Publikationen
Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder.
Vassos E, Steinberg S, Cichon S, Breen G, Sigurdsson E, Andreassen OA, Djurovic S, Morken G, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Babadjanova G, Abramova LI, Mühleisen TW, Nöthen MM, Rietschel M, McGuffin P, Clair DS, Gustafsson O, Melle I, Pietiläinen OP, Ruggeri M, Tosato S, Werge T, Ophoff RA; GROUP Consortium, Rujescu D, Børglum AD, Mors O, Mortensen PB, Demontis D, Hollegaard MV, van Winkel R, Kenis G, De Hert M, Réthelyi JM, Bitter I, Rubino IA, Golimbet V, Kiemeney LA, van den Berg LH, Franke B, Jönsson EG, Farmer A, Stefansson H, Stefansson K, Collier DA. Biol Psychiatry. 2012 May 4. [Epub ahead of print]
Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified.
Redler S, Tazi-Ahnini R, Drichel D, Birch MP, Brockschmidt FF, Dobson K, Giehl KA, Refke M, Kluck N, Kruse R, Lutz G, Wolff H, Böhm M, Becker T, Nöthen MM, Betz RC, Messenger A. Exp Dermatol. 2012 May;21(5):390-393. doi: 10.1111/j.1600-0625.2012.01469.x.
Linking Amyloid-β and Tau: Amyloid-β Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton.
Zempel H, Mandelkow EM. Neurodegener Dis. 2012;10(1-4):64-72. Epub 2011 Dec 7.
Follow-Up Study of the First Genome-Wide Association Scan in Alopecia Areata: IL13 and KIAA0350 as Susceptibility Loci Supported with Genome-Wide Significance.
Jagielska D, Redler S, Brockschmidt FF, Herold C, Pasternack SM, Garcia Bartels N, Hanneken S, Eigelshoven S, Refke M, Barth S, Giehl KA, Kruse R, Lutz G, Wolff H, Blaumeiser B, Böhm M, Blume-Peytavi U, Becker T, Nöthen MM, Betz RC. J Invest Dermatol. 2012 Apr 26. doi: 10.1038/jid.2012.129. [Epub ahead of print]
Dietary intakes of berries and flavonoids in relation to cognitive decline.
Devore EE, Kang JH, Breteler MM, Grodstein F. Ann Neurol. 2012 Apr 26. doi: 10.1002/ana.23594. [Epub ahead of print]
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM. Acta Neuropathol. 2012 Apr 25. [Epub ahead of print]
DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder.
Håvik B, Degenhardt FA, Johansson S, Fernandes CP, Hinney A, Scherag A, Lybæk H, Djurovic S, Christoforou A, Ersland KM, Giddaluru S, O'Donovan MC, Owen MJ, Craddock N, Mühleisen TW, Mattheisen M, Schimmelmann BG, Renner T, Warnke A, Herpertz-Dahlmann B, Sinzig J, Albayrak O, Rietschel M, Nöthen MM, Bramham CR, Werge T, Hebebrand J, Haavik J, Andreassen OA, Cichon S, Steen VM, Le Hellard S. PLoS One. 2012;7(4):e35424. Epub 2012 Apr 23.
For gut's sake: NLRC4 inflammasomes distinguish friend from foe.
Franklin BS, Latz E. Nat Immunol. 2012 Apr 18;13(5):429-31. doi: 10.1038/ni.2289.
Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating.
Quednow BB, Brinkmeyer J, Mobascher A, Nothnagel M, Musso F, Gründer G, Savary N, Petrovsky N, Frommann I, Lennertz L, Spreckelmeyer KN, Wienker TF, Dahmen N, Thuerauf N, Clepce M, Kiefer F, Majic T, Mössner R, Maier W, Gallinat J, Diaz-Lacava A, Toliat MR, Thiele H, Nürnberg P, Wagner M, Winterer G. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6271-6. Epub 2012 Mar 26.
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: A European multicenter study.
Hammer C, Cichon S, Mühleisen TW, Haenisch B, Degenhardt F, Mattheisen M, Breuer R, Witt SH, Strohmaier J, Oruc L, Rivas F, Babadjanova G, Grigoroiu-Serbanescu M, Hauser J, Röth R, Rappold G, Rietschel M, Nöthen MM, Niesler B. Translational Psychiatry (2012) 2, e103; doi:10.1038/tp.2012.30
Methylmalonate impairs mitochondrial respiration supported by NADH-linked substrates: Involvement of mitochondrial glutamate metabolism.
