Hemmen Sabir
Neonatal Neuroscience
Priv.-Doz. Dr. Hemmen Sabir
Group Leader
Venusberg-Campus 1
Gebäude 99
53127  Bonn

 +49 228 43302-624

Areas of investigation/research focus

The aim of our work is studying mechanisms of perinatal brain injury and establishing neuroprotective strategies. We use different methods as long-term neurofunctional outcome tests and cell-specific profiling.

The main focus is on:

  • mechanisms of inflammation-sensitized experimental hypoxic-ischemic brain injury with and without hypothermia
  • defining the role of microglia in our models of perinatal brain injury (hypoxia-ischemia, inflammation, prematurity)
  • establishing early biomarkers of adverse outcome in our models
  • establishing neuroprotective strategies

Key publications

Serdar M, Kempe K, Rizazad M, Herz J, Bendix I, Felderhoff-Müser U, Sabir H. Early Pro-inflammatory Microglia Activation After Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats. Front Cell Neurosci. 2019 May 24; 13:237. doi: 10.3389/fncel.2019.00237
Falck M, Osredkar D, Wood TR, Maes E, Flatebø T, Sabir H, Thoresen M. Neonatal Systemic Inflammation Induces Inflammatory Reactions and Brain Apoptosis in a Pathogen-Specific Manner. Neonatology. 2018 Jan 01; 113:212-220. doi: 10.1159/000481980
Sabir H, Osredkar D, Maes E, Wood T, Thoresen M. Xenon combined with therapeutic hypothermia is not neuroprotective after severe hypoxia-ischemia in neonatal rats. PLoS One. 2016 Jun 02; 11:e0156759. doi: 10.1371/journal.pone.0156759
Osredkar D, Thoresen M, Maes E, Flatebø T, Elstad M, Sabir H. Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury. Resuscitation. 2014 Apr 01; 85:567-72. doi: 10.1016/j.resuscitation.2013.12.006
Sabir H, Scull-Brown E, Liu X, Thoresen M. Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats. Stroke. 2012 Dec 01; 43:3364-70. doi: 10.1161/STROKEAHA.112.674481


Thursdays 1:30-4:30 pm

Patients +49 800-7799001

(free of charge)

Professionals +49 180-779900

(9 Cent/Min. German landline, mobile and out of Germany possibly more expensive)

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