Publications

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid Beta formation.

Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, Haass C, Reichert AS, Müller WE. Antioxid Redox Signal. 2012 Jun 15;16(12):1421-33. Epub 2012 Feb 28.

Publications

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid Beta formation.

Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State.

The nuclear form of Glutathione Peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization.

Generation of a novel rodent model for DYT1 dystonia.

Response to Brosch et al.

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.

Cellular prion protein mediates toxic signaling of amyloid Beta.

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.

Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation.

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.

Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking.

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease.

The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b).

BACE1 Dependent Neuregulin Processing: Review.

Lack of Pur-alpha alters postnatal brain development and causes megalencephaly.

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.

Cell biology. Sheddase gets guidance.

Role of APP for dendritic spine formation and stability.

ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signalling.

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.

Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.

Brain-Specific Inactivation of the Crhr1 Gene Inhibits Post-Dependent and Stress-Induced Alcohol Intake, but Does Not Affect Relapse-Like Drinking.

Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.

Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on Mammalian male fertilizing ability.

The Nicastrin ectodomain adopts a highly thermostable structure

Novel {gamma}-Secretase Enzyme Modulators Directly Target Presenilin Protein.

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

microRNA-34c is a novel target to treat dementias.

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages

Forebrain CRF1 modulates early-life stress-programmed cognitive deficits

Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons

miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity

Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

Biodistribution and brain permeability of the extracellular domain of neuregulin-1-β1

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

JNK plays a key role in tau hyperphosphorylation in alzheimer's disease models

N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant.

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

TDP-43 and FUS: a nuclear affair.

Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase.

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing.

Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice

Neuroprotective and Neurotoxic Signaling by the Prion Protein.

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease.

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.

Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays.

Constitutive and conditional RNAi transgenesis in mice.

Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation.

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons.

Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis.

Resources for proteomics in mouse embryonic stem cells.

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.

F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.

ADAM10: Potential 'molecular scissors for the treatment of Alzheimers disease.

Alpha-secretase in Alzheimer's disease: Molecular identity, regulation and therapeutic potential.

A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons.

Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.

Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus.

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.

Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models.

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.

Boxing-acute complications and late sequelae: from concussion to dementia.

Initiation and propagation of neurodegeneration.

Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including Amyloid beta Precursor Protein.

Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing.

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

12/15-Lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.

Fyn-tau-amyloid: a toxic triad.

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons.

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.

Phenotypic annotation of the mouse X chromosome.

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.