Melo DR, Mirandola SR, Assunção NA, Castilho RF. J Neurosci Res. 2012 Jun;90(6):1190-9. doi: 10.1002/jnr.23020. Epub 2012 Feb 20.
Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age.
Nieratschker V, Grosshans M, Frank J, Strohmaier J, von der Goltz C, El-Maarri O, Witt SH, Cichon S, Nöthen MM, Kiefer F, Rietschel M. Addict Biol. 2012 Apr 16. doi: 10.1111/j.1369-1600.2012.00459.x. [Epub ahead of print]
Common variants at 6q22 and 17q21 are associated with intracranial volume.
the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT Jr, Niessen WJ, Destefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR Jr, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen AL, Pennell CE, Thiering E, Steegers EA, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin MR, McCarthy MI, Grant SF, Pourcain BS, Timpson NJ, Smith GD, Sovio U, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Jaddoe VW, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH Jr, Schmidt H, Launer LJ, Breteler MM, Decarli C; Early Growth Genetics (EGG) Consortium, Adair LS, Ang W, Atalay M, van Beijsterveldt T, Bergen N, Benke K, Berry D, Coin L, Davis OS, Elliott P, Flexeder C, Frayling T, Gaillard R, Groen-Blokhuis M, Goh LK, Haworth CM, Hadley D, Hedebrand J, Hinney A, Hirschhorn JN, Holloway JW, Holst C, Jan Hottenga J, Horikoshi M, Huikari V, Hypponen E, Kilpeläinen TO, Kirin M, Kowgier M, Lakka HM, Lange LA, Lawlor DA, Lehtimäki T, Lewin A, Lindgren C, Lindi V, Maggi R, Marsh J, Middeldorp C, Millwood I, Murray JC, Nivard M, Nohr EA, Ntalla I, Oken E, Panoutsopoulou K, Pararajasingham J, Rodriguez A, Salem RM, Sebert S, Siitonen N, Strachan DP, Teo YY, Valcárcel B, Willemsen G, Zeggini E, Boomsma DI, Cooper C, Gillman M, Hocher B, Lakka TA, Mohlke KL, Dedoussis GV, Ong KK, Pearson ER, Price TS, Power C, Raitakari OT, Saw SM, Scherag A, Simell O, Sørensen TI, Wilson JF. Nat Genet. 2012 Apr 15;44(5):539-544. doi: 10.1038/ng.2245.
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Bis JC, Decarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, Destefano AL, Lambert JC, Jack CR Jr, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM; the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT Jr, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S. Nat Genet. 2012 Apr 15;44(5):545-551. doi: 10.1038/ng.2237.
Common variants at 12q15 and 12q24 are associated with infant head circumference.
Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bønnelykke K, Buxton JL, Charoen P, Chawes BL, Eriksson J, Evans DM, Hofman A, Kemp JP, Kim CE, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Müller-Nurasyid M, O'Reilly PF, Prokopenko I, Rivadeneira F, Steegers EA, Sunyer J, Tiesler C, Yaghootkar H; The Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Consortium, Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Coker LH, Longstreth WT Jr, Niessen WJ, Destefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR Jr, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH Jr, Schmidt H, Launer LJ, Breteler MM, Decarli C, Breteler MM, Debette S, Fornage M, Gudnason V, Launer LJ, van der Lugt A, Mosley TH Jr, Seshadri S, Smith AV, Vernooij MW; Early Genetics & Lifecourse Epidemiology (EAGLE) Consortium, Ang W, van Beijsterveldt T, Bergen N, Benke K, Berry D, Bradfield JP, Charoen P, Coin L, Cousminer DL, Das S, Elliott P, Evans DM, Frayling T, Freathy RM, Gaillard R, Groen-Blokhuis M, Guxens M, Hadley D, Hottenga JJ, Huikari V, Hypponen E, Kaakinen M, Kowgier M, Lawlor DA, Lewin A, Lindgren C, Marsh J, Middeldorp C, Millwood I, Mook-Kanamori DO, Nivard M, O'Reilly PF, Palmer LJ, Prokopenko I, Rodriguez A, Sebert S, Sovio U, St Pourcain B, Standl M, Strachan DP, Sunyer J, Taal HR, Thiering E, Tiesler C, Uitterlinden AG, Valcárcel B, Warrington NM, White S, Willemsen G, Yaghootkar H, Boomsma DI, Estivill X, Grant