Publications
Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures.
HG Jahnke, A Braesigk, TG Mack, S Pönick, F Striggow, AA Robitzki; Biosens Bioelectron. 2012 Feb 15;32(1):250-8. Epub 2011 Dec 23.
Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.
V Velanac, T Unterbarnscheidt, W Hinrichs, MN Gummert, TM Fischer, MJ Rossner, A Trimarco, V Brivio, C Taveggia, M Willem, C Haass, W Möbius, KA Nave, MH Schwab; Glia. 2012 Feb;60(2):203-17. doi: 10.1002/glia.21255. Epub 2011 Nov 2.
Glial cells in adult neurogenesis.
J Morrens, W Van Den Broeck, G Kempermann; Glia. 2012 Feb;60(2):159-74. doi: 10.1002/glia.21247. Epub 2011 Nov 10.
Fear Processing and Social Networking in the Absence of a Functional Amygdala.
B Becker, Y Mihov, D Scheele, KM Kendrick, JS Feinstein, A Matusch, M Aydin, H Reich, H Urbach, AM Oros-Peusquens, NJ Shah, WS Kunz, TE Schlaepfer, K Zilles, W Maier, R Hurlemann; Biol Psychiatry. 2012 Jan 2. [Epub ahead of print]
The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain.
T Hamaguchi, YS Eisele, NH Varvel, BT Lamb, LC Walker, M Jucker; Acta Neuropathol. 2012 Jan;123(1):31-7. Epub 2011 Nov 20.
Differentiating Population Stratification from Genotyping Error Using Family Data.
R Sebro, C Lange, NM Laird, JJ Rogus, NJ Risch; Ann Hum Genet. 2012 Jan;76(1):42-52. doi: 10.1111/j.1469-1809.2011.00689.x. Epub 2011 Nov 23.
Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci.
H Singer, M Walier, N Nüsgen, C Meesters, F Schreiner, J Woelfle, R Fimmers, T Wienker, VM Kalscheuer, T Becker, R Schwaab, J Oldenburg, O El-Maarri; Hum Mol Genet. 2012 Jan 1;21(1):219-35. Epub 2011 Oct 4.
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
P Röhnert, UH Schröder, I Ziabreva, M Täger, KG Reymann, F Striggow; J Neurosci Res. 2012 Jan;90(1):193-202. doi: 10.1002/jnr.22754. Epub 2011 Oct 4.
Dendritic structural plasticity.
G Tavosanis; Dev. Dev Neurobiol. 2012 Jan;72(1):73-86. doi: 10.1002/dneu.20951.
Cryo Electron Tomography of Herpes Simplex Virus during Axonal Transport and Secondary Envelopment in Primary Neurons.
I Ibiricu, JT Huiskonen, K Döhner, F Bradke, B Sodeik, K Grünewald; PLoS Pathog. 2011 Dec;7(12):e1002406. Epub 2011 Dec 15.
Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy.
V Koppelmans, MB de Ruiter, F van der Lijn, W Boogerd, C Seynaeve, A van der Lugt, H Vrooman, WJ Niessen, MM Breteler, SB Schagen; Breast Cancer Res Treat. 2011 Dec 29. [Epub ahead of print]
Cost and care of patients with Alzheimer's disease: clinical predictors in German health care settings.
JP Reese, P Hessmann, G Seeberg, D Henkel, P Hirzmann, J Rieke, E Baum, F Dannhoff, MJ Müller, F Jessen, MB Geldsetzer, R Dodel; J Alzheimers Dis. 2011;27(4):723-36.
Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.
F Jessen, P Lewczuk, O Gür, W Block, G Ende, L Frölich, T Hammen, S Arlt, J Kornhuber, T Kucinski, J Popp, O Peters, W Maier, F Träber, J Wiltfang; J Alzheimers Dis. 2011;27(2):393-9.
Perspectives of worldwide translational biomarker research in neurodegenerative diseases.
P Nicotera, H Hampel; Prog Neurobiol. 2011 Dec;95(4):496-7. Epub 2011 Jul 23.
Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.
FF Brockschmidt, S Heilmann, JA Ellis, S Eigelshoven, S Hanneken, C Herold, S Moebus, MA Alblas, B Lippke, N Kluck, L Priebe, FA Degenhardt, RA Jamra, C Meesters, KH Jöckel, R Erbel, S Harrap, J Schumacher, H Fröhlich, R Kruse, AM Hillmer, T Becker, MM Nöthen; Br J Dermatol. 2011 Dec;165(6):1293-302. doi: 10.1111/j.1365-2133.2011.10708.x.
The future of Alzheimer's disease: the next 10 years.
H Hampel, D Prvulovic, S Teipel, F Jessen, C Luckhaus, L Frölich, MW Riepe, R Dodel, T Leyhe, L Bertram, W Hoffmann, F Faltraco; German Task Force on Alzheimer's Disease (GTF-AD); Prog Neurobiol. 2011 Dec;95(4):718-28. Epub 2011 Nov 22.
Multicenter stability of diffusion tensor imaging measures: A European clinical and physical phantom study.
SJ Teipel, S Reuter, B Stieltjes, J Acosta-Cabronero, U Ernemann, A Fellgiebel, M Filippi, G Frisoni, F Hentschel, F Jessen, S Klöppel, T Meindl, PJ Pouwels, KH Hauenstein, H Hampel; Psychiatry Res. 2011 Dec 30;194(3):363-71. Epub 2011 Nov 9.
Deregulated epigenetic gene-expression as a novel target to treat dementia and psychosis [Gestörte epigenetische regulation als angriffspunkt für neue substanzen zur behandlung von demenzen und psychosen].
A Fischer, P Falkai; Psychiatrie Volume 8, Issue 3, 2011, Pages 165-172
ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signalling.
Rehklau, K, Gurniak, CB, Conrad, M, Friauf, E, Ott, M, Rust, MB. (2011), Cell Death Differ. 2011 Dec 2. [Epub ahead of print]
Influence of Lithium Treatment on GDNF Serum and CSF Concentrations in Patients with Early Alzheimer΄s Disease.
G Straten, R Saur, C Laske, T Gasser, P Annas, H Basun, T Leyhe; Curr Alzheimer Res. 2011 Dec 1;8(8):853-9.
Cortical thickness changes following spatial navigation training in adulthood and aging.
E Wenger, S Schaefer, H Noack, S Kühn, J Mårtensson, HJ Heinze, E Düzel, L Bäckman, U Lindenberger, M Lövdén; Neuroimage. 2011 Nov 12. [Epub ahead of print]
The dynamic structure of filamentous tau.
S Bibow, MD Mukrasch, S Chinnathambi, J Biernat, C Griesinger, E Mandelkow, M Zweckstetter; Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11520-4. doi: 10.1002/anie.201105493. Epub 2011 Oct 11.
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
ML Moss, G Powell, MA Miller, L Edwards, B Qi, QX Sang, B De Strooper, I Tesseur, SF Lichtenthaler, M Taverna, JL Zhong, C Dingwall, T Ferdous, U Schlomann, P Zhou, LG Griffith, DA Lauffenburger, R Petrovich, JW Bartsch; J Biol Chem. 2011 Nov 25;286(47):40443-51. Epub 2011 Sep 28.
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan, D Poppe, J Doerr, J Ladewig, J Mertens, T Tüting, P Hoffmann, T Klockgether, BO Evert, U Wüllner, O Brüstle; Nature. 2011 Nov 23;480(7378):543-6. doi: 10.1038/nature10671.
Brain-Specific Inactivation of the Crhr1 Gene Inhibits Post-Dependent and Stress-Induced Alcohol Intake, but Does Not Affect Relapse-Like Drinking.
A Molander, V Vengeliene, M Heilig, W Wurst, JM Deussing, R Spanagel; Neuropsychopharmacology. 2011 Nov 23. doi: 10.1038/npp.2011.297. [Epub ahead of print]
Role of APP for dendritic spine formation and stability.
CK Jung, J Herms; Exp Brain Res. 2011 Nov 18. [Epub ahead of print]
An FMRI study on the role of serotonin in reactive aggression.
UM Krämer, J Riba, S Richter, TF Münte; PLoS One. 2011;6(11):e27668. Epub 2011 Nov 16.
Poor Trail Making Test Performance Is Directly Associated with Altered Dual Task Prioritization in the Elderly - Baseline Results from the TREND Study.
MA Hobert, R Niebler, SI Meyer, K Brockmann, C Becker, H Huber, A Gaenslen, J Godau, GW Eschweiler, D Berg, W Maetzler; PLoS One. 2011;6(11):e27831. Epub 2011 Nov 16.
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
P Broderick, D Chubb, DC Johnson, N Weinhold, A Försti, A Lloyd, B Olver, YP Ma, SE Dobbins, BA Walker, FE Davies, WA Gregory, JA Child, FM Ross, GH Jackson, K Neben, A Jauch, P Hoffmann, TW Mühleisen, MM Nöthen, S Moebus, IP Tomlinson, H Goldschmidt, K Hemminki, GJ Morgan, RS Houlston; Nat Genet. 2011 Nov 27;44(1):58-61. doi: 10.1038/ng.993.
Neurodegenerative processes in Huntington's disease.
D Bano, F Zanetti, Y Mende, P Nicotera; Cell Death Dis. 2011 Nov 10;2:e228. doi: 10.1038/cddis.2011.112.
Association Study of Nonsynonymous Single Nucleotide Polymorphisms in Schizophrenia.
N Carrera, M Arrojo, J Sanjuán, R Ramos-Ríos, E Paz, JJ Suárez-Rama, M Páramo, S Agra, J Brenlla, S Martínez, O Rivero, DA Collier, A Palotie, S Cichon, MM Nöthen, M Rietschel, D Rujescu, H Stefansson, S Steinberg, E Sigurdsson, Clair DS, Tosato S, Werge T, Stefansson K, González JC, Valero J, Gutiérrez-Zotes A, Labad A, Martorell L, Vilella E, A Carracedo, J Costas; Biol Psychiatry. 2011 Nov 10. [Epub ahead of print]
Intra- and inter-cortical motor excitability in Alzheimer's disease.
J Hoeppner, M Wegrzyn, J Thome, A Bauer, I Oltmann, J Buchmann, S Teipel; J Neural Transm. 2011 Nov 13. [Epub ahead of print]
Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.
S Lammich, F Kamp, J Wagner, B Nuscher, S Zilow, AK Ludwig, M Willem, C Haass; J Biol Chem. 2011 Dec 30;286(52):45063-72. Epub 2011 Nov 7.
Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model.
A Sydow, A Van der Jeugd, F Zheng, T Ahmed, D Balschun, O Petrova, D Drexler, L Zhou, G Rune, E Mandelkow, R D'Hooge, C Alzheimer, EM Mandelkow; J Mol Neurosci. 2011 Nov;45(3):432-7. Epub 2011 Aug 6.
Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on Mammalian male fertilizing ability.
A Noblanc, A Kocer, E Chabory, P Vernet, F Saez, R Cadet, M Conrad, JR Drevet; J Androl. 2011 Nov;32(6):641-50. Epub 2011 Mar 25.
Incidence of restless legs syndrome in two population-based cohort studies in Germany.
A Szentkiralyi, K Fendrich, W Hoffmann, S Happe, K Berger; Sleep Med. 2011 Oct;12(9):815-20.
Shorter stays for sicker patients in hospitals: where is nursing? [Schnellerer Durchlauf kränkerer Patienten im Krankenhaus: Wo bleibt die Pflege?]
S Bartholomeyczik; Ethik in der Medizin. 2011 Oct 30. pp. 1-11. Volume 23, Number 4, 315-325, DOI: 10.1007/s00481-011-0160-x
Description of the behaviour of wandering in people with dementia living in nursing homes - a review of the literature.
M Halek, S Bartholomeyczik; Scand J Caring Sci. 2011 Oct 28. doi: 10.1111/j.1471-6712.2011.00932.x. [Epub ahead of print]
Novel {gamma}-Secretase Enzyme Modulators Directly Target Presenilin Protein.
A Ebke, T Luebbers, A Fukumori, K Shirotani, C Haass, K Baumann, H Steiner;J Biol Chem. 2011 Oct 28;286(43):37181-6. Epub 2011 Sep 6.
BRI2 Protein Regulates {beta}-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE).
E Kilger, A Buehler, H Woelfing, S Kumar, SA Kaeser, A Nagarathinam, J Walter, M Jucker, J Coomaraswamy;J Biol Chem. 2011 Oct 28;286(43):37446-57. Epub 2011 Aug 26.
Serum lipid levels and the risk of intracerebral hemorrhage: the Rotterdam study.
RG Wieberdink, MM Poels, MW Vernooij, PJ Koudstaal, A Hofman, A van der Lugt, MM Breteler, MA Ikram; Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2982-9. Epub 2011 Sep 15.
On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium.
PJ Lipman, WK Yip, T AlChawa, KU Ludwig, E Mangold, C Lange; Genet Epidemiol. 2011 Dec;35(8):880-6. doi: 10.1002/gepi.20638.
Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential.
T Timm, JP von Kries, X Li, H Zempel, E Mandelkow, EM Mandelkow EM; J Biol Chem. 2011 Dec 2;286(48):41711-22. Epub 2011 Oct 7.
Role of presenilin1 in structural plasticity of cortical dendritic spines in vivo.
CK Jung, M Fuhrmann, K Honarnejad, F Van Leuven, J Herms; J Neurochem. 2011 Dec;119(5):1064-73. doi: 10.1111/j.1471-4159.2011.07503.x. Epub 2011 Oct 24.
Weighting models and weighting factors.
G Vosgerau, M Synofzik; Conscious Cogn. 2011 Oct 24. [Epub ahead of print]
Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease.
SP Schmid, ED Schleicher, A Cegan, C Deuschle, S Baur, AK Hauser, M Synofzik, K Srulijes, K Brockmann, D Berg, W Maetzler; Mov Disord. 2011 Oct 21. doi: 10.1002/mds.23984. [Epub ahead of print]
Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats.
