Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.
Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV. Nat Neurosci. 2013 May 5. doi: 10.1038/nn.3395. [Epub ahead of print]
Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling.
Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C. J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013.
Prion disease: a tale of folds and strains.
Kretzschmar H, Tatzelt J. Brain Pathol. 2013 May;23(3):321-32. doi: 10.1111/bpa.12045.
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging.
Wardlaw JM, Smith C, Dichgans M. Lancet Neurol. 2013 May;12(5):483-97. doi: 10.1016/S1474-4422(13)70060-7.
Mutations in ap1b1 Cause Mistargeting of the Na(+)/K(+)-ATPase Pump in Sensory Hair Cells.
Clemens Grisham R, Kindt K, Finger-Baier K, Schmid B, Nicolson T. PLoS One. 2013 Apr 12;8(4):e60866. doi: 10.1371/journal.pone.0060866. Print 2013.
Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V. Immunity. 2013 Apr 18;38(4):655-68. doi: 10.1016/j.immuni.2012.12.004. Epub 2013 Apr 11.
Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease.
Müller SK, Bender A, Laub C, Högen T, Schlaudraff F, Liss B, Klopstock T, Elstner M. Neurobiol Aging. 2013 Apr 6. pii: S0197-4580(13)00116-4. doi: 10.1016/j.neurobiolaging.2013.03.016. [Epub ahead of print]
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog glia.
Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M. Cell Stem Cell. 2013 Apr 4;12(4):426-39. doi: 10.1016/j.stem.2013.01.019.
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF. Proteomics. 2013 May;13(9):1519-27. doi: 10.1002/pmic.201200582. Epub 2013 Apr 2.
Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration.
Dormann D, Haass C. Mol Cell Neurosci. 2013 Apr 2. pii: S1044-7431(13)00048-1. doi: 10.1016/j.mcn.2013.03.006. [Epub ahead of print]
Cell-to-cell propagation of infectious cytosolic protein aggregates.
Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schätzl HM, Bano D, Vorberg IM. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5951-6. doi: 10.1073/pnas.1217321110. Epub 2013 Mar 18.
Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.
Pfeiffer NV, Dirndorfer D, Lang S, Resenberger UK, Restelli LM, Hemion C, Miesbauer M, Frank S, Neutzner A, Zimmermann R, Winklhofer KF, Tatzelt J. EMBO J. 2013 Apr 3;32(7):1036-51. doi: 10.1038/emboj.2013.46. Epub 2013 Mar 12.
The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO.
Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF. Mol Cell. 2013 Mar 7;49(5):908-21. doi: 10.1016/j.molcel.2013.01.036. Epub 2013 Feb 28.
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Wefers B, Meyer M, Ortiz O, Hrabé de Angelis M, Hansen J, Wurst W, Kühn R. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3782-7. doi: 10.1073/pnas.1218721110. Epub 2013 Feb 20.
Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.
Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B. Neurobiol Aging. 2013 Jul;34(7):1779-89. doi: 10.1016/j.neurobiolaging.2013.01.020. Epub 2013 Mar 6.
Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
Poggi M, Kara I, Brunel JM, Landrier JF, Govers R, Bonardo B, Fluhrer R, Haass C, Alessi MC, Peiretti F. Biochim Biophys Acta. 2013 Mar;1833(3):602-12. doi: 10.1016/j.bbamcr.2012.11.009. Epub 2012 Nov 16.
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4986-91. doi: 10.1073/pnas.1218311110. Epub 2013 Mar 1.
Anti-Prion Drug mPPIg5 Inhibits PrPC Conversion to PrPSc
McCarthy JM, Franke M, Resenberger UK, Waldron S, Simpson JC, Tatzelt J, Appelhans D, Rogers MS. PLoS One. 2013;8(1):e55282. doi: 10.1371/journal.pone.0055282. Epub 2013 Jan 28.
Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, Roveri A, Toppo S, Ursini F, Zaccarin M, Maiorino M. Biochim Biophys Acta. 2013 Jun;1830(6):3846-57. doi: 10.1016/j.bbagen.2013.02.017. Epub 2013 Feb 27.
Therapeutic effectiveness of botulinum neurotoxin A: Potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25.
Lawrence GW, Ovsepian SV, Wang J, Aoki KR, Dolly JO. Neuropharmacology. 2013 Jul;70:287-95. doi: 10.1016/j.neuropharm.2013.02.012. Epub 2013 Feb 26.
Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in brafV637 ERT2 mice.
Ortiz O, Wurst W, Kühn R. Genesis. 2013 Feb 26:1-8. doi: 10.1002/dvg.22386. [Epub ahead of print]
Accuracy of the National Institute for Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy and Neuroprotection and Natural History in Parkinson Plus Syndromes Criteria for the Diagnosis of Progressive Supranuclear Palsy.
Respondek G, Roeber S, Kretzschmar H, Troakes C, Al-Sarraj S, Gelpi E, Gaig C, Chiu WZ, van Swieten JC, Oertel WH, Höglinger GU. Mov Disord. 2013 Apr;28(4):504-9. doi: 10.1002/mds.25327. Epub 2013 Feb 21.
Constitutive activation of β-Catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system.
Pöschl J, Grammel D, Dorostkar MM, Kretzschmar HA, Schüller U. Dev Biol. 2013 Feb 15;374(2):319-32. doi: 10.1016/j.ydbio.2012.12.001. Epub 2012 Dec 10.
Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes.
van Bebber F, Hruscha A, Willem M, Schmid B, Haass C. J Neurochem. 2013 Feb 14. doi: 10.1111/jnc.12198. [Epub ahead of print]
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D. Science. 2013 Mar 15;339(6125):1335-8. doi: 10.1126/science.1232927. Epub 2013 Feb 7.