SF, Hakonarson H, Hattersley AT, Heinrich J, Jaddoe VW, Jarvelin MR, McCarthy MI, Pennell CE, Power C, Timpson NJ, Widen E, Blakemore AI, Chiavacci RM, Feenstra B, Fernandez-Banet J, Grant SF, Hartikainen AL, van der Heijden AJ, Iñiguez C, Lathrop M, McArdle WL, Mølgaard A, Newnham JP, Palmer LJ, Palotie A, Pouta A, Ring SM, Sovio U, Standl M, Uitterlinden AG, Wichmann HE, Vissing NH, Decarli C, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VW; Early Growth Genetics (EGG) Consortium, Adair LS, Ang W, Atalay M, van Beijsterveldt T, Bergen N, Benke K, Berry D, Bradfield JP, Charoen P, Coin L, Cousminer DL, Das S, Davis OS, Elliott P, Evans DM, Feenstra B, Flexeder C, Frayling T, Freathy RM, Gaillard R, Geller F, Groen-Blokhuis M, Goh LK, Guxens M, Haworth CM, Hadley D, Hedebrand J, Hinney A, Hirschhorn JN, Holloway JW, Holst C, Hottenga JJ, Horikoshi M, Huikari V, Hypponen E, Iñiguez C, Kaakinen M, Kilpeläinen TO, Kirin M, Kowgier M, Lakka HM, Lange LA, Lawlor DA, Lehtimäki T, Lewin A, Lindgren C, Lindi V, Maggi R, Marsh J, Middeldorp C, Millwood I, Mook-Kanamori DO, Murray JC, Nivard M, Nohr EA, Ntalla I, Oken E, O'Reilly PF, Palmer LJ, Panoutsopoulou K, Pararajasingham J, Prokopenko I, Rodriguez A, Salem RM, Sebert S, Siitonen N, Sovio U, St Pourcain B, Strachan DP, Sunyer J, Taal HR, Teo YY, Thiering E, Tiesler C, Uitterlinden AG, Valcárcel B, Warrington NM, White S, Willemsen G, Yaghootkar H, Zeggini E, Boomsma DI, Cooper C, Estivill X, Gillman M, Grant SF, Hakonarson H, Hattersley AT, Heinrich J, Hocher B, Jaddoe VW, Jarvelin MR, Lakka TA, McCarthy MI, Melbye M, Mohlke KL, Dedoussis GV, Ong KK, Pearson ER, Pennell CE, Price TS, Power C, Raitakari OT, Saw SM, Scherag A, Simell O, Sørensen TI, Timpson NJ, Widen E, Wilson JF. Nat Genet. 2012 Apr 15;44(5):532-538. doi: 10.1038/ng.2238.
Identification of common variants associated with human hippocampal and intracranial volumes.
Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann O, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Mattingsdal M, Mohnke S, Maniega SM, Nho K, Nugent AC, O'Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M, Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N, Johnson MP, Kasperaviciute D, Kent JW Jr, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van den Heuvel M, van der Wee NJ, Van Haren NE, Veltman JA, Völzke H, Walker R, Westlye LT, Whelan CD, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Heinz A, Jack CR Jr, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW; the Alzheimer's Disease Neuroimaging Initiative (ADNI); EPIGEN Consortium; IMAGEN Consortium; Saguenay Youth Study Group (SYS), Bis JC, Ikram MA, Smith AV, Gudnason V, Tzourio C, Vernooij MW, Launer LJ, Decarli C, Seshadri S; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Andreassen OA, Apostolova LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de Zubicaray GI, Deary IJ, Donohoe G, de Geus EJ, Espeseth T, Fernández G, Glahn DC, Grabe HJ, Hardy J, Hulshoff Pol HE, Jenkinson M, Kahn RS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B, Nichols TE, Ophoff RA, Paus T, Pausova Z, Penninx BW, Potkin SG, Sämann PG, Saykin AJ, Schumann G, Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B, Wright MJ, Thompson PM. Nat Genet. 2012 Apr 15. doi: 10.1038/ng.2250. [Epub ahead of print]
Tau's role in the developing brain: implications for intellectual disability.
Sapir T, Frotscher M, Levy T, Mandelkow EM, Reiner O. Hum Mol Genet. 2012 Apr 15;21(8):1681-92. Epub 2011 Dec 21.
Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes.
Pedroso I, Lourdusamy A, Rietschel M, Nöthen MM, Cichon S, McGuffin P, Al-Chalabi A, Barnes MR, Breen G. Biol Psychiatry. 2012 Apr 12. [Epub ahead of print]
Calcium-Dependent Dephosphorylation of the Histone Chaperone DAXX Regulates H3.3 Loading and Transcription upon Neuronal Activation.