RF Rosen, JJ Fritz, J Dooyema, AF Cintron, T Hamaguchi, JJ Lah, H Levine 3rd, M Jucker, LC Walker; J Neurochem. 2011 Oct 21. doi: 10.1111/j.1471-4159.2011.07551.x. [Epub ahead of print]
Rapid emergence of temporal and pulvinar lesions in MELAS mimicking Creutzfeldt-Jakob disease.
D Weiss, K Brockmann, T Nägele, T Gasser, R Krüger; Neurology. 2011 Aug 30;77(9):914.
Serum and Cerebrospinal Fluid Uric Acid Levels in Lewy Body Disorders: Associations with Disease Occurrence and Amyloid-β Pathway.
W Maetzler, AK Stapf, C Schulte, AK Hauser, S Lerche, I Wurster, E Schleicher, A Melms, D Berg; J Alzheimers Dis. 2011 Jan 1;27(1):119-26.
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
X Li, Y Kumar, H Zempel, EM Mandelkow, J Biernat, E Mandelkow; EMBO J. 2011 Oct 18;30(23):4825-37. doi: 10.1038/emboj.2011.376.
Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition
MV Schmidt, JP Schülke, C Liebl, M Stiess, C Avrabos, J Bock, GM Wochnik, HA Davies, N Zimmermann, SH Scharf, D Trümbach, W Wurst, W Zieglgänsberger, C Turck, F Holsboer, MG Stewart, F Bradke, M Eder, MB Müller, T Rein; Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17213-8. Epub 2011 Oct 3.
The influence of understanding diagnostics on perceived stress of nurses caring for nursing home residents with dementia
D Holle, M Halek, H Mayer, S Bartholomeyczik; Pflege. 2011 Oct;24(5):303-16.
The Nicastrin ectodomain adopts a highly thermostable structure
R Fluhrer, F Kamp, G Grammer, B Nuscher, H Steiner, K Beyer, C Haass; Biol Chem. 2011 Nov;392(11):995-1001.
Vagus nerve somatosensory evoked potentials in Parkinson's disease.
T Polak, D Weise, F Metzger, AC Ehlis, JB Langer, A Schramm, AJ Fallgatter, J Classen; J Neurol. 2011 Dec;258(12):2276-7. Epub 2011 May 11.
Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice
NJ Rupp, BM Wegenast-Braun, R Radde, ME Calhoun, M Jucker; Neurobiol Aging. 2011 Dec;32(12):2324.e1-6. Epub 2010 Oct 22.
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
Y Shi, Z Li, Q Xu, T Wang, T Li, J Shen, F Zhang, J Chen, G Zhou, W Ji, B Li, Y Xu, D Liu, P Wang, P Yang, B Liu, W Sun, C Wan, S Qin, G He, S Steinberg, S Cichon, T Werge, E Sigurdsson, S Tosato, A Palotie, MM Nöthen, M Rietschel, RA Ophoff, DA Collier, D Rujescu, DS Clair, H Stefansson, K Stefansson, J Ji, Q Wang, W Li, L Zheng, H Zhang, G Feng, L He; Nat Genet. 2011 Oct 30;43(12):1224-7. doi: 10.1038/ng.980.
Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone
J Hradsky, V Raghuram, PP Reddy, G Navarro, M Hupe, V Casado, PJ McCormick, Y Sharma, MR Kreutz, M Mikhaylova; J Biol Chem. 2011 Oct 21;286(42):36762-76. Epub 2011 Aug 30.
Kidney pathology precedes and predicts the pathological cascade of cerebrovascular lesions in stroke prone rats.
S Schreiber, CZ Bueche, C Garz, S Kropf, D Kuester, K Amann, HJ Heinze, M Goertler, KG Reymann, H Braun; PLoS One. 2011;6(10):e26287. Epub 2011 Oct 21.
The Rotterdam Scan Study: design and update up to 2012.
MA Ikram, A van der Lugt, WJ Niessen, GP Krestin, PJ Koudstaal, A Hofman, MM Breteler, MW Vernooij; Eur J Epidemiol. 2011 Oct 16. [Epub ahead of print]
Soluble A{beta} Seeds Are Potent Inducers of Cerebral {beta}-Amyloid Deposition.
F Langer, YS Eisele, SK Fritschi, M Staufenbiel, LC Walker, M Jucker; J Neurosci. 2011 Oct 12;31(41):14488-14495.
open PubMed Abstract
Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers.
K Brockmann, A Gröger, A Di Santo, I Liepelt, C Schulte, U Klose, W Maetzler, AK Hauser, R Hilker, B Gomez-Mancilla, D Berg, T Gasser;Mov Disord. 2011 Oct 11. doi: 10.1002/mds.23991. [Epub ahead of print]
open PubMed Abstract
Absence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation.
MB Hartig, A Iuso, T Haack, T Kmiec, E Jurkiewicz, K Heim, S Roeber, V Tarabin, S Dusi, M Krajewska-Walasek, S Jozwiak, M Hempel, J Winkelmann, M Elstner, K Oexle, T Klopstock, W Mueller-Felber, T Gasser, C Trenkwalder, V Tiranti, H Kretzschmar, G Schmitz, TM Strom, T Meitinger, H Prokisch; Am J Hum Genet. 2011 Oct 7;89(4):543-50.
open PubMed Abstract
Mechanical Thrombectomy Compared to Local-Intraarterial Thrombolysis in Carotid T and Middle Cerebral Artery Occlusions - A Single Center Experience
M Möhlenbruch, M Seifert, T Okulla, U Wüllner, DR Hadizadeh, M Nelles, S Greschus, K Wilhelm, HH Schild, T Klockgether, H Urbach; Clin Neuroradiol. 2011 Oct 5. [Epub ahead of print]
Mutations in the PDYN gene (SCA23) are not a frequent cause of dominant ataxia in Central Europe
J Schicks, M Synofzik, C Beetz, F Schiele, L Schöls; Clinical Genetics, 80: 503–504. Article first published online: 5 OCT 2011. doi: 10.1111/j.1399-0004.2011.01651.x
Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo
F Bolze, N Rink, H Brumm, R Kühn, S Mocek, AE Schwarz, C Kless, H Biebermann, W Wurst, J Rozman, M Klingenspor; Pharmacogenomics J. 2011 Oct 4. doi: 10.1038/tpj.2011.43. [Epub ahead of print]
Excitability changes induced in the human auditory cortex by transcranial direct current stimulation: direct electrophysiological evidence.
T Zaehle, M Beretta, L Jäncke, CS Herrmann, P Sandmann; Exp Brain Res. 2011 Oct 1. [Epub ahead of print]
Validity, reliability, and feasibility of a quality of life questionnaire for people with dementia.
M Dichter, S Bartholomeyczik, J Nordheim, W Achterberg, M Halek; Z Gerontol Geriatr. 2011 Dec;44(6):405-410.
Neuropathology in mice expressing mouse alpha-synuclein
C Rieker, KK Dev, K Lehnhoff, S Barbieri, I Ksiazek, S Kauffmann, S Danner, H Schell, C Boden, MA Ruegg, PJ Kahle, H van der Putten, DR Shimshek; PLoS One. 2011;6(9):e24834. Epub 2011 Sep 26.
microRNA-34c is a novel target to treat dementias.
Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A. EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.327. [Epub ahead of print]
Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels
A Heyden, MCS Ionescu, S Romorini, BKracht, V Ghiglieri, P Calabresi, C Seidenbecher, F Angenstein, ED Gundelfinger; Cell Tissue Res. 2011 Sep 21. [Epub ahead of print]
Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages
BA Carlson, M-H Yoo, M Conrad, VN Gladyshev, DL Hatfield, JM Park; Mol Immunol. 2011 Sep 21. [Epub ahead of print]
Forebrain CRF1 modulates early-life stress-programmed cognitive deficits
X-D Wang, G Rammes, I Kraev, M Wolf, C Liebl, SH Scharf, CJ Rice, W Wurst, F Holsboer, JM Deussing, TZ Baram, MG Stewart, MB Müller, MV Schmidt; J Neurosci. 2011 Sep 21;31(38):13625-13634.
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
G Lippi, JR Steinert, EL Marczylo, S D'Oro, R Fiore, ID Forsythe, G Schratt, M Zoli, P Nicotera, KW Young;J Cell Biol. 2011 Sep 19;194(6):889-904.
Frequency and determinants of potential drug-drug interactions in an elderly population receiving regular home visits by GPs - results of the home medication review in the AGnES-studies
W Hoffmann, N Van Den Berg, JR Thyrian, T Fiss; Pharmacoepidemiol Drug Saf. 2011 Sep 15. doi: 10.1002/pds.2224. [Epub ahead of print]
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau
S Bibow, V Ozenne, J Biernat, M Blackledge, E Mandelkow, M Zweckstetter; J Am Chem Soc. 2011 Oct 12;133(40):15842-5. Epub 2011 Sep 15.
Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: Effect of different processing and analysis approaches on sample sizes.
SJ Teipel, O Peters, I Heuser, F Jessen, W Maier, L Froelich, S Arlt, MHüll, HJ Gertz, J Kornhuber, J Wiltfang, J Thome, O Rienhoff, T Meindl, H Hampel, M Grothe; World J Biol Psychiatry. 2011 Sep;12 Suppl 1:109-13.
Role of astrocytes in neurovascular coupling
G Petzold, V Murthy;Neuron. 2011 Sep 8;71(5):782-97.
Nitration of tyrosine 10 critically enhances amyloid ß aggregation and plaque formation
M Kummer, M Hermes, A Delekarte, T Hammerschmidt, S Kumar, D Terwel, J Walter, HC Pape, S König, S Roeber, F Jessen, T Klockgether, M Korte, M Heneka; Neuron. 2011 Sep 8;71(5):833-44.
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons
C Peng, L Aron, R Klein, M Li, W Wurst, N Prakash, W Le; J Neurosci. 2011 Sep 7;31(36):12802-12815.
miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
N Mellios, H Sugihara, J Castro, A Banerjee, C Le, A Kumar, B Crawford, J Strathmann, D Tropea, SS Levine, D Edbauer, M Sur; Nat Neurosci. 2011 Sep 4;14(10):1240-2. doi: 10.1038/nn.2909.
Quality features of German memory clinics - A cross-sectional study
S Lueke, N Kehrwieder, W Hoffmann, S Teipel, S Fleßa; Nervenarzt. 2011 Sep 2. [Epub ahead of print]
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo
I Hafner-Bratkovic, L Gaedtke, A Ondracka, P Veranic, I Vorberg, R Jerala; PLoS One. 2011;6(9):e24238. Epub 2011 Sep 1.
Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1
D Refojo, M Schweizer, C Kuehne, S Ehrenberg, C Thoeringer, AM Vogl, N Dedic, M Schumacher, G von Wolff, C Avrabos, C Touma, D Engblom, G Schütz, K-A Nave, M Eder, CT Wotjak, I Sillaber, F Holsboer, W Wurst, JM Deussing; Science. 2011 Sep 30;333(6051):1903-7. Epub 2011 Sep 1.
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
M Krohn, C Lange, J Hofrichter, K Scheffler, J Stenzel, J Steffen, T Schumacher, T Brüning, A-S Plath, F Alfen, A Schmidt, F Winter, K Rateitschak, A Wree, J Gsponer, LC Walker, J Pahnke; J Clin Invest. 2011 Oct 3;121(10):3924-31. doi: 10.1172/JCI57867. Epub 2011 Sep 1.
Biodistribution and brain permeability of the extracellular domain of neuregulin-1-β1
TW Rösler, C Depboylu, O Arias-Carrión, W Wozny, T Carlsson, M Höllerhage, WH Oertel, A Schrattenholz, GU Höglinger; Neuropharmacology. 2011 Dec;61(8):1413-8. Epub 2011 Aug 31.
The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase?
S Schreiber, CZ Bueche, C Garz, S Kropf, F Angenstein, J Goldschmidt, J Neumann, HJ Heinze, M Goertler, KG Reymann, H Braun; J Cereb Blood Flow Metab. 2011 Aug 31. doi: 10.1038/jcbfm.2011.122. [Epub ahead of print]
The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect.
S Gispert, A Kurz, S Waibel, P Bauer, I Liepelt, C Geisen, AD Gitler, T Becker, M Weber, D Berg, PM Andersen, R Krüger, O Riess, AC Ludolph, G Auburger; Neurobiol Dis. 2011 Aug 25. [Epub ahead of print]
open PubMed Abstract
Neuronal polarization and the cytoskeleton
D Neukirchen, F Bradke; Semin Cell Dev Biol. 2011 Aug 22. [Epub ahead of print]
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
M Neumann, E Bentmann, D Dormann, A Jawaid, M Dejesus-Hernandez, O Ansorge, S Roeber, HA Kretzschmar, DG Munoz, H Kusaka, O Yokota, L-C Ang, J Bilbao, R Rademakers, C Haass, IRA MacKenzie; Brain. 2011 Sep;134(Pt 9):2595-609. Epub 2011 Aug 19.
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
J Lisman, AA Grace, E Duzel; Trends Neurosci. 2011 Oct;34(10):536-47. Epub 2011 Aug 17.
Proteasomal Dysfunction and Endoplasmic Reticulum Stress Enhance Trafficking of Prion Protein Aggregates through the Secretory Pathway and Increase Accumulation of Pathologic Prion Protein.
M Nunziante, K Ackermann, K Dietrich, H Wolf, L Gädtke, S Gilch, I Vorberg, M Groschup, HM Schätzl; J Biol Chem. 2011 Sep 30;286(39):33942-53. Epub 2011 Aug 11.
open PubMed Abstract
Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss
S Redler, MP Birch, D Drichel, K Dobson, FF Brockschmidt, R Tazi-Ahnini, KA Giehl, N Kluck, R Kruse, G Lutz, H Wolff, T Becker, MM Nöthen, AG Messenger, RC Betz; Br J Dermatol. 2011 Sep;165(3):703-705. doi: 10.1111/j.1365-2133.2011.10456.x. Epub 2011 Aug 4.
