Portrait Engelhardt

Priv. Doz. Dr. Jakob von Engelhardt

Group Leader

German Center for Neurodegenerative Diseases (DZNE)
c/o DKFZ / A300
Im Neuenheimer Feld 280
69120 Heidelberg

+49 (0) 6221 / 42-3105
+49 (0) 228 / 43302-543 (Secretary)
+49 (0) 6221 / 42-3111

Group members

Name Phone Fax
Susanne Birnmeyer, Assistant +49 (0) 228/43302-543
Muhammad Aslam, Postdoc +49 (0) 6221 / 4231-19 +49 (0) 6221 / 4231-11
Eric Jacobi, Postdoc +49 (0) 6221 / 4231-20 +49 (0) 6221 / 4231-11
Michaela Müller, Ph.D. Student +49 (0) 6221 / 4231-20 +49 (0) 6221 / 4231-11
Further group members (third party funding)
Sonia Ruggieri, Ph.D. Student +49 (0) 6221 / 4231-21 +49 (0) 6221 / 4231-11
Xufeng Chen, Ph.D. Student +49 (0) 6221 / 4231-21 +49 (0) 6221 / 4231-11
Sabine Thewes, Ph.D. Student +49 (0) 6221 / 4231-19 +49 (0) 6221 / 4231-07
Marcel Kegel, Ph.D. Student +49 (0) 6221 / 4231-20 +49 (0) 6221 / 4231-07
Anwar Ullah, DAAD Student +49 (0) 6221 / 4231-19 +49 (0) 6221 / 4231-07

Selected Publications

Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.

Farrow P, Khodosevich K, Sapir Y, Schulmann A, Aslam M, Stern-Bach Y, Monyer H, von Engelhardt J. Elife. 2015 Dec 1;4. pii: e09693. doi: 10.7554/eLife.09693. [Epub ahead of print]

Modulation of AMPA receptor function by auxiliary proteins.

Monyer H, von Engelhardt J (2015) Neuroforum. 6(2): 39-48

GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice.

von Engelhardt J, Bocklisch C, Tönges L, Herb A, Mishina M, Monyer H (2015) Frontiers in Cellular Neuroscience. 3.25.

Coexpressed Auxiliary Subunits Exhibit Distinct Modulatory Profiles on AMPA Receptor Function.

Khodosevich K, Jacobi E, Farrow P, Schulmann A, Rusu A, Zhang L, Sprengel R, Monyer H, and von EngelhardtJ. (2014) Neuron 83: 601-15

Connective Tissue Growth Factor Regulates Interneuron Survival and Information Processing in the Olfactory Bulb.

Khodosevich K, Lazarini F, von Engelhardt J, Kaneko H, Lledo PM, Monyer H. Neuron. 2013 Sep 18;79(6):1136-51.

Pannexins in ischemia-induced neurodegeneration.

Bargiotas P, Krenz A, Hormuzdi SG, Ridder DA, Herb A, Barakat W, Penuela S, von Engelhardt J, Monyer H, Schwaninger M (2011). Proc Natl Acad Sci U S A.

Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation.

Hundelt M, Fath T, Selle K, Oesterwind K, Jordan J, Schultz C, Gotz J, von Engelhardt J, Monyer H, Lewejohann L, Sachser N, Bakota L, Brandt R (2011). Neurobiol Aging 32:991-1006.

5-HT3A Receptor-Bearing White Matter Interstitial GABAergic Interneurons Are Functionally Integrated into Cortical and Subcortical Networks

von Engelhardt J, Khrulev S, Eliava M, Wahlster S, Monyer H (2011). J Neurosci 31:16844-16854.

NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory.

Korotkova T, Fuchs EC, Ponomarenko A, von Engelhardt J, Monyer H (2010). Neuron 68:557-569.

CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus.

von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H (2010). Science 327:1518-1522.

Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone.

Inta D, Alfonso J, von Engelhardt J, Kreuzberg MM, Meyer AH, van Hooft JA, Monyer H (2008). Proc Natl Acad Sci U S A 105:20994-20999.

Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks.

von Engelhardt J, Doganci B, Jensen V, Hvalby O, Gongrich C, Taylor A, Barkus C, Sanderson DJ, Rawlins JN, Seeburg PH, Bannerman DM, Monyer H (2008). Neuron 60:846-860.

Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors.

von Engelhardt J, Coserea I, Pawlak V, Fuchs EC, Kohr G, Seeburg PH, Monyer H (2007). Neuropharmacology 53:10-17.

Functional characterization of intrinsic cholinergic interneurons in the cortex.

von Engelhardt J, Eliava M, Meyer AH, Rozov A, Monyer H (2007). J Neurosci 27:5633-5642.

The complete list of publications can be found here.

Curriculum Vitae

PD Dr. Jakob von Engelhardt studied medicine at the Philipps-University in Marburg. During his MD thesis (1999-2001), he investigated the influence of catecholamines on the cytokine-production of monocytes in the laboratory of Prof. P. von Wichert (Department of Internal Medicine, Philipps-University Marburg). From 2000-2003 he worked as a resident in Neurology at the Department of Neurology (Prof. W. Hacke) at the Ruprecht-Karl-University Heidelberg. He then joined the laboratory of Prof. H. Monyer (Department of Clinical Neurobiology, University Hospital Heidelberg) as a research associate. In 2007 he worked on sabbatical in the laboratory of Prof. G. Westbrook (Vollum Institute, Oregon Health and Science University, Portland, USA) and then again in 2010 in the laboratory of Prof. D. Choquet (University of Bordeaux 2, Physiologie Cellulaire de la Synapse, CNRS, Bordeaux, France). Since 2012 Jakob von Engelhardt has been a group leader at the DZNE in Bonn.

In his research, Jakob von Engelhardt is interested in function and regulation of glutamate receptors in hippocampal and cortical neurons. His lab uses electrophysiological, molecular biological and anatomical methods to investigate the role of glutamate receptors under physiological and pathophysiological conditions.

Areas of investigation/research focus

Our group investigates glutamatergic synaptic transmission in the hippocampus and cortex. We are particularly interested in what role different glutamate receptors (AMPA- and NMDA-receptors) and glutamate receptor-interacting proteins play in physiological and pathophysiological processes.

Mechanisms of Amyloid β pathology
One of the hallmarks of Alzheimer's disease is the accumulation of amyloid beta-peptide (Aβ) in the brain and its deposition as plaques. However, the current prevailing view is that soluble oligomeric Aβ is one of the main mediators of Alzheimer neurotoxicity, rather than the plaques. There are indications that glutamate receptors play a role in Aβ-mediated neurotoxicity. We use glutamate receptor transgenic mice to investigate the influence of this interaction on the physiology and anatomy of hippocampal and cortical neurons.

Regulation of synaptic communication via AMPA-receptor interacting proteins
AMPA receptors mediate most of the fast excitatory transmission in the central nervous system. Precise control of AMPA receptor number and localization on the cell membrane regulates synaptic strength and is thus of great importance for all cognitive processes. AMPA-receptor interacting proteins (TARPs, CKAMP44, cornichons and SynDig1) regulate receptor localization and function. We use heterologous expression systems and transgenic mice to analyze the influence of those proteins on the electrophysiological properties and localization of AMPA-receptors.