Michod D, Bartesaghi S, Khelifi A, Bellodi C, Berliocchi L, Nicotera P, Salomoni P. Neuron. 2012 Apr 12;74(1):122-35.
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
Mühleisen TW, Mattheisen M, Strohmaier J, Degenhardt F, Priebe L, Schultz CC, Breuer R, Meier S, Hoffmann P; GROUP Investigators, Rivandeneira F, Hofman A, Uitterlinden AG, Moebus S, Gieger C, Emeny R, Ladwig KH, Wichmann HE, Schwarz M, Kammerer-Ciernioch J, Schlösser RG, Nenadic I, Sauer H, Mössner R, Maier W, Rujescu D, Lange C, Ophoff RA, Schulze TG, Rietschel M, Nöthen MM, Cichon S. Schizophr Res. 2012 Apr 10. [Epub ahead of print]
Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample.
Degenhardt F, Priebe L, Herms S, Mattheisen M, Mühleisen TW, Meier S, Moebus S, Strohmaier J, Groß M, Breuer R, Lange C, Hoffmann P, Meyer-Lindenberg A, Heinz A, Walter H, Lucae S, Wolf C, Müller-Myhsok B, Holsboer F, Maier W, Rietschel M, Nöthen MM, Cichon S. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):263-273. doi: 10.1002/ajmg.b.32034. Epub 2012 Feb 17.
Spinocerebellar ataxia types 1, 2, 3 and 6: the clinical spectrum of ataxia and morphometric brainstem and cerebellar findings.
Jacobi H, Hauser TK, Giunti P, Globas C, Bauer P, Schmitz-Hübsch T, Baliko L, Filla A, Mariotti C, Rakowicz M, Charles P, Ribai P, Szymanski S, Infante J, van de Warrenburg BP, Dürr A, Timmann D, Boesch S, Fancellu R, Rola R, Depondt C, Schöls L, Zdzienicka E, Kang JS, Ratzka S, Kremer B, Stephenson DA, Melegh B, Pandolfo M, du Montcel ST, Borkert J, Schulz JB, Klockgether T. Cerebellum. 2012 Mar;11(1):155-66.
IL-1, quo vadis?
Grebe A, Latz E. Atherosclerosis. 2012 Mar 29. [Epub ahead of print]
Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption.
Jones EM, Dubey M, Camp PJ, Vernon BC, Biernat J, Mandelkow E, Majewski J, Chi EY. Biochemistry. 2012 Mar 27;51(12):2539-50. Epub 2012 Mar 14.
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C, Solfrizzi V, Sorbi S, Arosio B, Spalletta G, Siciliano G, Epelbaum J, Hannequin D, Dartigues JF, Tzourio C, Berr C, Schrijvers EM, Rogers R, Tosto G, Pasquier F, Bettens K, Van Cauwenberghe C, Fratiglioni L, Graff C, Delepine M, Ferri R, Reynolds CA, Lannfelt L, Ingelsson M, Prince JA, Chillotti C, Pilotto A, Seripa D, Boland A, Mancuso M, Bossù P, Annoni G, Nacmias B, Bosco P, Panza F, Sanchez-Garcia F, Del Zompo M, Coto E, Owen M, O'Donovan M, Valdivieso F, Caffara P, Scarpini E, Combarros O, Buée L, Campion D, Soininen H, Breteler M, Riemenschneider M, Van Broeckhoven C, Alpérovitch A, Lathrop M, Trégouët DA, Williams J, Amouyel P. Mol Psychiatry. 2012 Mar 20. doi: 10.1038/mp.2012.14. [Epub ahead of print]
Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells.
Thier M, Wörsdörfer P, Lakes YB, Gorris R, Herms S, Opitz T, Seiferling D, Quandel T, Hoffmann P, Nöthen MM, Brüstle O, Edenhofer F. Cell Stem Cell. 2012 Apr 6;10(4):473-9. Epub 2012 Mar 22.
Linkage-Disequilibrium-Based Binning Affects the Interpretation of GWASs.
Christoforou A, Dondrup M, Mattingsdal M, Mattheisen M, Giddaluru S, Nöthen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Jonassen I, Steen VM, Puntervoll P, Le Hellard S. Am J Hum Genet. 2012 Apr 6;90(4):727-33. Epub 2012 Mar 22.
CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.
Poppensieker K, Otte DM, Schürmann B, Limmer A, Dresing P, Drews E, Schumak B, Klotz L, Raasch J, Mildner A, Waisman A, Scheu S, Knolle P, Förster I, Prinz M, Maier W, Zimmer A, Alferink J. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3897-902. Epub 2012 Feb 21.