Live longer, suffer more? Trends in life expectancy and health
G Doblhammer, D Kreft; Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011 Aug;54(8):907-14.
Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer´s disease
M Grothe, H Heinsen, SJ Teipel; Biol Psychiatry. 2011 Aug 3. [Epub ahead of print]
Common variation at 10p12.31 near MLLT10 influences meningioma risk
SE Dobbins, P Broderick, B Melin, M Feychting, C Johansen, U Andersson, T Bräignnnström, J Schramm, B Olver, A Lloyd, YP Ma, FJ Hosking, S Lönn, A Ahlbom, R Henriksson, MJ Schoemaker, SJ Hepworth, P Hoffmann, TW Mühleisen, MM Nöthen, S Moebus, L Eisele, M Kosteljanetz, K Muir, A Swerdlow, M Simon, RS Houlston; Nat Genet. 2011 Jul 31;43(9):825-7. doi: 10.1038/ng.879.
The cholinergic system in mild cognitive impairment and Alzheimer's disease: An in Vivo MRI and DTI study
SJ Teipel, T Meindl, L Grinberg, M Grothe, JL Cantero, MF Reiser, H-J Möller, H Heinsen, H Hampel; Hum Brain Mapp. 2011 Sep;32(9):1349-62. doi: 10.1002/hbm.21111. Epub 2010 Jul 29.
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
N Striepens, KM Kendrick, W Maier, R Hurlemann; Front Neuroendocrinol. 2011 Oct;32(4):426-50. Epub 2011 Jul 23.
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease
M Sharma, DM Maraganore, JPA Ioannidis, O Riess, JO Aasly, G Annesi, N Abahuni, AR Bentivoglio, A Brice, C Van Broeckhoven, M-C Chartier-Harlin, A Destée, A Djarmati, A Elbaz, M Farrer, C Ferrarese, JM Gibson, S Gispert, N Hattori, B Jasinska-Myga, C Klein, S Lesage, T Lynch, P Lichtner, J-C Lambert, AE Lang, GD Mellick, F De Nigris, G Opala, A Quattrone, C Riva, E Rogaeva, OA Ross, W Satake, PA Silburn, J Theuns, T Toda, H Tomiyama, RJ Uitti, KWirdefeldt, Z Wszolek, T Gasser, R Krüger; Neurobiol Aging. 2011 Nov;32(11):2108.e1-5. Epub 2011 Jul 22.
A genome-wide association study of aging
S Walter, G Atzmon, EW Demerath, ME Garcia, RC Kaplan, M Kumari, KL Lunetta, Y Milaneschi, T Tanaka, GJ Tranah, U Völker, L Yu, A Arnold, EJ Benjamin, R Biffar, AS Buchman, E Boerwinkle, D Couper, PL De Jager, DA Evans, TB Harris, W Hoffmann, A Hofman, D Karasik, DP Kiel, T Kocher, M Kuningas, LJ Launer, KK Lohman, PL Lutsey, J Mackenbach, K Marciante, BM Psaty, EM Reiman, JI Rotter, S Seshadri, MD Shardell, AV Smith, C van Duijn, J Walston, MC Zillikens, S Bandinelli, SE Baumeister, DA Bennett, L Ferrucci, V Gudnason, M Kivimaki, Y Liu, JM Murabito, AB Newman, H Tiemeier, N Franceschini; Neurobiol Aging. 2011 Nov;32(11):2109.e15-28. Epub 2011 Jul 22.
Olfactory neuron-specific expression of A30P alpha-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages
S Nuber, E Petrasch-Parwez, O Arias-Carrión, L Koch, Z Kohl, J Schneider, C Calaminus, R Dermietzel, A Samarina, J Boy, HP Nguyen, P Teismann, TP Velavan, PJ Kahle, S von Hörsten, M Fendt, R Krüger, O Riess; Neurobiol Dis. 2011 Nov;44(2):192-204. Epub 2011 Jul 5.
Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: Evidence from high-resolution fMRI
RM Krebs, D Heipertz, H Schuetze, E Duzel; Neuroimage. 2011 Sep 15;58(2):647-55. Epub 2011 Jun 24.
Influence of different cut-off values on the diagnosis of mild cognitive impairment in Parkinson's disease
I Liepelt-Scarfone, S Graeber, A Feseker, G Baysal, J Godau, A Gaenslen, W Maetzler, B Berg; Parkinsons Dis. 2011;2011:540843. Epub 2011 May 23.
JNK plays a key role in tau hyperphosphorylation in alzheimer's disease models
C Ploia, X Antoniou, A Sclip, V Grande, D Cardinetti, A Colombo, N Canu, L Benussi, R Ghidoni, G Forloni, T Borsello; J Alzheimers Dis. 2011 Jan 1;26(2):315-29.
Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of lewy body-associated dementias
W Maetzler, D Berg, M Synofzik, K Brockmann, J Godau, A Melms, T Gasser, S Hörnig, M Langkamp; J Alzheimers Dis. 2011;26(1):171-9.
Stem cell factor plasma levels are decreased in alzheimer's disease patients with fast cognitive decline after one-year follow-up period: The pythia-study
C Laske, K Sopova, N Hoffmann, E Stransky, K Hagen, AJ Fallgatter, K Stellos, T Leyhe; J Alzheimers Dis. 2011;26(1):39-45.
Effects of a 6-month cognitive intervention program on brain metabolism in amnestic mild cognitive impairment and mild alzheimer's disease
S Förster, VC Buschert, H-G Buchholz, SJ Teipel, U Friese, C Zach, C La Fougere, A Rominger, A Drzezga, H Hampel, P Bartenstein, K Buerger; J Alzheimers Dis. 2011;25(4):695-706.
Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild alzheimer's disease: A pilot study
VC Buschert, U Friese, SJ Teipel, P Schneider, W Merensky, D Rujescu, H-J Möller, H Hampel, K Buerger; J Alzheimers Dis. 2011;25(4):679-94.
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study
OA Ross, AI Soto-Ortolaza, MG Heckman, JO Aasly, N Abahuni, G Annesi, JA Bacon, S Bardien, M Bozi, A Brice, L Brighina, C Van Broeckhoven, J Carr, MC Chartier-Harlin, E Dardiotis, DW Dickson, NN Diehl, A Elbaz, C Ferrarese, A Ferraris, B Fiske, JM Gibson, R Gibson, GM Hadjigeorgiou, N Hattori, JP Ioannidis, B Jasinska-Myga, BS Jeon, YJ Kim, C Klein, R Kruger, E Kyratzi, S Lesage, CH Lin, T Lynch, DM Maraganore, GD Mellick, E Mutez, C Nilsson, G Opala, SS Park, A Puschmann, A Quattrone, M Sharma, PA Silburn, YH Sohn, L Stefanis, V Tadic, J Theuns, H Tomiyama, RJ Uitti, EM Valente, S van de Loo, DK Vassilatis, C Vilariño-Güell, LR White, K Wirdefeldt, ZK Wszolek, R-M Wu, MJ Farrer; Lancet Neurol. 2011 Oct;10(10):898-908. Epub 2011 Aug 30.
A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories
RC Agis-Balboa, D Arcos-Diaz, J Wittnam, N Govindarajan, K Blom, S Burkhardt, U Haladyniak, HY Agbemenyah, A Zovoilis, G Salinas-Riester, L Opitz, F Sananbenesi, A Fischer; EMBO J. 2011 Aug 26;30(19):4071-83. doi: 10.1038/emboj.2011.293.
Low frequency stimulation of the perforant pathway generates anesthesia-specific variations in neural activity and BOLD responses in the rat dentate gyrus
K Krautwald, F Angenstein; J Cereb Blood Flow Metab. 2011 Aug 24. doi: 10.1038/jcbfm.2011.126. [Epub ahead of print]
TDP-43 and FUS/TLS: Cellular functions and implications for neurodegeneration
FC Fiesel, PJ Kahle; FEBS J. 2011 Oct;278(19):3550-68. doi: 10.1111/j.1742-4658.2011.08258.x. Epub 2011 Aug 24.
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: A meta-analysis of genetic studies and randomised trials
MV Holmes, P Newcombe, JA Hubacek, R Sofat, SL Ricketts, J Cooper, MM Breteler, LE Bautista, P Sharma, JC Whittaker, L Smeeth, FGR Fowkes, A Algra, V Shmeleva, Z Szolnoki, M Roest, M Linnebank, J Zacho, MA Nalls, AB Singleton, L Ferrucci, J Hardy, BB Worrall, SS Rich, M Matarin, PE Norman, L Flicker, OP Almeida, FM Van Bockxmeer, H Shimokata, KT Khaw, NJ Wareham, M Bobak, JAC Sterne, GD Smith, PJ Talmud, C Van Duijn, SE Humphries, JF Price, S Ebrahim, DA Lawlor, GJ Hankey, JF Meschia, MS Sandhu, AD Hingorani, JP Casas; Lancet. 2011 Aug 13;378(9791):584-94. Epub 2011 Jul 29.
Net costs of dementia by disease stage
H Leicht, S Heinrich, D Heider, C Bachmann, H Bickel, H van den Bussche, A Fuchs, M Luppa, W Maier, E Mösch, M Pentzek, SG Rieder-Heller, F Tebarth, J Werle, S Weyerer, B Wiese, T Zimmermann, HH König; Acta Psychiatr Scand. 2011 Aug 13. doi: 10.1111/j.1600-0447.2011.01741.x. [Epub ahead of print]
Between promiscuity and specificity: Novel roles of EF-hand calcium sensors in neuronal Ca2+ signalling
M Mikhaylova, J Hradsky, MR Kreutz; J Neurochem. 2011 Sep;118(5):695-713. doi: 10.1111/j.1471-4159.2011.07372.x. Epub 2011 Jul 21.
Comparing quality of nutritional care in Dutch and German nursing homes
NC Van Nie-Visser, JM Meijers, JM Schols, C Lohrmann, S Bartholomeyczik, RJ Halfens; J Clin Nurs. 2011 Sep;20(17-18):2501-8. doi: 10.1111/j.1365-2702.2011.03761.x. Epub 2011 Jul 3.
Between promiscuity and specificity: Novel roles of EF-hand calcium sensors in neuronal Ca2+ signalling.
M Mikhaylova, J Hradsky, MR Kreutz, Journal of Neurochemistry, 2011 Sep, 118(5):695-713. doi: 10.1111/j.1471-4159.2011.07372.x. Epub ahead of print.
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.
MV Holmes, P Newcombe, JA Hubacek, R Sofat, SL Ricketts, J Cooper, MM Breteler, LE Bautista, P Sharma, JC Whittaker, L Smeeth, FGR Fowkes, A Algra, V Shmeleva, Z Szolnoki, M Roest, M Linnebank, J Zacho, MA Nalls, AB Singleton, L Ferrucci, J Hardy, BB Worrall, SS Rich, M Matarin, PE Norman, L Flicker, OP Almeida, FM van Bockxmeer, H Shimokata, K-T Khaw, NJ Wareham, M Bobak, JA Sterne, GD Smith, PJ Talmud, C van Duijn, SE Humphries, Price, J.F., Ebrahim, S., Lawlor, D.A., Hankey, G.J., Meschia, J.F., Sandhu, M.S., Hingorani, A.D., Casas, J.P., Lancet. 2011 Aug 13; 378(9791): 584-94. Epub 2011 Jul 29.
Longitudinal changes of fractial anisotropy in Alzheimer’s disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study.
Y Likitjaroen, T Meindl, U Friese,M Wagner, K Buerger, H Hampel, SJ Teipel, Eur Arch Psychiatry Clin Neurosci, 2011 Aug 5, Epub ahead of print.
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
J Araujo, P Breuer, S Dieringer, S Krauss, S Dorn, K Zimmermann, A Pfeifer, T Klockgether, U Wuellner, BO Evert, Human Molecular Genetics, 2011 Aug 1, 20 (15) art. no. ddr197, pp 2928-2941.
Update on degenerative ataxias.
T Klockgether. Curr Opin Neurol. 2011 Aug; 24(4):339-45.
Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.
O Azimzadeh, H Scherthan, H Sarioglu, Z Barjaktarovic, M Conrad, A Vogt, J Calzada-Wack, F Neff, M Aubele, C Buske, MJ Atkinson, S Tapio.Proteomics. 2011 Aug; 11(16):3299-311. doi: 10.1002/pmic.201100178.
The presymptomatic stage of neurodegenerative disorders. [Das präsymptomatische Stadium neurodegenerativer Erkrankungen.]
C Klein, J Hagenah, B Landwehrmeyer, T Münte, T Klockgether, Nervenarzt. 2011 Aug; 82(8):994-1001.
Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment.
P Schneider, K Buerger, S Teipel, O Uspenskaya, O Hartmann, O Hansson, L Minthon, D Rujescu, H-J Moeller, H Zetterberg, K Blennow, A Ernst, A Bergmann, H Hampel, Biological Psychiatry, 2011 Jul 15, 70 (2), pp. 145-151.
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.
LF Burbulla, R Krüger; J Neurol Sci. 2011 Jul 15;306(1-2):1-8. Epub 2011 Apr 21.
Effects of transient global ischaemia on freezing behaviour and activity in a context-dependent fear conditioning task - Implications for memory investigations.
P Henrich-Noack, K Krautwald, KG Reymann, W Wetzel, Brain Research Bulletin, 2011 Jul 15, 85(6), pp. 346-353.
Biomarker candidates of neurodegeneration in Parkinson's disease for the evaluation of disease-modifying therapeutics.
