10.1182/blood-2009-03-208397


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