Integrated Genome-Wide Pathway Association Analysis with INTERSNP.
Herold C, Mattheisen M, Lacour A, Vaitsiakhovich T, Angisch M, Drichel D, Becker T. Hum Hered. 2012 Mar 7;73(2):63-72. [Epub ahead of print]
Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease: EFFECTS ON MITOCHONDRIAL TRANSPORT.
Matenia D, Hempp C, Timm T, Eikhof A, Mandelkow EM. J Biol Chem. 2012 Mar 9;287(11):8174-86. Epub 2012 Jan 11.
Distinct patterns of cognitive impairment in multiple system atrophy patients of cerebellar and parkinsonian predominance
I. Frommanna, T. Schmitz-Hübsch, K. Hoenig, M. Minnerop, I. Daum, U. Wüllner, M. Wagner. Basal Ganglia 2012. doi: dx.doi.org/10.1016/j.baga.2012.02.001. Epub 2012 Mar 16.
Hyperpolarization-activated cation current I(h) of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.
Surges R, Kukley M, Brewster A, Rüschenschmidt C, Schramm J, Baram TZ, Beck H, Dietrich D. Biochem Biophys Res Commun. 2012 Mar 30;420(1):156-60. Epub 2012 Mar 3.
Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata.
Forstbauer LM, Brockschmidt FF, Moskvina V, Herold C, Redler S, Herzog A, Hillmer AM, Meesters C, Heilmann S, Albert F, Alblas M, Hanneken S, Eigelshoven S, Giehl KA, Jagielska D, Blume-Peytavi U, Garcia Bartels N, Kuhn J, Hennies HC, Goebeler M, Jung A, Peitsch WK, Kortüm AK, Moll I, Kruse R, Lutz G, Wolff H, Blaumeiser B, Böhm M, Kirov G, Becker T, Nöthen MM, Betz RC. Eur J Hum Genet. 2012 Mar;20(3):326-32. doi: 10.1038/ejhg.2011.185. Epub 2011 Oct 26.
Amygdala Lesion Profoundly Alters Altruistic Punishment.
Scheele D, Mihov Y, Kendrick KM, Feinstein JS, Reich H, Maier W, Hurlemann R. Biol Psychiatry. 2012 Feb 24. [Epub ahead of print]
Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders.
Ersland KM, Christoforou A, Stansberg C, Espeseth T, Mattheisen M, Mattingsdal M, Hardarson GA, Hansen T, Fernandes CP, Giddaluru S, Breuer R, Strohmaier J, Djurovic S, Nöthen MM, Rietschel M, Lundervold AJ, Werge T, Cichon S, Andreassen OA, Reinvang I, Steen VM, Le Hellard S. PLoS One. 2012;7(2):e31687. Epub 2012 Feb 22.
Parkinson's disease. Perioperative management and anesthesia.[Morbus parkinson. Perioperatives management und anästhesie.]
Wüllner U, Standop J, Kaut O, Coenen V, Kalenka A, Wappler F. Anaesthesist. 2012 Feb;61(2):97-105.
Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease.
Wagner M, Wolf S, Reischies FM, Daerr M, Wolfsgruber S, Jessen F, Popp J, Maier W, Hüll M, Frölich L, Hampel H, Perneczky R, Peters O, Jahn H, Luckhaus C, Gertz HJ, Schröder J, Pantel J, Lewczuk P, Kornhuber J, Wiltfang J. Neurology. 2012 Feb 7;78(6):379-86. Epub 2012 Jan 11.
Neuron-specific Deletion of a Single Copy of the Insulin-like Growth Factor-1 Receptor Gene Reduces Fat Accumulation during Aging.
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Neurocognitive impairments in non-deprived smokers-results from a population-based multi-center study on smoking-related behavior.
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Automated measurement of local white matter lesion volume.
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Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.
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Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury.
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Cryo Electron Tomography of Herpes Simplex Virus during Axonal Transport and Secondary Envelopment in Primary Neurons.
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F Jessen, P Lewczuk, O Gür, W Block, G Ende, L Frölich, T Hammen, S Arlt, J Kornhuber, T Kucinski, J Popp, O Peters, W Maier, F Träber, J Wiltfang; J Alzheimers Dis. 2011;27(2):393-9.
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P Nicotera, H Hampel; Prog Neurobiol. 2011 Dec;95(4):496-7. Epub 2011 Jul 23.
Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.
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On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium.
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Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.