M Gerlach, W Maetzler, K Broich, H Hampel, L Rems, T Reum, P Riederer, A Stöffler, J Streffer, D Berg, Journal of Neural Transmission, 2011 Jul 14, pp. 1-14.
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
V Lazarevic, C Schöne, M Heine, ED Gundelfinger, A Fejtova, Journal of Neuroscience, 2011 Jul 13, 31 (28) pp.10189-10200.
N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant.
B Di Benedetto, R Kühn, C Nothdurfter, T Rein, W Wurst, R Rupprecht, Neuropharmacology, 2011 Jul 13, 118(5):695-713. doi: 10.1111/j.1471-4159.2011.07372.x. Epub.
The valence of action outcomes modulates the perception of one's actions.
C Wilke, M Synofzik, A Lindner; Conscious Cogn. 2011 Jul 12. [Epub ahead of print]
Tissue specific resonance frequencies of water and metabolites within the human brain.
GL Chadzynski, B Bender, A Groeger, M Erb, U Klose, Journal of Magnetic Resonance, 2011 Jul 11, [Article in Press].
Acetazolamide-responsive exercise-induced episodic ataxia associated with a novel homozygous DARS2 mutation.
M Synofzik, J Schicks, T Lindig, S Biskup, T Schmidt, J Hansel, F Lehmann-Horn, L Schöls; J Med Genet. 2011 Oct;48(10):713-5. Epub 2011 Jul 11.
Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy.
V Koppelmans, SB Schagen, MMF Poels, W Boogerd, C Seynaeve, Avd Lugt, MMB Breteler, European Journal of Cancer, 2011 Jul 9, [Article in Press].
Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice.
D Ehninger, LP Wang, F Klempin, B Römer, H Kettenmann, G Kempermann; Cell Tissue Res. 2011 Jul;345(1):69-86. Epub 2011 Jun 21.
Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering.
AV Shkumatov, S Chinnathambi, E Mandelkow, DI Svergun; Proteins. 2011 Jul;79(7):2122-31. doi: 10.1002/prot.23033. Epub 2011 May 10.
Structural and functional neuronal connectivity in Alzheimer's disease : A combined DTI and fMRI study.
J Soldner, T Meindl, W Koch, AL Bokde, MF Reiser, HJ Möller, K Bürger, H Hampel, SJ Teipel; Nervenarzt. 2011 Jun 30. [Epub ahead of print]
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
JC Fitzgerald, MD Camprubi, L Dunn, HC Wu, NY Ip, R Kruger, LM Martins, NW Wood, H Plun-Favreau; Cell Death Differ. 2011 Jun 24. doi: 10.1038/cdd.2011.90. [Epub ahead of print]
Isolated motor neglect following infarction of the posterior limb of the right internal capsule: a case study with diffusion tensor imaging-based tractography.
Y Likitjaroen, NC Suwanwela, AJ Mitchell, S Lerdlum, K Phanthumchinda, SJ Teipel; J Neurol. 2011 Jun 22. [Epub ahead of print]
Staging Alzheimer’s disease progression with multimodality neuroimaging.
M Ewers, GB Frisoni, SJ Teipel, LT Grinberg, E Jr. Amaro, H Heinsen, PM Thompson, H Hampel, Prog. Neurobiol, 2011 June 22, Epub ahead of print.
TDP-43 and FUS: a nuclear affair.
D Dormann, C Haass; Trends Neurosci. 2011 Jun 21. [Epub ahead of print]
Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase.
S Hogl, PH Kuhn, A Colombo, SF Lichtenthaler; PLoS One. 2011;6(6):e21337. Epub 2011 Jun 17.
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
GU Höglinger, NM Melhem, DW Dickson, PM Sleiman, LS Wang, L Klei, R Rademakers, R de Silva, I Litvan, DE Riley, JC van Swieten, P Heutink, ZK Wszolek, RJ Uitti, J Vandrovcova, HI Hurtig, RG Gross, W Maetzler, S Goldwurm, E Tolosa, B Borroni, P Pastor; PSP Genetics Study Group, RL Albin, E Alonso, A Antonini, M Apfelbacher, SE Arnold, J Avila, TG Beach, S Beecher, D Berg, TD Bird, N Bogdanovic, AJ Boon, Y Bordelon, A Brice, H Budka, M Canesi, WZ Chiu, R Cilia, C Colosimo, PP De Deyn, JG de Yebenes, LD Kaat, R Duara, A Durr, S Engelborghs, G Fabbrini, NA Finch, R Flook, MP Frosch, C Gaig, DR Galasko, T Gasser, M Gearing, ET Geller, B Ghetti, NR Graff-Radford, M Grossman, DA Hall, LN Hazrati, M Höllerhage, J Jankovic, JL Juncos, A Karydas, HA Kretzschmar, I Leber, VM Lee, AP Lieberman, KE Lyons, C Mariani, E Masliah, LA Massey, CA McLean, N Meucci, BL Miller, B Mollenhauer, JC Möller, HR Morris, C Morris, SS O'Sullivan, WH Oertel, D Ottaviani, A Padovani, R Pahwa, G Pezzoli, S Pickering-Brown, W Poewe, A Rabano, A Rajput, SG Reich, G Respondek, S Roeber, JD Rohrer, OA Ross, MN Rossor, G Sacilotto, WW Seeley, K Seppi, L Silveira-Moriyama, S Spina, K Srulijes, P St George-Hyslop, M Stamelou, DG Standaert, S Tesei, WW Tourtellotte, C Trenkwalder, C Troakes, JQ Trojanowski, JC Troncoso, VM Van Deerlin, JP Vonsattel, GK Wenning, CL White, P Winter, C Zarow, AL Zecchinelli, LB Cantwell, MR Han, A Dillman, MP van der Brug, JR Gibbs, MR Cookson, DG Hernandez, AB Singleton, MJ Farrer, CE Yu, LI Golbe, T Revesz, J Hardy, AJ Lees, B Devlin, H Hakonarson, U Müller, GD Schellenberg; Nat Genet. 2011 Jun 19;43(7):699-705. doi: 10.1038/ng.859.
Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease.
M Ewers, S Schmitz, O Hansson, C Walsh, A Fitzpatrick, D Bennett, L Minthon, JQ Trojanowski, LM Shaw, YO Faluyi, B Vellas, B Dubois, K Blennow, K Buerger, SJ Teipel, M Weiner, H Hampel, Alzheimer's Disease Neuroimaging Initiative; Neurobiol Aging. 2011 Jun 16. [Epub ahead of print]
Competing Interactions Stabilize Pro- and Anti-aggregant Conformations of Human Tau
Wegmann S, Schöler J, Bippes CA, Mandelkow E, Muller DJ, J Biol Chem. 2011 Jun 10;286(23):20512-24. Epub 2011 Apr 15.
AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials.
D Berg, J Godau, C Trenkwalder, K Eggert, I Csoti, A Storch, H Huber, M Morelli-Canelo, M Stamelou, V Ries, M Wolz, C Schneider, T Di Paolo, F Gasparini, S Hariry, M Vandemeulebroecke, W Abi-Saab, K Cooke, D Johns, B Gomez-Mancilla; Mov Disord. 2011 Jun;26(7):1243-50. doi: 10.1002/mds.23616. Epub 2011 Apr 11.
Spinocerebellar ataxia type 15: diagnostic assessment, frequency, and phenotypic features.
Synofzik M, Beetz C, Bauer C, Bonin M, Sanchez-Ferrero E, Schmitz-Hübsch T, Wüllner U, Nägele T, Riess O, Schöls L, Bauer P, J Med Genet. 2011 Jun;48(6):407-12. Epub 2011 Mar 1.
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing.
SF Lichtenthaler, C Haass, H Steiner; J Neurochem. 2011 Jun;117(5):779-96. doi: 10.1111/j.1471-4159.2011.07248.x. Epub 2011 Apr 14.
Performance-related increases in hippocampal N-acetylaspartate (NAA) induced by spatial navigation training are restricted to BDNF Val homozygotes
Lövdén M, Schaefer S, Noack H, Kanowski M, Kaufmann J, Tempelmann C, Bodammer NC, Kühn S, Heinze HJ, Lindenberger U, Düzel E, Bäckman L, Cereb Cortex. 2011 Jun;21(6):1435-42. Epub 2010 Nov 11.
Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice
Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J, J Biol Chem. 2011 May 27;286(21):18614-22. Epub 2011 Apr 5.
Milestones in PD genetics.
Gasser T, Hardy J, Mizuno Y, Mov Disord. 2011 May;26(6):1042-8. doi: 10.1002/mds.23637.
Milestones in magnetic resonance imaging and transcranial sonography of movement disorders.
Berg D, Steinberger JD, Warren Olanow C, Naidich TP, Yousry TA, Mov Disord. 2011 May;26(6):979-92. doi: 10.1002/mds.23766.
Milestones in ataxia
Klockgether T, Paulson H, Mov Disord. 2011 May;26(6):1134-41. doi: 10.1002/mds.23559.
Coupling electrophysiological and hemodynamic responses to errors.
Doñamayor N, Heilbronner U, Münte TF, Hum Brain Mapp. 2011 May 26. doi: 10.1002/hbm.21305. [Epub ahead of print]
Auditory event-related response in visual cortex modulates subsequent visual responses in humans
Naue N, Rach S, Strüber D, Huster RJ, Zaehle T, Körner U, Herrmann CS, J Neurosci. 2011 May 25;31(21):7729-36.
Control of mTORC1 signaling by the Opitz syndrome protein MID1.
Liu E, Knutzen CA, Krauss S, Schweiger S, Chiang GG, Proc Natl Acad Sci U S A. 2011 May 24;108(21):8680-5. Epub 2011 May 9
Long-Term Stability of Alzheimer's Disease Biomarker Proteins in Cerebrospinal Fluid.
CG Schipke, F Jessen, S Teipel, C Luckhaus, J Wiltfang, H Esselmann, L Frölich, W Maier, E Rüther, FL Heppner, S Prokop, I Heuser, O Peters; J Alzheimers Dis. 2011 May 23. [Epub ahead of print]
Visual personal familiarity in amnestic mild cognitive impairment.
Jurjanz L, Donix M, Amanatidis EC, Meyer S, Poettrich K, Huebner T, Baeumler D, Smolka MN, Holthoff VA, PLoS One. 2011;6(5):e20030. Epub 2011 May 20.
Neuroprotective and Neurotoxic Signaling by the Prion Protein.
UK Resenberger, KF Winklhofer, J. Tatzelt, Top Curr Chem. 2011 May 20. [Epub ahead of print]
Left Anterior Temporal Lobe Sustains Naming in Alzheimer's Dementia and Mild Cognitive Impairment.
L Frings, S Klöppel, S Teipel, O Peters, L Frölich, J Pantel, J Schröder, HJ Gertz, S Arlt, I Heuser, J Kornhuber, J Wiltfang, W Maier, F Jessen, H Hampel, M Hüll; Curr Alzheimer Res. 2011 May 18. [Epub ahead of print]
Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression.
SJ Teipel, R Buchert, J Thome, H Hampel, J Pahnke; Prog Neurobiol. 2011 May 12. [Epub ahead of print]
Hippocampal Theta-Phase Modulation of Replay Correlates with Configural-Relational Short-Term Memory Performance
Poch C, Fuentemilla L, Barnes GR, Düzel E, J Neurosci. 2011 May 11;31(19):7038-7042.
Zeitbedarf und Kosten für die Umsetzung eines Medikamentenreviews und assoziierter pharmazeutischer und medizinischer Evaluation im ambulanten Versorgungssektor.
T Fiß, M Schaefer, N van den Berg, W Hoffmann; Gesundheitswesen. 2011 May 11. [Epub ahead of print]
Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.
D Ehninger, AJ Silva; Behav Genet. 2011 May;41(3):357-63. doi: 10.1007/s10519-010-9398-1. Epub 2010 Sep 30.
Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease.
Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR, J Neural Transm. 2011 May;118(5):699-712. Epub 2011 Jan 6.
Stem cell-based therapies in Parkinson's disease: Future hope or current treatment option?
K Loewenbrück, A Storch, Journal of Neurology, 2011 May, 258 (suppl.2), pp. S346-S353.
Evidence-based therapeutic algorithms in the treatment of depression, dementia and psychosis in Parkinson's disease.
R Krüger, D Weiss, 2011 MMW-Fortschritte der Medizin, 153 (14) pp. 29-32.
Einführung und Evaluation der "Verstehenden Diagnostik" am Beispiel des Leuchtturmprojektes InDemA´.
D Hardenacke, S Bartholomeyczik, M Halek, Mai 2011, Pflege & Gesellschaft, 16 (2), 101-115.
Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays.
R Augustin, SF Lichtenthaler, M Greeff, J Hansen, W Wurst, D Trümbach; Int J Alzheimers Dis. 2011 Apr 26;2011:154325.
Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.
M. Lövdén, S. Schaefer, H. Noack, NC Bodammer, S. Kühn, HJ Heinze, E. Düzel, L. Bäckman, U. Lindenberger, Neurobiol Aging. 2011 Apr 15. [Epub ahead of print]
p73: a multifunctional protein in neurobiology.
R Killick, M Niklison-Chirou, R Tomasini, D Bano, A Rufini, F Grespi, T Velletri, P Tucci, BS Sayan, F Conforti, E Gallagher, P Nicotera, TW Mak, G Melino, RA Knight, M Agostini; Mol Neurobiol. 2011 Apr;43(2):139-46. Epub 2011 Mar 8.
Rita's 102!!
R Levi-Montalcini, RA Knight, P Nicotera, G Nisticó, N Bazan, G Melino; Mol Neurobiol. 2011 Apr;43(2):77-9.
Ageing, Neuronal Connectivity and Brain Disorders: An Unsolved Ripple Effect.
