Clinical studies at the Bonn site
If you wish to support our research at the Bonn site by participating in a study, please review the following overview of all studies for which we are currently looking for volunteers:
DZNE studies
Healthy Volunteers / Controls
- 7T-TGA (high-resolution MRI imaging in TGA patients: a retrospective and prospective study)
- ALS-FTD Cognition (Attention and memory functions in amyotrophic lateral sclerosis and frontotemporal dementia)
- Neural correlates of aphantasia: assessments using functional magnetic resonance imaging.
- ApoE Navi (Influences of the APOE-ε4 genotype and other Alzheimer´s disease (AD) related genes on spatial navigation ability and its neural basis)
- DANCER (Establishment of a Recruitment Pool of Potential Study Participants, of Realtives and a Control Group for DZNE Studies)
- DANCER-FTD (Recruitment of Realtives and a Control Group for the DESCRIBE-FTD Study)
- DANCER-PSP (Recruitment of Realtives and a Control Group for the DESCRIBE-PSP Study)
- EnergI (Endurance training in old age)
Probands with movement disorders
- DESCRIBE (DZNE - Clinical Register Study of neurodegenerative Disorders)
- DESCRIBE-PSP (DZNE - Clinical Registry Study on Progressive Supranuclear Paresis (PSP))
- Eye and neurodegeneration
- NIO752 (Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of NIO752 in Progressive Supranuclear Palsy)
Probands with cognitive disorders
- ALS-FTD Cognition (Attention and memory functions in amyotrophic lateral sclerosis and frontotemporal dementia)
- DESCRIBE (DZNE - Clinical Register Study of neurodegenerative Disorders)
- DESCRIBE-FTD (DZNE - Clinical Registry Study on Frontotemporal Dementia (FTD))
- Eye and neurodegeneration
- Vorinostat_AD (A dose-finding study to address safety (and efficacy) of Vorinostat in Alzheimer‘s Disease)
Probands with ataxias / HSP
- ARCA (Autosomal-Recessive Cerebellar Ataxias)
- ESMI (European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative)
- Eye and neurodegeneration
- HSP-Net (Networking Project on Hereditary Spastic Paraplegia)
- SCA Registry (Registry for Spinocerebellar Ataxies (SCA))
- SPORTAX-NHS (Observational Study on Adult Onset Sporadic Ataxias)
Studies in cooperation with the DZNE
Projects in cooperation with the DZNE
ongoing studies (recruiting completed)
- ApoE Sleep (Influence of the Apolipoprotein-E Genotype on Brain Activity during Sleep and Wakefulness)
- Corona and cognition (The effects of restrictions caused by the coronavirus SARS-CoV-2 on cognitive health and dementia prevention)
- DELCODE (DZNE - Longitudinal Cognitive Impairment and Dementia study)
- DEMDAS (DZNE - Mechanisms of Dementia After Stroke Study)
- Functional Importance of the Noradrenaline System in connection with Memory Impairments and Alzheimer's Disease
- GENERATION HD1 (Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Patients With Manifest Huntington's Disease)
- IONIS-MAPTRX-CS1 (A placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of intrathecally administered ISIS 814907 in patients with mild Alzheimer’s disease)
- M-Star (placebo-controlled, parallel-group study to evaluate the efficacy and safety of BHV-3241 in subjects with multiple system atrophy)
- MiGAP (Markers in GBA-associated Parkinson's Disease – Early Detection, Progression, Mechanisms, Protection)
- PASADENA - A Placebo-controlled study to evaluate the efficacy of intravenous RO7046015 (PRX002) in patients with early Parkinson’s disease
completed studies
- BonSEP (Long-Term Cognitive and Cerebral Changes in Sepsis Survivors and their Predictors)
- GenHighfield (Study of the Influence of Apolipoprotein-E Polymorphisms on the Structure and Function of Hippocampus Formation, using EEG and Ultra-High-Field 7T MRI)
- StimMem (Effects of transcranial electrical brain stimulation on memory)