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S Bibow, MD Mukrasch, S Chinnathambi, J Biernat, C Griesinger, E Mandelkow, M Zweckstetter; Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11520-4. doi: 10.1002/anie.201105493. Epub 2011 Oct 11.
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P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan, D Poppe, J Doerr, J Ladewig, J Mertens, T Tüting, P Hoffmann, T Klockgether, BO Evert, U Wüllner, O Brüstle; Nature. 2011 Nov 23;480(7378):543-6. doi: 10.1038/nature10671.
Neurodegenerative processes in Huntington's disease.
D Bano, F Zanetti, Y Mende, P Nicotera; Cell Death Dis. 2011 Nov 10;2:e228. doi: 10.1038/cddis.2011.112.
Association Study of Nonsynonymous Single Nucleotide Polymorphisms in Schizophrenia.
N Carrera, M Arrojo, J Sanjuán, R Ramos-Ríos, E Paz, JJ Suárez-Rama, M Páramo, S Agra, J Brenlla, S Martínez, O Rivero, DA Collier, A Palotie, S Cichon, MM Nöthen, M Rietschel, D Rujescu, H Stefansson, S Steinberg, E Sigurdsson, Clair DS, Tosato S, Werge T, Stefansson K, González JC, Valero J, Gutiérrez-Zotes A, Labad A, Martorell L, Vilella E, A Carracedo, J Costas; Biol Psychiatry. 2011 Nov 10. [Epub ahead of print]
The presymptomatic stage of neurodegenerative disorders. [Das präsymptomatische Stadium neurodegenerativer Erkrankungen.]
C Klein, J Hagenah, B Landwehrmeyer, T Münte, T Klockgether, Nervenarzt. 2011 Aug; 82(8):994-1001.
Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model.
A Sydow, A Van der Jeugd, F Zheng, T Ahmed, D Balschun, O Petrova, D Drexler, L Zhou, G Rune, E Mandelkow, R D'Hooge, C Alzheimer, EM Mandelkow; J Mol Neurosci. 2011 Nov;45(3):432-7. Epub 2011 Aug 6.
The Rotterdam Scan Study: design and update up to 2012.
MA Ikram, A van der Lugt, WJ Niessen, GP Krestin, PJ Koudstaal, A Hofman, MM Breteler, MW Vernooij; Eur J Epidemiol. 2011 Oct 16. [Epub ahead of print]
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
Y Shi, Z Li, Q Xu, T Wang, T Li, J Shen, F Zhang, J Chen, G Zhou, W Ji, B Li, Y Xu, D Liu, P Wang, P Yang, B Liu, W Sun, C Wan, S Qin, G He, S Steinberg, S Cichon, T Werge, E Sigurdsson, S Tosato, A Palotie, MM Nöthen, M Rietschel, RA Ophoff, DA Collier, D Rujescu, DS Clair, H Stefansson, K Stefansson, J Ji, Q Wang, W Li, L Zheng, H Zhang, G Feng, L He; Nat Genet. 2011 Oct 30;43(12):1224-7. doi: 10.1038/ng.980.
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
X Li, Y Kumar, H Zempel, EM Mandelkow, J Biernat, E Mandelkow; EMBO J. 2011 Oct 18;30(23):4825-37. doi: 10.1038/emboj.2011.376.
Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition
MV Schmidt, JP Schülke, C Liebl, M Stiess, C Avrabos, J Bock, GM Wochnik, HA Davies, N Zimmermann, SH Scharf, D Trümbach, W Wurst, W Zieglgänsberger, C Turck, F Holsboer, MG Stewart, F Bradke, M Eder, MB Müller, T Rein; Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17213-8. Epub 2011 Oct 3.
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
G Lippi, JR Steinert, EL Marczylo, S D'Oro, R Fiore, ID Forsythe, G Schratt, M Zoli, P Nicotera, KW Young;J Cell Biol. 2011 Sep 19;194(6):889-904.
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau
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Mechanical Thrombectomy Compared to Local-Intraarterial Thrombolysis in Carotid T and Middle Cerebral Artery Occlusions - A Single Center Experience
M Möhlenbruch, M Seifert, T Okulla, U Wüllner, DR Hadizadeh, M Nelles, S Greschus, K Wilhelm, HH Schild, T Klockgether, H Urbach; Clin Neuroradiol. 2011 Oct 5. [Epub ahead of print]
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G Petzold, V Murthy;Neuron. 2011 Sep 8;71(5):782-97.
