The DZNE lecture series presents world-leading scientists from life science research, covering the diverse research areas at the DZNE including fundamental biology, translational, clinical, epidemiological and systems medicine research. The lectures aim to foster an exchange between disciplines and catalyze scientific interactions. Furthermore, the lecture series puts an emphasis on enabling students and postdocs to informally interact with the speaker, including via a dedicated Speaker's Lunch following each Lecture.
Tuesday, June 4th 2019, 12:00 pm
Modelling human brain developmental diseases using on-chip human brain organoids
Orly Reiner, Ph.D
Human brain folding has been implicated in neurodevelopmental disorders such as lissencephaly. Here, we will describe using our on-chip human brain organoid platform to study the appearance of surface folds during the in vitro development and self-organization. Our micro-fabricated devices support in situ imaging over a timescale of weeks. Lissencephalic (smooth brain) organoids display reduced convolutions, modified scaling and a reduced elastic modulus. We could also observe size reduction in microcephalic brain organoids. Our on-chip approach offers a means for studying the emergent properties of organoid development, with implications for the embryonic human brain.
For more Information:Orly Reiner's Lab
If you wish to meet the speaker, please contact Eva Mandelkow.
Deutsches Zentrum für Neurodegenerative Erkrankungen e. V.
Lecture hall (ground floor)
Venusberg Campus 1
12:00 pm - 13:00 pm