Bano D, Agostini M, Melino G, Nicotera P, Mol Neurobiol. 2011 Apr;43(2):124-30. Epub 2011 Jan 15.
p73: a multifunctional protein in neurobiology.
R Killick, M Niklison-Chirou, R Tomasini, D Bano, A Rufini, F Grespi, T Velletri, P Tucci, BS Sayan, F Conforti, E Gallagher, P Nicotera, TW Mak, G Melino, RA Knight, M Agostini; Mol Neurobiol. 2011 Apr;43(2):139-46. Epub 2011 Mar 8.
Conserved stress-protective activity between prion protein and Shadoo.
V. Sakthivelu, RP Seidel, KF Winklhofer, J. Tatzelt, J Biol Chem. 2011 Mar 18;286(11):8901-8. Epub 2011 Jan 21.
On the follow-up of genome-wide association studies: an overall test for the most promising SNPs
Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C, Genet Epidemiol. 2011 Jul;35(5):303-9. doi: 10.1002/gepi.20578. Epub 2011 Mar 3.
PPARy co-activator-1α (PGC-1α) reduces amyloid-ß generation through a PPARy-dependent mechanism.
L Katsouri, C Parr, N Bogdanovic, M Willem, M Sastre, Journal of Alzheimer's Disease, 2011 Feb 25, 25 (1), pp. 151-162.
Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons.
Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C, Cell Death Differ. 2011 Feb;18(2):282-92. Epub 2010 Aug 6.
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion.
I Hafner-Bratkovic, R Bester, P Pristovsek, L Gaedtke, P Veranic, J Gaspersic, M Mancek-Keber, M Avbelj, M Polymenidou, C Julius, A Aguzzi, I Vorberg, R Jerala;
J Biol Chem. 2011 Feb 15. [Epub ahead of print]
Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis.
Fischer T, Faus-Kessler T, Welzl G, Simeone A, Wurst W, Prakash N, Dev Biol. 2011 Feb 15;350(2):496-510. Epub 2010 Dec 21.
Inferring genetic causal effects on survival data with associated endo-phenotypes.
Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C, Genet Epidemiol. 2011 Feb;35(2):119-24. doi: 10.1002/gepi.20557. Epub 2010 Dec 31.
Resources for proteomics in mouse embryonic stem cells.
Schnütgen F, Ehrmann F, Poser I, Hubner NC, Hansen J, Floss T, Devries I, Wurst W, Hyman A, Mann M, Von Melchner H, Nat Methods. 2011 Feb;8(2):103-4.
Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH, Mol Cell Neurosci. 2011 Feb;46(2):419-31. Epub 2010 Nov 29.
Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.
A Capell, S Liebscher, K Fellerer, N Brouwers, M Willem, S Lammich, I Gijselinck, T Bittner, AM Carlson, F Sasse, B Kunze, H Steinmetz, R Jansen, D Dormann, K Sleegers, M Cruts, J Herms, C Van Broeckhoven, C Haass; J Neurosci. 2011 Feb 2.
Central oscillators in a patient with neuropathic tremor: Evidence from intraoperative local field potential recordings
Weiss D, Govindan RB, Rilk A, Wächter T, Breit S, Zizlsperger L, Haarmeier T, Plewnia C, Krüger R, Gharabaghi A., Mov Disord. 2011 Feb 1;26(2):323-7.
F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.
Peterziel H, Sackmann T, Strelau J, Kuhn PH, Lichtenthaler SF, Marom K, Klar A, Unsicker K, Mol Cell Neurosci. 2011 Feb;46(2):483-97. Epub 2010 Dec 9.
Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans.
C Roder, V Peters, H Kasuya, T Nishizawa, Y Takehara, D Berg, C Schulte, N Khan, M Tatagiba, B Krischek; Childs Nerv Syst. 2011 Feb; Epub 2010 Aug 6.
[Quality management in ambulatory care nursing and inpatient nursing in Germany. Specifics and current trends].
M Geraedts, B Holle, HC Vollmar, S Bartholomeyczik; Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011 Feb;54(2):185-93.
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.
Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, Glynn P, Cain K, Kyriacou CP, Giorgini F, Nicotera P, Cell Death Differ. 2011 Feb;18(2):191-200. Epub 2010 Nov 19.
"Das Altern entschlüsseln" Ausschnitte des BMBF-Foresight-Prozesses
Vollmar HC, Georgieff P, Cuhls K, Zeitschrift für Gerontologie und Geriatrie, Volume 44, Number 1, 66-70, DOI: 10.1007/s00391-010-0164-z
The role of additive neurogenesis and synaptic plasticity in a hippocampal memory model with grid-cell like input
Appleby PA, Kempermann G, Wiskott L, PLoS Comput Biol. 2011 Jan 27;7(1)
Mapping out biomarkers for Alzheimer disease.
Breteler MMB , JAMA. 2011 Jan 19;305(3):304-5.
Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans.
Schott BH, Seidenbecher CI, Richter S, Wüstenberg T, Debska-Vielhaber G, Schubert H, Heinze HJ, Richardson-Klavehn A, Düzel E, PLoS One. 2011 Jan 18;6(1):e15984
Relation of risk factors and putative premotor markers for Parkinson's disease.
Liepelt-Scarfone I, Behnke S, Godau J, Schweitzer KJ, Wolf B, Gaenslen A, Berg D, J Neural Transm. 2011 Apr;118(4):579-85. Epub 2011 Jan 6.
Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence
Zaehle T, Sandmann P, Thorne JD, Jäncke L, Herrmann CS, BMC Neurosci. 2011 Jan 6;12:2.
Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.
B Schürmann, B Wiese, H Bickel, S Weyerer, SG Riedel-Heller, M Pentzek, C Bachmann, J Williams, H van den Bussche, W Maier, F Jessen. Journal of Alzheimer's Disease, 2011;25(3):421-4.
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, Riemenschneider M, Owen M, Harold D, Hollingworth P, Cellini E, Sorbi S, Nacmias B, Takeda M, Pericak-Vance MA, Haines JL, Younkin S, Williams J, Van Broeckhoven C, Farrer LA, St George-Hyslop PH, Mayeux R, Arch Neurol. 2011 Jan;68(1):99-106.
Cell death mechanisms and their implications in toxicology.
Orrenius S, Nicotera P, Zhivotovsky B, Toxicol Sci. 2011 Jan;119(1):3-19. Epub 2010 Sep 9.
Alpha-secretase in Alzheimer's disease: Molecular identity, regulation and therapeutic potential.
Lichtenthaler SF, J Neurochem. 2011 Jan;116(1):10-21. doi: 10.1111/j.1471-4159.2010.07081.x. Epub 2010 Dec 2.
ADAM10: Potential 'molecular scissors for the treatment of Alzheimers disease.
Lichtenthaler SF, Future Neurology January 2011, Vol. 6, No. 1, Pages 1-4 , DOI 10.2217/fnl.10.75
Neural synchrony and white matter variations in the human brain-Relation between evoked gamma frequency and corpus callosum morphology.
T Zaehle, CS Herrmann; Int J Psychophysiol. 2011 Jan.
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.
S Garg, T Timm, EM Mandelkow, E Mandelkow, Y Wang; Neurobiol Aging. 2011 Jan;32(1):1-14. Epub 2010 Oct 18.
Increased CSF-BACE1 activity associated with decreased hippocampus volume in Alzheimer's disease.
M Ewers, HF Nural, C Walsh, T Meindl, SJ Teipel, K Buerger, P He, Y Shen, H Hampel, Journal of Alzheimer's Disease, 2011 25 (2) pp. 373-381.
Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
Dislich B, Than ME, Lichtenthaler SF, Biochem J. 2010 Dec 15;433(1):75-83.
Why and how physical activity experience-induced brain plasticity.
G Kempermann, K Fabel, D Ehninger, H Babu, P Leal-Galicia, A Garthe, SA Wolf; Front Neurosci. 2010 Dec 8;
Blended Learning zur hausärztlichen Demenz-Fortbildung: Einschätzung durch Nutzer einer cluster-randomisierten Studie
HC Vollmar, H Mayer, S Wilm, MA Rieger, T Ostermann; GMS Med Inform Biom Epidemiol 2010;6(2):Doc06
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.
M Di Salvio, LG Di Giovannantonio, D Acampora, R Prosperi, D Omodei, N Prakash, W Wurst, A Simeone; Nat Neurosci. 2010 Dec;13(12):1481-8. Epub 2010 Nov 7.
Correspondence (letter to the editor):Definition of age.
T Fiss, W Hoffmann; Dtsch Arztebl Int. 2010 Dec;107(50):899-900. Epub 2010 Dec 17.
[Health services research project "action alliance pain-free city Münster" : Objectives and methods].
J Osterbrink, A Ewers, N Nestler, E Pogatzki-Zahn, Z Bauer, I Gnass, E Sirsch, C Krüger, B Mitterlehner, P Kutschar, S Hemling, B Fischer, U Marschall, W Aschauer, M Weichbold, H van Aken; Schmerz. 2010 Dec;24(6):613-20.
Age and the neural network of personal familiarity.
M Donix, K Petrowski, L Jurjanz, T Huebner, U Herold, D Baeumler, EC Amanatidis, K Poettrich, MN Smolka, VA Holthoff; PLoS One. 2010 Dec 22;5(12):e15790.
Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
E Ziviani, G Lippi, D Bano, E Munarriz, S Guiducci, M Zoli, KW Young, P Nicotera; EMBO Journal. 2010 Nov 26; doi: EMBOJ.2010.279
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
L Bouman, A Schlierf, AK Lutz, J Shan, A Deinlein, J Kast, Z Galehdar, V Palmisano, N Patenge, D Berg, T Gasser, R Augustin, D Trümbach, I Irrcher, DS Park, W Wurst, MS Kilberg, J Tatzelt, KF Winklhofer; Cell Death Differ., 18, 769-782, Epub 2010 Nov 26.
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
E Kickstein, S Krauss, P Thornhill, D Rutschow, R Zeller, J Sharkey, R Williamson, M Fuchs, A Köhler, H Glossmann, R Schneider, C Sutherland, S Schweiger; PNAS. 2010 Nov 22; doi:10.1073/pnas.0912793107
A tool to improve pre-selection for deep brain stimulation in patients with Parkinson's disease.
T Wächter, A Mínguez-Castellanos, F Valldeoriola, J Herzog, H Stoevelaar; J Neurol. 2010 Nov 19. [Epub ahead of print]
A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of CA (v)2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons.
JY Park, S Remy, J Varela, DC Cooper, S Chung, HW Kang, JH Lee, N Spruston; PLoS Biol. 2010 Nov 16; 8(11):e1000534.
POLG, but not PEO1, is a frequent cause of cerebellar ataxia in Central Europe.
J. Schicks, M. Synofzik, C. Schulte, L. Schöls, Mov Disord. 2010 Nov 15;25(15):2678-82.
Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice.
D Ehninger, Y Sano, P J de Vries, K Dies, D Franz, D H Geschwind, M Kaur, Y-S Lee, W Li, J K Lowe, J A Nakagawa, M Sahin, K Smith, V Whittemore, A J Silva; Molecular Psychiatry. 2010 Nov 16
Callosal tissue loss in multiple system atrophy-A one-year follow-up study.
M Minnerop, E Lüders, K Specht, J Ruhlmann, N Schimke, PM Thompson, YY Chou, AW Toga, M Abele, U Wüllner, T Klockgether; Mov Disord. 2010 Nov 15.
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: Functional impact of disease-related variants on mitochondrial homeostasis.
LF Burbulla, C Schelling, H Kato, D Rapaport, D Woitalla, C Schiesling, C Schulte, M Sharma, T Illig, P Bauer, S Jung, A Nordheim, L Schöls, O Riess, R Krüger; Hum Mol Genet. 2010 Nov 15;19(22):4437-52. Epub 2010 Sep 2.
Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.
PK Mandal, M Schneider, P Kölle, P Kuhlencordt, H Förster, H Beck, GW Bornkamm, M Conrad; Cancer Res. 2010 Nov 15;70(22):9505-14. Epub 2010 Nov 2.
Performance-Related Increases in Hippocampal N-acetylaspartate (NAA) Induced by Spatial Navigation Training Are Restricted to BDNF Val Homozygotes.
M. Lövdén, S. Schaefer, H. Noack, M. Kanowski, J. Kaufmann, C. Tempelmann, NC Bodammer, S. Kühn, HJ Heinze, U. Lindenberger, E. Düzel, L. Bäckman, Cereb Cortex. 2011 Jun;21(6):1435-42. Epub 2010 Nov 11.
Combining independent drug classes into superior, synergistically acting hybrid molecules.
A Müller-Schiffmann, J März-Berberich, A Andreyeva, R Rönicke, D Bartnik, O Brener, J Kutzsche, AH Horn, M Hellmert, J Polkowska, K Gottmann, KG Reymann, SA Funke, L Nagel-Steger, C Moriscot, G Schoehn, H Sticht, D Willbold, T Schrader, C Korth; Angew Chem Int Ed Engl. 2010 Nov 8.
Microglia activation is related to substantia nigra echogenicity.
D. Berg, J. Godau, P. Riederer, M. Gerlach, T. Arzberger, J Neural Transm. 2010 Nov;117(11):1287-92. Epub 2010 Nov 6.
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
D Ehninger, A J Silva; Trends in Molecular Medicine. 2010 Nov 5
Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
T Zaehle, S Rach, CS Herrmann; PLoS One. 2010 Nov 1.
Spinocerebellar ataxia type 11 (SCA11) is an uncommon cause of dominant ataxia among French and German kindreds.
P Bauer, G Stevanin, C Beetz, M Synofzik, T Schmitz-Hübsch, U Wüllner, E Berthier, E Ollagnon-Roman, O Riess, S Forlani, E Mundwiller, A Durr, L Schöls, A Brice; J Neurol Neurosurg Psychiatry. 2010 Nov;81(11):1229-32. Epub 2010 Jul 28.