Nitration of tyrosine 10 critically enhances amyloid ß aggregation and plaque formation
M Kummer, M Hermes, A Delekarte, T Hammerschmidt, S Kumar, D Terwel, J Walter, HC Pape, S König, S Roeber, F Jessen, T Klockgether, M Korte, M Heneka; Neuron. 2011 Sep 8;71(5):833-44.
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo
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The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect.
S Gispert, A Kurz, S Waibel, P Bauer, I Liepelt, C Geisen, AD Gitler, T Becker, M Weber, D Berg, PM Andersen, R Krüger, O Riess, AC Ludolph, G Auburger; Neurobiol Dis. 2011 Aug 25. [Epub ahead of print]
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D Neukirchen, F Bradke; Semin Cell Dev Biol. 2011 Aug 22. [Epub ahead of print]
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H Leicht, S Heinrich, D Heider, C Bachmann, H Bickel, H van den Bussche, A Fuchs, M Luppa, W Maier, E Mösch, M Pentzek, SG Rieder-Heller, F Tebarth, J Werle, S Weyerer, B Wiese, T Zimmermann, HH König; Acta Psychiatr Scand. 2011 Aug 13. doi: 10.1111/j.1600-0447.2011.01741.x. [Epub ahead of print]
Proteasomal Dysfunction and Endoplasmic Reticulum Stress Enhance Trafficking of Prion Protein Aggregates through the Secretory Pathway and Increase Accumulation of Pathologic Prion Protein.
M Nunziante, K Ackermann, K Dietrich, H Wolf, L Gädtke, S Gilch, I Vorberg, M Groschup, HM Schätzl; J Biol Chem. 2011 Sep 30;286(39):33942-53. Epub 2011 Aug 11.
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Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss
S Redler, MP Birch, D Drichel, K Dobson, FF Brockschmidt, R Tazi-Ahnini, KA Giehl, N Kluck, R Kruse, G Lutz, H Wolff, T Becker, MM Nöthen, AG Messenger, RC Betz; Br J Dermatol. 2011 Sep;165(3):703-705. doi: 10.1111/j.1365-2133.2011.10456.x. Epub 2011 Aug 4.
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3
J Araujo, P Breuer, S Dieringer, S Krauss, S Dorn, K Zimmermann, A Pfeifer, T Klockgether, U Wuellner, BO Evert, Human Molecular Genetics, 2011 Aug 1, 20 (15) art. no. ddr197, pp 2928-2941.
Live longer, suffer more? Trends in life expectancy and health
G Doblhammer, D Kreft; Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011 Aug;54(8):907-14.
Common variation at 10p12.31 near MLLT10 influences meningioma risk
SE Dobbins, P Broderick, B Melin, M Feychting, C Johansen, U Andersson, T Bräignnnström, J Schramm, B Olver, A Lloyd, YP Ma, FJ Hosking, S Lönn, A Ahlbom, R Henriksson, MJ Schoemaker, SJ Hepworth, P Hoffmann, TW Mühleisen, MM Nöthen, S Moebus, L Eisele, M Kosteljanetz, K Muir, A Swerdlow, M Simon, RS Houlston; Nat Genet. 2011 Jul 31;43(9):825-7. doi: 10.1038/ng.879.
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: A meta-analysis of genetic studies and randomised trials
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Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
N Striepens, KM Kendrick, W Maier, R Hurlemann; Front Neuroendocrinol. 2011 Oct;32(4):426-50. Epub 2011 Jul 23.
Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy.
V Koppelmans, SB Schagen, MMF Poels, W Boogerd, C Seynaeve, Avd Lugt, MMB Breteler, European Journal of Cancer, 2011 Jul 9, [Article in Press].
Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice.
D Ehninger, LP Wang, F Klempin, B Römer, H Kettenmann, G Kempermann; Cell Tissue Res. 2011 Jul;345(1):69-86. Epub 2011 Jun 21.
Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering.
AV Shkumatov, S Chinnathambi, E Mandelkow, DI Svergun; Proteins. 2011 Jul;79(7):2122-31. doi: 10.1002/prot.23033. Epub 2011 May 10.
Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.
D Ehninger, AJ Silva; Behav Genet. 2011 May;41(3):357-63. doi: 10.1007/s10519-010-9398-1. Epub 2010 Sep 30.
On the follow-up of genome-wide association studies: an overall test for the most promising SNPs
Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C, Genet Epidemiol. 2011 Jul;35(5):303-9. doi: 10.1002/gepi.20578. Epub 2011 Mar 3.
Competing Interactions Stabilize Pro- and Anti-aggregant Conformations of Human Tau
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Milestones in ataxia
Klockgether T, Paulson H, Mov Disord. 2011 May;26(6):1134-41. doi: 10.1002/mds.23559.
