Scientific background

Proteolysis at or within the membrane is a fundamental cellular mechanism to control the function and abundance of membrane proteins, both at the cell surface and in organelles. This form of proteolysis is essential for cell homeostasis (e.g. quality control) and communication of cells with their environment (e.g. signal transduction), but also contributes to numerous disease conditions, such as inflammation, cancer and neurodegeneration. Several drugs targeting proteolysis at the membrane have advanced into clinical trials, for example in Alzheimer’s disease (targeting TREM2) and inflammation (e.g. gp130), but some drugs (e.g. BACE inhibitors) show side effects that need to be overcome before their clinical tests can continue.

The conference will focus on ectodomain shedding (ADAM, BACE, MMP proteases), intramembrane proteolysis (gamma-secretase, rhomboids, SPPL-proteases, S1P/S2P-proteases, signal-peptidase), protease “modulators” (such as tetraspanins and iRhoms) and inhibitors, substrate biology, proteolytic quality control as well as on therapeutic approaches.

Goals and participants

The overall goal of the meeting is to discuss outstanding new scientific findings and exciting new developments regarding the function, regulation and therapeutic potential of proteolysis at the membrane. The meeting covers basic and applied science as well as translation to patients and brings together around 120 young and established scientists from academia, pharma, biotech and medicine. The meeting is intended as the first of a series of meetings on this topic (to be held every other year) and provides a place for excellent new science and also for community building in the exciting field of proteolysis at the membrane.

Please find the preliminary program here

Registration

Please notice: At the moment we have more registrations than available places. You can still register, we have a waiting list.

Early registration until 31^th January 2024

After registering, you will receive a confirmation e-mail specifying the bank account to which the registration fee needs to be transferred. Once your fee is received, you are finally registered.

Early registration fee per person is 770 € and includes accommodation and meals. In case of cancellation of participation until 29^th February 2024, the registration fee is fully refundable. After 29^th February 2024 a refund of the registration fee is no longer possible.

Registration fee after 31^th January 2024 is 850 €.