Balance is the challenge - The impact of mitochondrial dynamics in Parkinson's disease.
LF Burbulla, G Krebiehl, R Krüger; Eur J Clin Invest. 2010 Nov.
Experience-dependent plasticity of white-matter microstructure extends into old age.
M Lövdén, NC Bodammer, S Kühn, J Kaufmann, H Schütze, C Tempelmann, HJ Heinze, E Düzel, F Schmiedek, U Lindenberger; Neuropsychologia. 2010 Nov;48(13):3878-83. Epub 2010 Sep 15.
Testing for non-random mating: Evidence for ancestry-related assortative mating in the Framingham heart study.
R Sebro, TJ Hoffman, C Lange, JJ Rogus, NJ Risch; Genet Epidemiol. 2010 Nov.
Initiation and propagation of neurodegeneration.
C. Haass; Nat Med. 2010 Nov.
Boxing-acute complications and late sequelae: from concussion to dementia.
H Förstl, C Haass, B Hemmer, B Meyer, M Halle; Dtsch Arztebl Int. 2010 Nov.
Complex hyperkinetic movement disorders associated with POLG mutations.
M. Synofzik, R. Schüle, C. Schulte, R. Krüger, T. Lindig, L. Schöls, F. Asmus, Mov Disord. 2010 Oct 30;25(14):2472-5.
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2.
K Haebig, CJ Gloeckner, MG Miralles, F Gillardon, C Schulte, O Riess, M Ueffing, S Biskup, M Bonin; PLoS One. 2010 Oct 29.
Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia.
SA Wolf, A Melnik, G Kempermann; Brain Behav Immun. 2010 Oct 21. [Epub ahead of print]
Early onset amyloid lesions lead to servere neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice.
NJ Rupp, BM Wegenast-Braun, R Radde, ME Calhoun, M Jucker; Neurobiol Aging. 2010 Oct 21. [Epub ahead of print]
Peripherally Applied A{beta}-Containing Inoculates Induce Cerebral {beta}-Amyloidosis.
YS Eisele, U Obermüller, G Heilbronner, F Baumann, SA Kaeser, H Wolburg, LC Walker, M Staufenbiel, M Heikenwalder, M Jucker; Science. 2010 Oct 21. [Epub ahead of print]
Automated detection of amyloid-beta-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI.
SJ Teipel, E Kaza, S Hadlich, A Bauer, T Brüning, AS Plath, M Krohn, K Scheffler, LC Walker, M Lotze, J Pahnke; J Alzheimers Dis. 2010 Oct 20.
Analysis of ACTA2 in European Moyamoya disease patients.
C Roder, V Peters, H Kasuya, T Nishizawa, S Wakita, D Berg, C Schulte, N Khan, M Tatagiba, B Krischek; Eur J Paediatr Neurol. 2010 Oct 20. [Epub ahead of print]
Significance Levels in Genome-Wide Interaction Analysis (GWIA).
Becker T, Herold C, Meesters C, Mattheisen M, Baur MP, Ann Hum Genet. 2011 Jan;75(1):29-35. doi: 10.1111/j.1469-1809.2010.00610.x. Epub 2010 Oct 18.
A large genome scan for rare CNVs in amyotrophic lateral sclerosis.
HM Blauw, A Al-Chalabi, PM Andersen, PW van Vught, FP Diekstra, MA van Es, CG Saris, EJ Groen, W van Rheenen, M Koppers, Rv Slot, E Strengman, K Estrada, F Rivadeneira, A Hofman, AG Uitterlinden, LA Kiemeney, SH Vermeulen, A Birve, S Waibel, T Meyer, S Cronin, RL McLaughlin, O hardiman, PC Sapp, MD Tobin, LV Wain, B Tomik, A Slowik, R Lemmens, D Rujescu, C Schulte, T Gasser, RH Brown Jr., JE Landers, W Robberecht, AC Ludolph, RA Ophoff, JH Veldink, LH van den Berg; Hum Mol Genet. 2010 Oct 15; Epub 2010 Aug 4.
Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism.
M Donix, AC Burggren, NA Suthana, P Siddarth, AD Ekstrom, AK Krupa, M Jones, A Rao, L Martin-Harris, LM Ercoli, KJ Miller, GW Small, SY Bookheimer; Neuroimage. 2010 Oct 15, Epub 2010 Jun 10.
Home-based music therapy - A systematic overview of settings and conditions for an innovative service in healthcare.
W Schmid, T Ostermann; BMC Health Serv Res. 2010 Oct 14.
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition.
M Guthoff, O Tschritter, D Berg, I Liepelt, C Schulte, F Machicao, H Breer, H-U Haering, A Fritsche; Int J Obes (Lond). 2010 Oct 12.
Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including Amyloid beta Precursor Protein.
A Tsolakidou, L Czibere, B Pütz, D Trümbach, M Panhuysen, JM Deussing, W Wurst, I Sillaber, R Landgraf, F Holsboer, T Rein; BMC Genomics. 2010 Oct 8.
The Belgian Nursing Minimum Data Set II (B-NMDS II) and its transfer to German hospitals: results of the first investigation phase, the translation and adaption process of the instrument
I Eberl, S Bartholomeyczik; Pflege. 2010 Oct.
Developments of nursing research within German-speaking countries - publications from 1988 until 2007 in the journal "Pflege".
E Hausner, M Halek, S Bartholomeyczik; Pflege. 2010 Oct.
Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing.
NK Chu, D Olschewski, R Seidel, KF Winkelhofer, J Tatzelt, M Engelhard, CFW Becker; J Pept Sci. 2010 Oct.
The benefits and limitations of animal models for translational research in neurodegenerative diseases.
M. Jucker, Nat Med. 2010 Nov;16(11):1210-4. Epub 2010 Sep 21.
Improvement of balance after audio-biofeedback. A 6-week intervention study in patients with progressive supranuclear palsy.
S. Nicolai, A. Mirelman, T. Herman, A. Zijlstra, M. Mancini, C. Becker, U. Lindemann, D. Berg, W. Maetzler, Z Gerontol Geriatr. 2010 Aug;43(4):224-8
Place value of transcranial sonography in early diagnosis of Parkinson's disease.
D. Berg, A. Gaenslen, Neurodegener Dis. 2010;7(5):291-9. Epub 2010 Jul 9.
Polymorphisms in TGFB1 and PDGFRB are associated with Moyamoya disease in European patients.
Roder C, Peters V, Kasuya H, Nishizawa T, Takehara Y, Berg D, Schulte C, Khan N, Tatagiba M, Krischek B., Acta Neurochir (Wien). 2010 Dec;152(12):2153-60. Epub 2010 Jun 23.
Involuntary eyelid closure after STN-DBS: evidence for different pathophysiological entities.
D. Weiss, T. Wächter, S. Breit, SN Jacob, JK Pomper, F. Asmus, J. Valls-Solé, C. Plewnia, T. Gasser, A. Gharabaghi, R. Krüger, J Neurol Neurosurg Psychiatry. 2010 Sep;81(9):1002-7. Epub 2010 Jun 20.
Progressive secondary neurodegeneration and microcalcification co-occur in osteopontin-deficient mice.
W. Maetzler, D. Berg, C. Funke, F. Sandmann, H. Stünitz, C. Maetzler, C. Nitsch, Am J Pathol. 2010 Aug;177(2):829-39. Epub 2010 Jun 3.
Severe orthostatic dysregulation associated with Wolfram syndrome.
M. Synofzik, D. Weiss, J. Erharhaghen, R. Krüger, L. Schöls, J Neurol. 2010 Oct;257(10):1751-3. Epub 2010 May 19.
A total of 220 patients with autosomal dominant spastic paraplegia do not display mutations in the SLC33A1 gene (SPG42).
NA Schlipf, C. Beetz, R. Schüle, G. Stevanin, AK Erichsen, S. Forlani, C. Zaros, K. Karle, S. Klebe, S. Klimpe, A. Durr, S. Otto, CM Tallaksen, O. Riess, A. Brice, P. Bauer, L. Schöls, Eur J Hum Genet. 2010 Sep;18(9):1065-7. Epub 2010 May 12.
Diffusion tensor imaging of the corpus callosum differentiates corticobasal Syndrome from Parkinson's disease.
K. Boelmans, NC Bodammer,B. Suchorska, J. Kaufmann, G. Ebersbach, HJ Heinze, L. Niehaus, Parkinsonism Relat Disord. 2010 Sep;16(8):498-502. Epub 2010 Jun 22.
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.
F Kamp, N Exner, AK Lutz, N Wender,J Hegermann, B Brunner, B Nuscher, T bartels, A Giese, K Beyer, S Eimer, KF Winklhofer, C Haass; EMBO J. 2010 Sep 14.
Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.
T Fiskerstrand, D H'Mida-Ben Brahim, S Johansson, A M'Zahem, BI Haukanes, N Drouot, J Zimmermann, AJ Cole, C Vedeler, C Bredrup, M Assoum, M Tazir, T Klockgether, A Hamri, VM Steen, H Boman, LA Bindoff, M Koenig, PM Knappskog; Am J Hum Genet. 2010 Sep 10.
Hyperechogenicity of the substantia nigra: pitfalls in assessment and specificity for Parkinson's disease.
D Berg; J Neural Transm. 2010 Sep 10.
Abeta oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.
H Zempel, E Thies, E mandelkow, E-M Mandelkow; J Neurosci. 2010 Sep 8.
12/15-Lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
M Conrad, A Sandin, H Förster, A Seiler, J Frijhoff, M Dagnell, GW Bornkamm, O Radmark, RH Van Huijsduijnen, P Aspenström, F Böhmer, A Östman; Proc Natl Acad Sci USA, 2010 Sep 7.
A Bayesian approach to genetic association studies with family-based designs.
MG Naylor, ST weiss, C Lange; Genet Epidemiol. 2010 Sep.
Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons.
KW Young, LGP Pinon, ETW Bampton, P Nicotera; J Biochem Mol Toxicol. 2010 Sep.
On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples.
A Murphy, S Won, A Rogers, JH Chu, BA Raby, C Lange; Genet Epidemiol. 2010 Sep.
A Bayesian approach to genetic association studies with family-based designs.
MG Naylor, ST Weiss, C Lange; Genet Epidemiol. 2010 Sep.
A common mechanism for adaptive scaling of reward and novelty.
N Bunzeck, P Dayan, RJ Dolan, E Duzel; Hum Brain Mapp. 2010 Sep.
Brain Areas Consistently Linked to Individual Differences in Perceptual Decision-making in Younger as well as Older Adults before and after Training.
S. Kühn, F. Schmiedek, B. Schott, R. Ratcliff, HJ Heinze, E. Düzel, U. Lindenberger, M. Lövden, J Cogn Neurosci. 2010 Aug 31. [Epub ahead of print]
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.
M Meyer, MH De Angelis, W Wurst, R Kühn; Proc Natl Acad Sci USA. 2010 Aug 24; Epub 2010 Aug 4.
Human tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability.
S Wegmann, JJ Yu, S Chinnathambi, E-M Mandelkow, E Mandelkow, DJ Muller; J Biol Chem. 2010 Aug 27, Epub 2010 Jun 21.
TDP-43-mediated neuron loss In Vivo requires RNA-binding activity.
A Voigt, D Herholz, FC Fiesel, K Kaur, D Müller, P Karsten, SS Weber, PJ Kahle, T Marquardt, JB Schulz; PloS One. 2010 Aug 18.
Versorgungsnahe Demenzforschung ermöglichen - Fragestellungen im Deutschen Zentrum für Neurodegenerative Erkrankungen an der Universität Witten/Herdecke
S Bartholomeyczik, B Holle, C Riesner, M Halek, HC Vollmar; Zeitschrift für Evidenz. 13. August 2010.
α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
AL McCormack, SK Mak, JM Henderson, D Bumcrot, MJ Farrer, DA Di Monte; PLoS ONE. 2010 Aug 11;5(8): e12122.
Fyn-tau-amyloid: a toxic triad.
C Haass, E Mandelkow; Cell. 2010 Aug 6;142(3):356-8.
Plasticity of voltage-gated ion channels in pyramidal cell dendrites
S Remy, H Beck, Y Yaari; Curr Opin Neurobiol. 2010 Aug 4. [Epub ahead of print]
Changing maternity leave policy: Short-term effects on fertility rates and demographic variables in Germany.
JR Thyrian, K Fendrich, A Lange, JP Haas, M Zygmunt, W Hoffmann; Soc Sci Med. 2010 Aug.
Commentary: Genetic news between ventricle and nose (Commentary on Poon et al.).
G Kempermann; Eur J Neurosci. 2010 Aug;32(4):521-2.
Combined application of the International Classification of Functioning, Disability and Health and the NANDA-International Taxonomy II.
C Boldt, E Grill, S Bartholomeyczik, M Brach, A Rauch, I Eriks-Hoogland, G Stucki; J Adv Nurs. 2010 Aug, Epub 2010 Jun 16.
Over-expression of alpha-synuclein in the nervous sytem enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.
H Siebert, PJ Kahle, ML Kramer, T Isik, OM Schlüter, WJ Schulz-Schaeffer, W Brück; J Neurochem. 2010 Aug.
The relation of regional cerebral perfusion and atrophy in mild cognitive imperment (MCI) and early Alzheimer's dementia.
C Luckhaus, M Cohnen, MO Fluss, M Janner, B Grass-Kapanke, SJ Teipel, M Grothe, H Hampel, O Peters, J Kornhuber, W Maier, T Supprian, W Gaebel, U Modder, HJ Wittsack; Psychiatry Res. 2010 Jul 30; 183(1): 44-51.
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons.
