Dementia prevention – mechanisms and clinical implementation
Prof. Dr. Agnes Flöel
Group Leader
Universitätsmedizin Greifswald, Klinik und Poliklinik für Neurologie,
Ferdinand-Sauerbruch-Straße
17475  Greifswald

agnes.floeel@dzne.de
 +49 3834 86-6815

The group is working on topics such as healthy aging, cognitive impairment in old age, post-stroke neurorehabilitation, and vascular and Alzheimer's dementia.

Learning processes are examined for their neuronal correlates in a healthy aging, neurodegeneratively altered or stroke-damaged brain (behavioral measurements, functional and structural MRI-based imaging, electrophysiologically determined long-term potentiation).

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Based on this, we develop interventional methods for learning improvement, especially in the area of ​​recovery of speech and motor skills after a stroke as well as in neurodegenerative diseases. These include pharmacological learning support (dopaminergic and serotonergic agents), electrical brain stimulation (transcranial magnetic stimulation, transcranial DC stimulation) and lifestyle interventions such as physical activity or dietary approaches. In this context, we also investigate the interaction of response to interventional procedures with genetic predisposition.

Clinical studies are performed in the area of ​​speech recovery and motor recovery as well as in patients with neurodegenerative diseases

Publications

Meinzer M, Lindenberg R, Phan MT, Ulm L, Volk C, Flöel A. Transcranial direct current stimulation in mild cognitive impairment: Behavioral effects and neural mechanisms. Alzheimers Dement. 2015 Sep 01; 11:1032-40. doi: 10.1016/j.jalz.2014.07.159
Meinzer M, Darkow R, Lindenberg R, Flöel A. Electrical stimulation of the motor cortex enhances treatment outcome in post-stroke aphasia. Brain. 2016 Apr 01; 139:1152-63. doi: 10.1093/brain/aww002
Antonenko D, Schubert F, Bohm F, Ittermann B, Aydin S, Hayek D, Grittner U, Flöel A. tDCS-Induced Modulation of GABA Levels and Resting-State Functional Connectivity in Older Adults. J Neurosci. 2017 Apr 12; 37:4065-4073. doi: 10.1523/JNEUROSCI.0079-17.2017
Ladenbauer J, Ladenbauer J, Külzow N, de Boor R, Avramova E, Grittner U, Flöel A. Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment. J Neurosci. 2017 Jul 26; 37:7111-7124. doi: 10.1523/JNEUROSCI.0260-17.2017
Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. 2018 Dec 03; 109:181-188. doi: 10.1016/j.cortex.2018.09.014

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