Control of mTORC1 signaling by the Opitz syndrome protein MID1.
Liu E, Knutzen CA, Krauss S, Schweiger S, Chiang GG, Proc Natl Acad Sci U S A. 2011 May 24;108(21):8680-5. Epub 2011 May 9
Ageing, Neuronal Connectivity and Brain Disorders: An Unsolved Ripple Effect.
Bano D, Agostini M, Melino G, Nicotera P, Mol Neurobiol. 2011 Apr;43(2):124-30. Epub 2011 Jan 15.
Rita's 102!!
R Levi-Montalcini, RA Knight, P Nicotera, G Nisticó, N Bazan, G Melino; Mol Neurobiol. 2011 Apr;43(2):77-9.
p73: a multifunctional protein in neurobiology.
R Killick, M Niklison-Chirou, R Tomasini, D Bano, A Rufini, F Grespi, T Velletri, P Tucci, BS Sayan, F Conforti, E Gallagher, P Nicotera, TW Mak, G Melino, RA Knight, M Agostini; Mol Neurobiol. 2011 Apr;43(2):139-46. Epub 2011 Mar 8.
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.
Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, Glynn P, Cain K, Kyriacou CP, Giorgini F, Nicotera P, Cell Death Differ. 2011 Feb;18(2):191-200. Epub 2010 Nov 19.
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion.
I Hafner-Bratkovic, R Bester, P Pristovsek, L Gaedtke, P Veranic, J Gaspersic, M Mancek-Keber, M Avbelj, M Polymenidou, C Julius, A Aguzzi, I Vorberg, R Jerala;
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Mapping out biomarkers for Alzheimer disease.
Breteler MMB , JAMA. 2011 Jan 19;305(3):304-5.
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, Riemenschneider M, Owen M, Harold D, Hollingworth P, Cellini E, Sorbi S, Nacmias B, Takeda M, Pericak-Vance MA, Haines JL, Younkin S, Williams J, Van Broeckhoven C, Farrer LA, St George-Hyslop PH, Mayeux R, Arch Neurol. 2011 Jan;68(1):99-106.
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.
S Garg, T Timm, EM Mandelkow, E Mandelkow, Y Wang; Neurobiol Aging. 2011 Jan;32(1):1-14. Epub 2010 Oct 18.
Cell death mechanisms and their implications in toxicology.
Orrenius S, Nicotera P, Zhivotovsky B, Toxicol Sci. 2011 Jan;119(1):3-19. Epub 2010 Sep 9.
Why and how physical activity experience-induced brain plasticity.
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Increased Levels of Anxiety-related Behaviors in a Tsc2 Dominant Negative Transgenic Mouse Model of Tuberous Sclerosis.
D Ehninger, A J Silva; SpringerLink
p73 regulates maintenance of neural stem cell.
M Agostini, P Tucci, H Chen, RA Knight, D Bano, P Nicotera, F McKeon, G Melino; Biochem Biophys Res Commun. 2010 Dec 3.
Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
E Ziviani, G Lippi, D Bano, E Munarriz, S Guiducci, M Zoli, KW Young, P Nicotera; EMBO Journal. 2010 Nov 26; doi: EMBOJ.2010.279
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
E Kickstein, S Krauss, P Thornhill, D Rutschow, R Zeller, J Sharkey, R Williamson, M Fuchs, A Köhler, H Glossmann, R Schneider, C Sutherland, S Schweiger; PNAS. 2010 Nov 22; doi:10.1073/pnas.0912793107
A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of CA (v)2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons.
JY Park, S Remy, J Varela, DC Cooper, S Chung, HW Kang, JH Lee, N Spruston; PLoS Biol. 2010 Nov 16; 8(11):e1000534.
Callosal tissue loss in multiple system atrophy-A one-year follow-up study.
M Minnerop, E Lüders, K Specht, J Ruhlmann, N Schimke, PM Thompson, YY Chou, AW Toga, M Abele, U Wüllner, T Klockgether; Mov Disord. 2010 Nov 15.
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
D Ehninger, A J Silva; Trends in Molecular Medicine. 2010 Nov 5
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Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons.
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Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.
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Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.
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Feasible and Successful: Genome-Wide Interaction Analysis Involving All 1.9 x 1011 Pair-Wise Interaction Tests
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Nuclear pore complex during neuronal degeneration: Cracking the last barrier!
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The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development
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Cell Death and Disease: a new journal for a central area of pathophysiology.
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INTERSNP: genome-wide interaction analysis guided by a priori information.
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