PH Kuhn, H Wang, B Dislich, A Colombo, U Zeitschel, JW Ellwart, E Kremmer, S Roßner, SF Lichtenthaler; EMBO J. 2010 Jul 30. [Epub ahead of print]
Parkin is protective against proteotoxic stress in a transgenic zebrafish model
ME Fett, A Pilsl, D Paquet, F van Bebber, C Haass, J Tatzelt, B Schmid, KF Winklhofer; PloS One. 2010 Jul 30.
The cholinergic system in mild cognitive impairment and Alzheimer's disease: An in vivo MRI and DTI study.
SJ Teipel, T Meindl, L Grinberg, M Grothe, JL Cantero, MF Reiser, HJ Möller, H Heinsen, H Hampel; Hum Brain mapp. 2010 Jul 29.
Keeping memory clear and stable-The contribution of human basal ganglia and prefrontal cortex to working memory.
B Baier, HO Karnath, M Dieterich, F Birklein, C Heinze, NG Müller; J Neurosci. 2010 Jul 21.
Pharmacotherapy of elderly patients in everyday anthroposophic medical practice: A prospective, multicenter observational study.
E Jeschke, T Ostermann, M Tabali, HC Vollmar, M Kröz, A Bockelbrink, CM Witt, SN Willich, H Matthes; BMC Geriatr. 2010 Jul 21.
Functional phenotyping of successful aging in long-term memory: Preserved performance in the absence of neural compensation.
E. Düzel, H. Schütze, AP Yonelinas, HJ Heinze. Hippocampus. 2010 Jul 21. [Epub ahead of print]
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives.
H Hampel, R Frank, K Broich, SJ Teipel, RG Katz, J Hardy, K Herholz, AL Bokde, F Jessen, YC Hoessler, WR Sanhai, H Zetterberg, J Woodcock, K Blennow; Nat Rev Drug Discov. 2010 July; 9(7): 560-74
Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation.
G von Wolff, C Avrabos, J Stepan, W Wurst, JM Deussing, F Holsboer, M Eder; J Psychiatr Res. 2010 Jul 7. [Epub ahead of print]
Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.
JM Deussing, J Breu, C Kühne, M Kallnik, M Bunck, L Glasl, YC Yen, MV Schmidt, R Zurmühlen, AM Vogl, V Gailus-Durner, H Fuchs, SM Hölter, CT Wotjak, R Landgraf, MH de Angelis, F Holsboer, W Wurst; J Neurosci. 2010 Jul 7; 30(27): 9103-16.
open PubMed Abstract
Phenotypic annotation of the mouse X chromosome.
BJ Cox, M Vollmer, O Tamplin, M Lu, S Biechele, M Gertsenstein, C van Campenhout, T Floss, R Kühn, W Wurst, H Lickert, J Rossant; Genome Res. 2010 Jul 6. [Epub ahead of print]
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
M Roffé, FH Beraldo, R Bester, M Nunziante, C Bach, G Mancini, S Gilch, I Vorberg, BA Castilho, VR Martins, GN Hajj; Proc Natl Acad Sci USA. 2010 Jul 20;107(29): 13147-52. Epub 2010 Jul 6.
Paraquat and Parkinson's disease.
C Berry, C La Vecchia, P Nicotera; Cell Death Differ. 2010 Jul; 17(7): 1115-25. Epub 2010 Jan 22.
open PubMed Abstract
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
D Dormann, R Rodde, D Edbauer, E Bentmann, I Fischer, A Hruscha, ME Than, IR Mackenzie, A Capell, B Schmid, M Neumann, C Haass; EMBO J. 2010 Jul 6. [Epub ahead of print]
The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.
S Ullrich, A Münch, S Neumann, E Kremmer, J Tatzelt, SF Lichtenthaler; J Biol Chem. 2010 Jul 2; 285(27): 20664-74. Epub 2010 Apr 28.
open PubMed Abstract
Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway.
M Malnar, M Kosicek, S Mitterreiter, D Omerbasic, SF Lichtenthaler, A Goate, S Hecimovic; Biochim Biophys Acta. 2010 July - August; 1802(7-8): 682-691. Epub 2010 May 20.
Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease.
SJ Teipel, M Ewers, S Wolf, F Jessen, H Kölsch, S Arlt, C Luckhaus, P Schönknecht, K Schmidtke, I Heuser, L Frölich, G Ende, J Pantel, J Wiltfang, F Rakebrandt, O Peters, C Born, J Kornhuber, H Hampel; Psychiatry Res. 2010 Jun 30; 182(3):244-50. Epub 2010 May 20.
Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease beta- and gamma-Secretase via Distinct Mechanisms.
S Mitterreiter, RM Page, F Kamp, J Hopson, E Winkler, HR Ha, R Hamid, J Herms, TU Mayer, DJ Nelson, H Steiner, T Stahl, U Zeitschel, S Rossner, C Haass, SF Lichtenthaler; J. Neurosci. 2010 Jun 30; 30(26): 8974–83.
Synthesis of a GPI anchor module suitable for protein post-translational modification.
MC Schumacher, U Resenberger, RP Seidel, CF Becker, KF Winklhofer, D Oesterhelt, J Tatzelt, M Engelhard; Biopolymers. 2010; 94(4): 457-64.
Neural synchrony and white matter variations in the human brain-Relation between evoked gamma frequency and corpus callosum morphology.
T Zaehle, CS Herrmann; Int J Psychophysiol. 2010 Jun 22.
MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
H Farhan, MW Wendeler, S Mitrovic, E Fava, Y Silberberg, R Sharan, M Zerial, HP Hauri; J CellBiol. 2010 Jun 14.
Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease.
W Koch, S Teipel, S Mueller, J Benninghoff, M Wagner, AL Bokde, H Hampel, U Coates, M Reider, T Meindl; Neurobiol Aging. 2010 Jun 10.
The transmembrane protein 147 (TMEM147) is a novel component of the nicalin-nomo protein complex.
U Dettmer, PH Kuhn, C Abou-Ajram, SF Lichtenthaler, M Krueger, E Kremmer, C Haass, C Haffner; J Biol Chem. 2010 Jun 10. [Epub ahead of print]
Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
A Fukumori, R Fluhrer, H Steiner, C Haass; J Neurosci. 2010 Jun 9; 30(23): 7853-62.
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
RM Page, A Gutsmiedl, A Fukumori, E Winkler, C Haass, H Steiner; J Biol Chem. 2010 Jun 4; 285(23): 17798-810. Epub 2010 Mar 26.
Resonance phenomena in the human auditory cortex: individual resonance frequencies of the cerebral cortex determine electrophysiological responses.
T Zaehle, D Lenz, FW Ohl, CS Herrmann; Ex Brain Res. 2010 Jun. Epub 2010 May 7.
An overview of 45 published database resources for complementary and alternative medicine.
K Boehm, C Raak, HC Vollmar, T Ostermann; Health Info Libr J. 2010 Jun.
Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.
KW Young, LG Piñón, D Dhiraj, D Twiddy, M Macfarlane, J Hickman, P Nicotera; Neuropharmacology. 2010 Jun.
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.
S Lammich, D Buell, S Zilow, AK Ludwig, B Nuscher, SF Lichtenthaler, C Prinzen, F Fahrenholz, C Haass; J Biol Chem. 2010 May 21; 285(21): 15753-60. Epub 2010 Mar 26.
open PubMed Abstract
Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.
N Höttecke, M Liebeck, K Baumann, R Schubenel, E Winkler, H Steiner, B Schmidt; Bioorg Med Chem Lett. 2010 May 1; 20(9): 2958-63. Epub 2010 Mar 4.
Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.
S Bartesaghi, J Betts-Henderson, K Cain, D Dinsdale, X Zhou, A Karlsson, P Salomoni, P Nicotera; Hum Mol Genet. 2010 May 1;19(9):1669-77. Epub 2010 Feb 1.
Expression profiling in peripheral blood reveals signature for penetrance in DYT1 dystonia.
M Walter, M Bonin, RS Pullman, EM Valente, M Loi, M Gambarin, D Raymond, M Tinazzi, C Kamm, N Glöckle, S Poths, T Gasser, SB Bressman, C Klein, LJ Ozelius, O Riess, K Grundmann; Neurobiol Dis. 2010 May, Epub 2010 Jan 4.
Visuohaptic convergence in a corticocerebellar network.
MJ Naumer, L Ratz, Y Yalachkov, A Polony, O Doehrmann, V Van De Ven, NG Müller, J Kaiser, G Hein; Eur J Neurosci. 2010 May.
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
J Coomaraswamy, E Kilger, H Wölfing, C Schäfer, SA Kaeser, BM Wegenast-Braun, JK Hefendehl, H Wolburg, M Mazzella, J Ghiso, M Goedert, H Akiyama, F Garcia-Sierra, DP Wolfer, PM Mathews, M Jucker; Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17): 7969-74. Epub 2010 Apr 12.
Theta-Coupled Periodic Replay in Working Memory.
L Fuentemilla, WD Penny, N Cashdollar, N Bunzeck, E Düzel; Curr Biol. 2010 Apr 13, Epub 2010 Mar 18.
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in Zebrafish.
F van Bebber, D Paquet, A Hruscha, B Schmid, C Haass; Neurobiol Dis. 2010 Apr 7. [Epub ahead of print]
DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.
TT Pham, F Giesert, A Röthig, T Floss, M Kallnik, K Weindl, SM Hölter, U Ahting, H Prokisch, L Becker, T Klopstock, M Hrabé de Angelis, K Beyer, K Görner, PJ Kahle, DM Vogt Weisenhorn, W Wurst; Genes Brain Behav. 2010 Apr; 9(3): 305-17. Epub 2009 Dec 17.
NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging.
E Düzel, N Bunzeck, M Guitart-Masip, S Düzel; Neurosci Biobehav Rev. 2010 Apr 3, Epub 2009 Aug 26.
The blind, the lame, and the poor signals of brain function-A comment on Sirotin and Das (2009).
A Kleinschmidt, NG Müller; Neuroimage. 2010 Apr 1.
Prediction of Dementia by Subjective Memory Impairment: effects of severity and temporal association with cognitive impairment.
F Jessen, B Wiese, C Bachmann, S Eifflaender-Gorfer, F Haller, H Koelsch, T Luck, E Moesch, H van den Bussche, M Wagner, A Wollny, T Zimmermann, M Pentzek, SG Riedel-Heller, HP Romberg, S Weyerer, H Kaduszkiewicz, W Maier, H Bickel, German Study on Aging, Cognition and Dementia in Primary Care Patients Study Group; Arch Gen Psychiatry. 2010 Apr; 67(4): 414-422.
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.
M Fuhrmann, T Bittner, CK Jung, S Burgold, RM Page, G Mitteregger, C Haass, FM Laferla, H Kretzschmar, J Herms; Nat Neurosci. 2010 Apr;13(4):411-3. Epub 2010 Mar 21.
Feasible and Successful: Genome-Wide Interaction Analysis Involving All 1.9 x 1011 Pair-Wise Interaction Tests
M Steffens, T Becker, T Sander, R Fimmers, C Herold, DA Holler, C Leu, S Herms, S Cichon, B Bohn, T Gerstner, M Griebel, MM Nöthen, TF Wienker, MP Baur; Hum Hered. 2010 Mar 31; 69(4): 268-284. [Epub ahead of print]
APP mutants respond to {gamma}-secretase modulators.
Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H.; J Biol Chem. 2010 Mar 26. [Epub ahead of print]
miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro.
H Chen, R Shalom-Feuerstein, J Riley, SD Zhang, P Tucci, M Agostini, D Aberdam, RA Knight, G Genchi, P Nicotera, G Melino, M Vasa-Nicotera; Biochem Biophys Res Commun. 2010 Mar 15. [Epub ahead of print]
Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
MT Heneka, F Nadrigny, T Regen, A Martinez-Hernandez, L Dumitrescu-Ozimek, D Terwel, D Jardanhazi-Kurutz, J Walter, F Kirchhoff, UK Hanisch, MP Kummer; Proc Natl Acad Sci USA. 2010 Mar 15.
Home care counseling for recipients of cash payments in the German long-term care insurance. [Article in German]
A Büscher, B Holle, S Emmert, A Fringer; Z Gerontol Geriatr. 2010 Mar 11. [Epub ahead of print]
Prevalence of Malnutrition, Interventions and Quality Indicators in German Nursing Homes - First Results of a Nationwide Pilot Study.
S Bartholomeyczik, S Reuther, L Luft, N van Nie, J Meijers, J Schols, R Halfens; Gesundheitswesen. 2010 Mar 10. [Epub ahead of print]
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease.
C Plant, SJ Teipel, A Oswald, C Bohm, T Meindl, J Mourao-Miranda, et al.; Neuroimage 2010 Mar; 50(1): 162-74. Epub 2009 Dec 2.
Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons
K Young, L Pinon, E Bampton and P Nicotera; Journal of Biochemical and Molecular Toxicology, March 2010
Nuclear pore complex during neuronal degeneration: Cracking the last barrier!
D Bano, MO Hengartner, P Nicotera; Nucleus; 2010 March/April.
Brain oscillations and memory.
E Düzel, WD Penny, N Burgess.; Curr Opin Neurobiol. 2010 Feb 22. [Epub ahead of print]
Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo.
Paquet D, Schmid B, Haass C.; Neurodegener Dis. 2010 Feb 18; 7(1-3):99-102. [Epub ahead of print]
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.
D. Edbauer, JR Neilson, KA Foster, CF Wang, DP Seeburg, MN Batterton, T. Tada, BM Dolan, PA Sharp, M. Sheng, Neuron. 2010 Feb 11;65(3):373-84.
Masking of transmembrane-based retention signals controls ER export of gamma-secretase.
M Fassler, M Zocher, S Klare, AG de la Fuente, J Scheuermann, A Capell, C Haass, C Valkova, A Veerappan, D Schneider, C Kaether; Traffic. 2010 Feb;11(2):250-8. Epub 2009 Nov 5.
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage
BI Perez-Revuelta, A Fukumori, S Lammich, A Yamasaki, C Haass, H Steiner; J Neurochem. 2010 Feb 10; 112(4):940-50
Knowledge transfer for the management of dementia: a cluster-randomised trial of blended learning in general practice
HC Vollmar, H Mayer, T Ostermann, ME Butzlaff, JE Sandars, S Wilm, MA Rieger; Implementation Science, 2010, 5:1
Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration
S Bartesaghi, J Betts-Henderson, K Cain, D Dinsdale, X Zhou, A Karlsson, P Salomoni and P Nicotera; Human Molecular Genetics, February 2010
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps
L Schebelle, C Wolf, C Stribl,T Javaheri, F Schnutgen, A Ettinger, Z Ivics, J Hansen, P Ruiz, H von Melchner, W Wurst, T Floss; Nucl. Acids Res. 2010 Febr 5
Early neuronal dysfunction by amyloid [beta] oligomers depends on activation of NR2B-containing NMDA receptors
R Roenicke, M Mikhaylova, S Roenicke, J Meinhardt, UH Schroeder, M. Faendrich, G Reiser, MR Kreutz, KG Reymann; Neurobiol Aging 2010 Feb 2
White matter microstructure underlying default mode network connectivity in the human brain
SJ Teipel, AL Bokde, T Meindl, E Amaro Jr, J Soldner, MF Reiser, SC Herpertz, HJ Moeller, H Hampel; Neuroimage 2010 Feb 1; 49(3): 2021-32. Epub 2009 Oct 28.
[Summer school of the European Academy of Nursing Science: encounter is the primary aim].
I Gnass, JG Schlarmann, A Haut, E Sirsch; Pflege Z. 2010 Feb;63(2):114-5.
Development and implementation of the dementia guideline of the German Society of General Practice and Family Medicine
HC Vollmar, HH Abholz, G Egidi, P Mand, ME Butzlaff, S Wilm; Med Klin (Munich). 2010 Jan; 105(1):41-7.
Sporadic ataxia with adult onset: classification and diagnostic criteria.
T Klockgether; Lancet Neurol. 2010 Jan; 9(1): 94-104.
Emotional and cognitive aspects of empathy and their relation to social cognition-an fMRI-study.
UM Krämer, B Mohammadi, N Donamayor, A Samii, TF Münte; Brain Res. 2010 Jan 22.
Paraquat and Parkinson's disease
C Berry, C La Vecchia, P Nicotera; Cell Death Differ. 2010 Jan 22
Alteration of the nuclear pore complex in Ca2+-mediated cell death
D Bano, D Dinsdale, A Cabrera-Socorro, S Maida, N Lambacher, B Mccoll E Ferrando-May, MO Hengartner and P Nicotera; Cell Death Differ 2010 Jan; 17(1): 119-133.
The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development
J Betts-Henderson, S Bartesaghi, M Crosier, S Lindsay, HL Chen, P Salomoni, I Gottlob and P Nicotera; Hum. Mol. Genet. 2010 Jan 15; 19(2): 342-351
Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging
KL Bergfield, KD Hanson, K Chen, SJ Teipel, H Hampel, SI Rapoport, JR Moeller, GE Alexander; Neuroimage 2010 Jan 15; 49(2): 1750-9. Epub 2009 Sep 28.
Basal forebrain integrity and cognitive memory profile in healthy aging.
S Düzel, TF Münte, U Lindenberger, N Bunzeck, H Schütze, HJ Heinze, E Düzel; Brain Res. 2010 Jan 13;1308:124-36. Epub 2009 Oct 23.
Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease.
W Maetzler, V Stoycheva, B Schmid, C Schulte, AK Hauser, K Brockmann, A Melms, T Gasser, D Berg; J Alzheimers Dis. 2010 Jan 1;22(3):933-8.
Cell Death and Disease: a new journal for a central area of pathophysiology.
G. Kroemer, P. Nicotera, G. Melino, Cell Death Dis. 2010 Jan;1(1):e11.
Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect
S Stuebner, T Faus-Kessler, T Fischer, W Wurst, N Prakash; Dev Dyn 2010 Jan; 239(1):246-60
Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.
G. Castelo-Branco, ER Andersson, E. Minina, KM Sousa, D. Ribeiro, C. Kokubu, K. Imai, N. Prakash, W. Wurst, E. Arenas, Dev Dyn. 2010 Jan;239(1):211-21.
Demenzielle Erkrankungen.
Vollmar HC, Der Hausarzt. 2010, 17 (10): 34-36.
Gesundheitsinformationen im Internet: Chancen für Patienten und Ärzte.
Schürer-Maly CC, Vollmar HC, Deutsches Ärzteblatt, Suppl. Praxis, 2010, 107 (15): 6-7
Editorial: Innovationen im Gesundheitswesen.
Vollmar HC, Zeitschrift für Evidenz, Fortbildung und Qualität 2010; 104 (10: 699-700)
Quo Vadis Dementia? Similarities and differences between specialist and family medicine guidelines [Quo vadis Demenz? Inhaltliche gemeinsamkeiten und unterschiede zwischen der spezialistischen und der hausärztlichen leitlinie]
HC Vollmar, H-H Abholz, G Egidi, S Wilms; Zeitschrift fur Allgemeinmedizin, 2010.
Mitochondrial dysfunction in Parkinson's disease
KF Winklhofer, C Haass; Biochim Biophys Acta. 2010; 1802(1):29-44.
Transcranial sonography for the discrimination of idiopathic Parkinson's disease from the atypical Parkinsonian syndromes.
AEP Bouwmans, AMM Vlaar, K Srulijes, WH Mess, WEJ Weber; Int Rev Neurobiol. 2010.
Umgang mit herausforderndem Verhalten in der professionellen Pflege. IdA als Instrument zu Klärung der Gründe.
M Halek, S Bartholomeyczik; Psychotherapie im Alter, 7(4), 507-520. 2010.
Transcranial sonography in essential tremor.
H Stockner, I Wurster; Int Rev Neurobiol. 2010
Transcranial sonography in dystonia.
A Gaenslen; Int Rev Neurobiol. 2010
Transcranial sonography in restless legs syndrome.
J Godau, M Sojer; Int Rev Neurobiol. 2010
Identifying PD-causing genes and genetic susceptibility factors: Current approaches and future prospects.
T Gasser; Prog Brain Res. 2010
Transcranial sonography in movement disorders. Conclusions.
D Berg; Int Rev Neurobiol. 2010;90:287-9.
TCS in monogenic forms of Parkinson's disease
K Brockmann, J Hagenah; Int Rev Neurobiol. 2010.
Assessment of innovations in clinical research: strengths and potentials for improvement of research in Germany.
HC Vollmar, P Georgieff, B Bührlen; Z Evid Fortbild Qual Gesundhwes. 2010
Patienteninformationen und Kreuzschmerzen (PIK-Studie) – Einfluss von Patienteninformationen auf Wissen und Funktionskapazität von Patienten mit akuten, unkomplizierten Rückenschmerzen.
B Bücker, M Butzlaff, J Isfort, N Koneczny, HC Vollmar, S Lange, G Lutz, MA Rieger, Das Gesundheitswesen 2010; 72:. e78-e88.
Transcranial sonography-anatomy
H Huber; Int Rev Neurobiol. 2010.
Early diagnosis of Parkinson's disease.
A Gaenslen, D Berg; Int Rev Neurobiol. 2010.
Transcranial sonography in the premotor diagnosis of Parkinson's disease.
S Behnke, U Schröder, D Berg; Int Rev Neurobiol. 2010
Longitudinal changes in fiber tract integrity in healthy aging and mild cognitive impairment: a DTI follow-up study.
SJ Teipel, T Meindl, M Wagner, B Stieltjes, S Reuter, KH Hauenstein, M Filippi, U Ernemann, MF Reiser, H Hampel; J alzheimers Dis. 2010; 22(2): 507-22.
Diagnostic utility of novel MRI-based biomarkers for Alzheimer's disease: diffusion tensor imaging and deformation-based morphometry.
U Friese, T Meindl, SC Herpertz, MF Reiser, H Hampel, SJ Teipel; J Alzheimers Dis. 2010; 20(2):477-90.
Nutzen des DatScan bei möglicher Lewy-Body-Demenz.
DM Bittner, NG Müller, V Bittner; Klin Neurophysiol 2010.
The prion protein: friend and foe.
J Tatzelt; Curr Issues Mol Biol. 2010; 12(2): 49. Epub 2009 Sep 18.
INTERSNP: genome-wide interaction analysis guided by a priori information.
C Herold, M Steffens, FF Brockschmidt, MP Baur, T Becker; Bioinformatics. 2009 Dec 15.
Hippocampus-dependent and -independent theta-networks of active maintenance.
N Cashdollar, U Malecki, FJ Rugg-Gunn, JS Duncan, N Lavie, E Duzel; Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20493-8. Epub 2009 Nov 16.
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
J Simón-Sánchez, C Schulte, JM Bras, M Sharma, JR Gibbs, D Berg, C Paisan-Ruiz, P Lichtner, SW Scholz, DG Hernandez, R Krüger, M Federoff, C Klein, A Goate, J Perlmutter, M Bonin, MA Nalls, T Illig, C Gieger, H Houlden, M Steffens, MS Okun, BA Racette, MR Cookson, KD Foote, HH Fernandez, BJ Traynor, S Schreiber, S Arepalli, R Zonozi, K Gwinn, M van der Brug, G Lopez, SJ Chanock, A Schatzkin, Y Park, A Hollenbeck, J Gao, X Huang, NW Wood, D Lorenz, G Deuschl, H Chen, O Riess, JA Hardy, AB Singleton, T Gasser; Nat Genet. 2009 Dec; 41(12): 1308-12. Epub 2009 Nov 15.
Extracellular Engrailed Participates in the Topographic Guidance of Retinal Axons in Vivo.
A Wizenmann, I Brunet, JSY lam, L Sonnier, M Beurdeley, K Zarbalis, D Weisenhorn-Vogt, C Weinl, A Dwivedy, A joliot, W Wurst, C Holt, A Prochiantz; Neuron. 2009 Nov 12.
Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary.
DM Wittmann, F Blöchl, D Trümbach, W Wurst, N Prakash, FJ Theis; PLoS Comput Biol. 2009 Nov; 5(11): e1000569. Epub 2009 Nov 20.
Formation and maintenance of Alzheimer’s disease β-amyloid plaques in the absence of microglia
SA Grathwohl, RE Kälin, T Bolmont, S Prokop, G Winkelmann, SA Kaeser, J Odenthal, R Radde, T Eldh, S Gandy, A Aguzzi, M Staufenbiel, PM Mathews, H Wolburg, FL Heppner, M Jucker; Nat Neurosci. 2009 Nov; 12(11): 1361-3. Epub 2009 Oct 18.
A reporter of local dendritic translocation shows plaque-related loss of neural system function in APP-transgenic mice.
M Meyer-Luehmann, M Mielke, TL Spires-Jones, W Stoothoff, P Jones, BJ Bacskai, BT Hyman; J Neurosci. 2009 Oct 7.
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
N Itoh, M Okochi, S Tagami, K Nishitomi, T Nakayama, K Yanagida, A Fukumori, J Jiang, K Mori, M Hosono, J Kikuchi, Y Nakano, Y Takinami, K Dohi, A Nishigaki, H Takemoto, K Minagawa, T Katoh, M Willem, C Haass, T Morihara, T Tanaka, T Kudo, H Hasegawa, M Nishimura, G Sakaguchi, A Kato, Takeda ; Neurodegener Dis. 2009 Sep 9
Alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum.
M Miesbauer, NV Pfeiffer, AS Rambold, V Müller, S Kiachopoulos, KF Winklhofer, J Tatzelt; J Biol Chem. 2009 Sep 4; 284(36): 24384-93. Epub 2009 Jun 26.
Targeting of the Prion Protein to the Cytosol: Mechanisms and Consequences.
M Miesbauer, AS Rambold, KF Winklhofer, J Tatzelt; Curr Issues Mol Biol. 2009 Sep 18;12(2): 109-118. [Epub ahead of print]
Reward Motivation Accelerates the Onset of Neural Novelty Signals in Humans to 85 Milliseconds.
N Bunzeck, CF Doeller, L Fuentemilla, RJ Dolan, E Duzel; Curr Biol. 2009 Aug 11.
Induction of cerebral beta-amyloidosis: Intracerebral versus systemic Abeta inoculation.
Y. S. Eisele, T Bolmont, M Heikenwalder, F Langer, L. H. Jacobson, Z.-X. Yan, K Roth, A Aguzzi, M Staufenbiel, L. C. Walker, M Jucker; Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12926-31. Epub 2009 Jul 21.
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.
Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF; J Biol Chem. 2009 Aug 21; 284(34): 22938-51. Epub 2009 Jun 22.
Gamma-Secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway
T Bittner, M Fuhrmann, S Burgold, CK Jung, C Volbracht, H Steiner, G Mitteregger, HA Kretzschmar, C Haass, J Herms; J Neurosci. 2009 Aug 19;29(33):10405-9
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain
N Prakash. E Puelles, K Freude, D Truembach, D Omodei, M Di Salvio, LSussel, J Ericson, M Sander, A Simeone, W. Wurst; Development. 2009 Aug;136(15);2545-55
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
D Dormann, A Capell, AM Carlson, SS Shankaran, R Rodde, M Neumann, E Kremmer, T Matsuwaki, K Yamanouchi, M Nishihara, C Haass C; J Neurochem. 2009 Aug; 110(3):1082-94. Epub 2009 Jun 9.
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.
R Fluhrer, H Steiner, C Haass; J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation.
D Paquet, R Bhat, A Sydow, EM Mandelkow, S Berg, S Hellberg, J Fälting, M Distel, RW Köster, B Schmid, C Haass; J Clin Invest. 2009 May; 119(5): 1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.
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